TNF-α in Uveitis: From Bench to Clinic
Uveitis is an inflammation of the iris, ciliary body, vitreous, retina, or choroid, which has been shown to be the first manifestation of numerous systemic diseases. Studies about the immunopathogenesis and treatment of uveitis are helpful to comprehend systemic autoimmune diseases, and delay the pr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.740057/full |
| _version_ | 1818987647232638976 |
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| author | Qi Jiang Zhaohuai Li Tianyu Tao Runping Duan Xianggui Wang Xianggui Wang Wenru Su |
| author_facet | Qi Jiang Zhaohuai Li Tianyu Tao Runping Duan Xianggui Wang Xianggui Wang Wenru Su |
| author_sort | Qi Jiang |
| collection | DOAJ |
| description | Uveitis is an inflammation of the iris, ciliary body, vitreous, retina, or choroid, which has been shown to be the first manifestation of numerous systemic diseases. Studies about the immunopathogenesis and treatment of uveitis are helpful to comprehend systemic autoimmune diseases, and delay the progression of systemic autoimmune diseases, respectively. Tumor necrosis factor-alpha (TNF-α), a pleiotropic cytokine, plays a pivotal role in intraocular inflammation based on experimental and clinical data. Evidence of the feasibility of using anti-TNF-α agents for uveitis management has increased. Although there are numerous studies on TNF-α in various autoimmune diseases, the pathological mechanism and research progress of TNF-α in uveitis have not been reviewed. Therefore, the objective of this review is to provide a background on the role of TNF-α in the immunopathogenesis of uveitis, as well as from bench to clinical research progress, to better guide TNF-α-based therapeutics for uveitis. |
| first_indexed | 2024-12-20T19:10:01Z |
| format | Article |
| id | doaj.art-fa7ce6b4ebc14197ba436b6bbde7492e |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-20T19:10:01Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-fa7ce6b4ebc14197ba436b6bbde7492e2022-12-21T19:29:14ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-11-011210.3389/fphar.2021.740057740057TNF-α in Uveitis: From Bench to ClinicQi Jiang0Zhaohuai Li1Tianyu Tao2Runping Duan3Xianggui Wang4Xianggui Wang5Wenru Su6State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaEye Center of Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Ophthalmology, Changsha, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaUveitis is an inflammation of the iris, ciliary body, vitreous, retina, or choroid, which has been shown to be the first manifestation of numerous systemic diseases. Studies about the immunopathogenesis and treatment of uveitis are helpful to comprehend systemic autoimmune diseases, and delay the progression of systemic autoimmune diseases, respectively. Tumor necrosis factor-alpha (TNF-α), a pleiotropic cytokine, plays a pivotal role in intraocular inflammation based on experimental and clinical data. Evidence of the feasibility of using anti-TNF-α agents for uveitis management has increased. Although there are numerous studies on TNF-α in various autoimmune diseases, the pathological mechanism and research progress of TNF-α in uveitis have not been reviewed. Therefore, the objective of this review is to provide a background on the role of TNF-α in the immunopathogenesis of uveitis, as well as from bench to clinical research progress, to better guide TNF-α-based therapeutics for uveitis.https://www.frontiersin.org/articles/10.3389/fphar.2021.740057/fulluveitisTNF-αanti-TNF-α agentsinfliximabadalimumabgolimumab |
| spellingShingle | Qi Jiang Zhaohuai Li Tianyu Tao Runping Duan Xianggui Wang Xianggui Wang Wenru Su TNF-α in Uveitis: From Bench to Clinic Frontiers in Pharmacology uveitis TNF-α anti-TNF-α agents infliximab adalimumab golimumab |
| title | TNF-α in Uveitis: From Bench to Clinic |
| title_full | TNF-α in Uveitis: From Bench to Clinic |
| title_fullStr | TNF-α in Uveitis: From Bench to Clinic |
| title_full_unstemmed | TNF-α in Uveitis: From Bench to Clinic |
| title_short | TNF-α in Uveitis: From Bench to Clinic |
| title_sort | tnf α in uveitis from bench to clinic |
| topic | uveitis TNF-α anti-TNF-α agents infliximab adalimumab golimumab |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.740057/full |
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