A Feasibility Study of an Extrusion-Based Fabrication Process for Personalized Drugs
Developing a high-efficiency manufacturing system for personalized medicine plays an important role in increasing the feasibility of personalized medication. The purpose of this study is to investigate the feasibility of a new extrusion-based fabrication process for personalized drugs with a faster...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/10/1/16 |
| _version_ | 1797758676611629056 |
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| author | Ilhan Yu Roland K. Chen |
| author_facet | Ilhan Yu Roland K. Chen |
| author_sort | Ilhan Yu |
| collection | DOAJ |
| description | Developing a high-efficiency manufacturing system for personalized medicine plays an important role in increasing the feasibility of personalized medication. The purpose of this study is to investigate the feasibility of a new extrusion-based fabrication process for personalized drugs with a faster production rate. This process uses two syringe pumps with a coaxial needle as an extruder, which extrudes two materials with varying ratios into a capsule. The mixture of hydrogel, polyethylene glycol (PEG), hydroxypropyl methylcellulose, poly acrylic acid and the simulated active pharmaceutical ingredient, Aspirin, was used. To validate the method, samples with different ratios of immediate release (IR) and sustained release (SR) mixtures were fabricated. The results of a dissolution test show that it is feasible to control the release profile by changing the IR and SR ratio using this fabrication setup. The fabrication time for each capsule is about 20 seconds, which is significantly faster than the current 3D printing methods. In conclusion, the proposed fabrication method shows a clear potential to step toward the feasibility of personalized medication. |
| first_indexed | 2024-03-12T18:33:29Z |
| format | Article |
| id | doaj.art-fa7d622f4c4043178674de4f22fe997e |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-12T18:33:29Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-fa7d622f4c4043178674de4f22fe997e2023-08-02T08:12:35ZengMDPI AGJournal of Personalized Medicine2075-44262020-03-011011610.3390/jpm10010016jpm10010016A Feasibility Study of an Extrusion-Based Fabrication Process for Personalized DrugsIlhan Yu0Roland K. Chen1School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USASchool of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USADeveloping a high-efficiency manufacturing system for personalized medicine plays an important role in increasing the feasibility of personalized medication. The purpose of this study is to investigate the feasibility of a new extrusion-based fabrication process for personalized drugs with a faster production rate. This process uses two syringe pumps with a coaxial needle as an extruder, which extrudes two materials with varying ratios into a capsule. The mixture of hydrogel, polyethylene glycol (PEG), hydroxypropyl methylcellulose, poly acrylic acid and the simulated active pharmaceutical ingredient, Aspirin, was used. To validate the method, samples with different ratios of immediate release (IR) and sustained release (SR) mixtures were fabricated. The results of a dissolution test show that it is feasible to control the release profile by changing the IR and SR ratio using this fabrication setup. The fabrication time for each capsule is about 20 seconds, which is significantly faster than the current 3D printing methods. In conclusion, the proposed fabrication method shows a clear potential to step toward the feasibility of personalized medication.https://www.mdpi.com/2075-4426/10/1/16personalized medicinemanufacturingdrug deliverycontrolled release3d printing |
| spellingShingle | Ilhan Yu Roland K. Chen A Feasibility Study of an Extrusion-Based Fabrication Process for Personalized Drugs Journal of Personalized Medicine personalized medicine manufacturing drug delivery controlled release 3d printing |
| title | A Feasibility Study of an Extrusion-Based Fabrication Process for Personalized Drugs |
| title_full | A Feasibility Study of an Extrusion-Based Fabrication Process for Personalized Drugs |
| title_fullStr | A Feasibility Study of an Extrusion-Based Fabrication Process for Personalized Drugs |
| title_full_unstemmed | A Feasibility Study of an Extrusion-Based Fabrication Process for Personalized Drugs |
| title_short | A Feasibility Study of an Extrusion-Based Fabrication Process for Personalized Drugs |
| title_sort | feasibility study of an extrusion based fabrication process for personalized drugs |
| topic | personalized medicine manufacturing drug delivery controlled release 3d printing |
| url | https://www.mdpi.com/2075-4426/10/1/16 |
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