Advances of exosomes in periodontitis treatment
Abstract Periodontitis is an inflammatory disease initiated by dysbiosis of the local microbial community. Periodontitis can result in destruction of tooth-supporting tissue; however, overactivation of the host immune response is the main reason for alveolar bone loss. Periodontal tissue cells, immu...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-022-03487-4 |
| _version_ | 1811235703869145088 |
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| author | Hongbing Lin Huishan Chen Xuetao Zhao Tong Ding Yawei Wang Zhen Chen Yue Tian Peipei Zhang Yuqin Shen |
| author_facet | Hongbing Lin Huishan Chen Xuetao Zhao Tong Ding Yawei Wang Zhen Chen Yue Tian Peipei Zhang Yuqin Shen |
| author_sort | Hongbing Lin |
| collection | DOAJ |
| description | Abstract Periodontitis is an inflammatory disease initiated by dysbiosis of the local microbial community. Periodontitis can result in destruction of tooth-supporting tissue; however, overactivation of the host immune response is the main reason for alveolar bone loss. Periodontal tissue cells, immune cells, and even further activated osteoclasts and neutrophils play pro-inflammatory or anti-inflammatory roles. Traditional therapies for periodontitis are effective in reducing the microbial quantities and improving the clinical symptoms of periodontitis. However, these methods are non-selective, and it is still challenging to achieve an ideal treatment effect in clinics using the currently available treatments and approaches. Exosomes have shown promising potential in various preclinical and clinical studies, including in the diagnosis and treatment of periodontitis. Exos can be secreted by almost all types of cells, containing specific substances of cells: RNA, free fatty acids, proteins, surface receptors and cytokines. Exos act as local and systemic intercellular communication medium, play significant roles in various biological functions, and regulate physiological and pathological processes in numerous diseases. Exos-based periodontitis diagnosis and treatment strategies have been reported to obtain the potential to overcome the drawbacks of traditional therapies. This review focuses on the accumulating evidence from the last 5 years, indicating the therapeutic potential of the Exos in preclinical and clinical studies of periodontitis. Recent advances on Exos-based periodontitis diagnosis and treatment strategies, existing challenges, and prospect are summarized as guidance to improve the effectiveness of Exos on periodontitis in clinics. |
| first_indexed | 2024-04-12T11:56:31Z |
| format | Article |
| id | doaj.art-fa7f5457959544a2bd8ddc3db2ccedc7 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-12T11:56:31Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-fa7f5457959544a2bd8ddc3db2ccedc72022-12-22T03:34:00ZengBMCJournal of Translational Medicine1479-58762022-06-0120111110.1186/s12967-022-03487-4Advances of exosomes in periodontitis treatmentHongbing Lin0Huishan Chen1Xuetao Zhao2Tong Ding3Yawei Wang4Zhen Chen5Yue Tian6Peipei Zhang7Yuqin Shen8Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin UniversityJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin UniversityJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin UniversityJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin UniversityJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin UniversityDepartment of Periodontics, Affiliated Stomatology Hospital of Guangzhou Medical University,, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative MedicineJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin UniversityJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin UniversityJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin UniversityAbstract Periodontitis is an inflammatory disease initiated by dysbiosis of the local microbial community. Periodontitis can result in destruction of tooth-supporting tissue; however, overactivation of the host immune response is the main reason for alveolar bone loss. Periodontal tissue cells, immune cells, and even further activated osteoclasts and neutrophils play pro-inflammatory or anti-inflammatory roles. Traditional therapies for periodontitis are effective in reducing the microbial quantities and improving the clinical symptoms of periodontitis. However, these methods are non-selective, and it is still challenging to achieve an ideal treatment effect in clinics using the currently available treatments and approaches. Exosomes have shown promising potential in various preclinical and clinical studies, including in the diagnosis and treatment of periodontitis. Exos can be secreted by almost all types of cells, containing specific substances of cells: RNA, free fatty acids, proteins, surface receptors and cytokines. Exos act as local and systemic intercellular communication medium, play significant roles in various biological functions, and regulate physiological and pathological processes in numerous diseases. Exos-based periodontitis diagnosis and treatment strategies have been reported to obtain the potential to overcome the drawbacks of traditional therapies. This review focuses on the accumulating evidence from the last 5 years, indicating the therapeutic potential of the Exos in preclinical and clinical studies of periodontitis. Recent advances on Exos-based periodontitis diagnosis and treatment strategies, existing challenges, and prospect are summarized as guidance to improve the effectiveness of Exos on periodontitis in clinics.https://doi.org/10.1186/s12967-022-03487-4PeriodontitisExosomesImmunomodulationImmune cellsOsteoclast |
| spellingShingle | Hongbing Lin Huishan Chen Xuetao Zhao Tong Ding Yawei Wang Zhen Chen Yue Tian Peipei Zhang Yuqin Shen Advances of exosomes in periodontitis treatment Journal of Translational Medicine Periodontitis Exosomes Immunomodulation Immune cells Osteoclast |
| title | Advances of exosomes in periodontitis treatment |
| title_full | Advances of exosomes in periodontitis treatment |
| title_fullStr | Advances of exosomes in periodontitis treatment |
| title_full_unstemmed | Advances of exosomes in periodontitis treatment |
| title_short | Advances of exosomes in periodontitis treatment |
| title_sort | advances of exosomes in periodontitis treatment |
| topic | Periodontitis Exosomes Immunomodulation Immune cells Osteoclast |
| url | https://doi.org/10.1186/s12967-022-03487-4 |
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