Age-Dependent Activation of Purinergic Transmission Contributes to the Development of Epileptogenesis in ADSHE Model Rats

Age-Dependent Activation of Purinergic Transmission Contributes to the Development of Epileptogenesis in ADSHE Model Rats

To explore the developmental processes of epileptogenesis/ictogenesis, this study determined age-dependent functional abnormalities associated with purinergic transmission in a genetic rat model (S286L-TG) of autosomal-dominant sleep-related hypermotor epilepsy (ADSHE). The age-dependent fluctuation...

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Bibliographic Details
Main Authors: Kouji Fukuyama, Eishi Motomura, Motohiro Okada
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Biomolecules
Subjects:
ADSHE
astrocytes
ATP
epileptogenesis
P2X7 receptor
Online Access:https://www.mdpi.com/2218-273X/14/2/204

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