Focal liver lesions: interobserver and intraobserver agreement of three-dimensional contrast-enhanced ultrasound-assisted volume measurements
Purpose This study was conducted to assess the interobserver and intraobserver agreement of three-dimensional contrast-enhanced ultrasound (3D-CEUS) volume calculations of focal liver lesions (FLLs). Methods Thirty-nine patients (15 men and 24 women; mean age, 55.4 years) with 39 FLLs (mean size, 3....
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Ultrasound in Medicine
2021-07-01
|
| Series: | Ultrasonography |
| Subjects: | |
| Online Access: | http://www.e-ultrasonography.org/upload/usg-20025.pdf |
| _version_ | 1818609697673969664 |
|---|---|
| author | Tommaso Vincenzo Bartolotta Antonio Sidoti Pinto Roberto Cannella Giorgia Porrello Rossana Taravella Angelo Randazzo Adele Taibbi |
| author_facet | Tommaso Vincenzo Bartolotta Antonio Sidoti Pinto Roberto Cannella Giorgia Porrello Rossana Taravella Angelo Randazzo Adele Taibbi |
| author_sort | Tommaso Vincenzo Bartolotta |
| collection | DOAJ |
| description | Purpose This study was conducted to assess the interobserver and intraobserver agreement of three-dimensional contrast-enhanced ultrasound (3D-CEUS) volume calculations of focal liver lesions (FLLs). Methods Thirty-nine patients (15 men and 24 women; mean age, 55.4 years) with 39 FLLs (mean size, 3.1±1.8 cm; size range, 1 to 8 cm) prospectively underwent 3D-CEUS. Four readers calculated the volume of each lesion in an independent and blinded fashion in two separate sessions by means of a semi-automatic, commercially available proprietary software. The differences in lesion volumes (cm3) among sessions and readers were assessed using the Mann-Whitney U test and the Kruskal-Wallis test. Bland-Altman analysis was also performed. Intraclass correlation coefficients (ICCs) with 95% confidence intervals (95% CIs) were calculated. The statistical significance level was set at P<0.05. Results Among readers, there were no statistically significant differences in the first (P=0.953) and second (P=0.592) reading sessions for volume calculations of the 39 FLLs, with almost perfect inter-reader agreement (ICC values of the first reading session, 0.996; 95% CI, 0.992 to 0.998 and ICC value of the second reading session, 0.994; 95% CI, 0.990 to 0.997, respectively). For each of the four readers, there were no significant differences in volume calculations between the two sessions (P=0.503-0.924), and the intrareader agreement was almost perfect for each reader (R1: ICC, 0.995; 95% CI, 0.991 to 0.998; R2: ICC, 0.995; 95% CI, 0.988 to 0.997; R3: ICC, 0.996; 95% CI, 0.992 to 0.998; R4: ICC, 0.985; 95% CI, 0.971 to 0.992). Conclusion 3D-CEUS volume calculations provided consistent measurements across different readers with almost perfect intrareader agreement. |
| first_indexed | 2024-12-16T15:02:40Z |
| format | Article |
| id | doaj.art-fa814d3cb2f94a0bb5f9c9289b581b8d |
| institution | Directory Open Access Journal |
| issn | 2288-5919 2288-5943 |
| language | English |
| last_indexed | 2024-12-16T15:02:40Z |
| publishDate | 2021-07-01 |
| publisher | Korean Society of Ultrasound in Medicine |
| record_format | Article |
| series | Ultrasonography |
| spelling | doaj.art-fa814d3cb2f94a0bb5f9c9289b581b8d2022-12-21T22:27:14ZengKorean Society of Ultrasound in MedicineUltrasonography2288-59192288-59432021-07-0140333334110.14366/usg.200251134Focal liver lesions: interobserver and intraobserver agreement of three-dimensional contrast-enhanced ultrasound-assisted volume measurementsTommaso Vincenzo Bartolotta0Antonio Sidoti Pinto1Roberto Cannella2Giorgia Porrello3Rossana Taravella4Angelo Randazzo5Adele Taibbi6 Section of Radiology - BiND, University Hospital "Paolo Giaccone", Palermo, Italy Section of Radiology - BiND, University Hospital "Paolo Giaccone", Palermo, Italy Section of Radiology - BiND, University Hospital "Paolo Giaccone", Palermo, Italy Section of Radiology - BiND, University Hospital "Paolo Giaccone", Palermo, Italy Section of Radiology - BiND, University Hospital "Paolo Giaccone", Palermo, Italy Section of Radiology - BiND, University Hospital "Paolo Giaccone", Palermo, Italy Section of Radiology - BiND, University Hospital "Paolo Giaccone", Palermo, ItalyPurpose This study was conducted to assess the interobserver and intraobserver agreement of three-dimensional contrast-enhanced ultrasound (3D-CEUS) volume calculations of focal liver lesions (FLLs). Methods Thirty-nine patients (15 men and 24 women; mean age, 55.4 years) with 39 FLLs (mean size, 3.1±1.8 cm; size range, 1 to 8 cm) prospectively underwent 3D-CEUS. Four readers calculated the volume of each lesion in an independent and blinded fashion in two separate sessions by means of a semi-automatic, commercially available proprietary software. The differences in lesion volumes (cm3) among sessions and readers were assessed using the Mann-Whitney U test and the Kruskal-Wallis test. Bland-Altman analysis was also performed. Intraclass correlation coefficients (ICCs) with 95% confidence intervals (95% CIs) were calculated. The statistical significance level was set at P<0.05. Results Among readers, there were no statistically significant differences in the first (P=0.953) and second (P=0.592) reading sessions for volume calculations of the 39 FLLs, with almost perfect inter-reader agreement (ICC values of the first reading session, 0.996; 95% CI, 0.992 to 0.998 and ICC value of the second reading session, 0.994; 95% CI, 0.990 to 0.997, respectively). For each of the four readers, there were no significant differences in volume calculations between the two sessions (P=0.503-0.924), and the intrareader agreement was almost perfect for each reader (R1: ICC, 0.995; 95% CI, 0.991 to 0.998; R2: ICC, 0.995; 95% CI, 0.988 to 0.997; R3: ICC, 0.996; 95% CI, 0.992 to 0.998; R4: ICC, 0.985; 95% CI, 0.971 to 0.992). Conclusion 3D-CEUS volume calculations provided consistent measurements across different readers with almost perfect intrareader agreement.http://www.e-ultrasonography.org/upload/usg-20025.pdf3d ultrasoundliver diseasescontrast-enhanced ultrasonographytumor volume |
| spellingShingle | Tommaso Vincenzo Bartolotta Antonio Sidoti Pinto Roberto Cannella Giorgia Porrello Rossana Taravella Angelo Randazzo Adele Taibbi Focal liver lesions: interobserver and intraobserver agreement of three-dimensional contrast-enhanced ultrasound-assisted volume measurements Ultrasonography 3d ultrasound liver diseases contrast-enhanced ultrasonography tumor volume |
| title | Focal liver lesions: interobserver and intraobserver agreement of three-dimensional contrast-enhanced ultrasound-assisted volume measurements |
| title_full | Focal liver lesions: interobserver and intraobserver agreement of three-dimensional contrast-enhanced ultrasound-assisted volume measurements |
| title_fullStr | Focal liver lesions: interobserver and intraobserver agreement of three-dimensional contrast-enhanced ultrasound-assisted volume measurements |
| title_full_unstemmed | Focal liver lesions: interobserver and intraobserver agreement of three-dimensional contrast-enhanced ultrasound-assisted volume measurements |
| title_short | Focal liver lesions: interobserver and intraobserver agreement of three-dimensional contrast-enhanced ultrasound-assisted volume measurements |
| title_sort | focal liver lesions interobserver and intraobserver agreement of three dimensional contrast enhanced ultrasound assisted volume measurements |
| topic | 3d ultrasound liver diseases contrast-enhanced ultrasonography tumor volume |
| url | http://www.e-ultrasonography.org/upload/usg-20025.pdf |
| work_keys_str_mv | AT tommasovincenzobartolotta focalliverlesionsinterobserverandintraobserveragreementofthreedimensionalcontrastenhancedultrasoundassistedvolumemeasurements AT antoniosidotipinto focalliverlesionsinterobserverandintraobserveragreementofthreedimensionalcontrastenhancedultrasoundassistedvolumemeasurements AT robertocannella focalliverlesionsinterobserverandintraobserveragreementofthreedimensionalcontrastenhancedultrasoundassistedvolumemeasurements AT giorgiaporrello focalliverlesionsinterobserverandintraobserveragreementofthreedimensionalcontrastenhancedultrasoundassistedvolumemeasurements AT rossanataravella focalliverlesionsinterobserverandintraobserveragreementofthreedimensionalcontrastenhancedultrasoundassistedvolumemeasurements AT angelorandazzo focalliverlesionsinterobserverandintraobserveragreementofthreedimensionalcontrastenhancedultrasoundassistedvolumemeasurements AT adeletaibbi focalliverlesionsinterobserverandintraobserveragreementofthreedimensionalcontrastenhancedultrasoundassistedvolumemeasurements |