Evaluation of analogs of mutacin 1140 in systemic and cutaneous methicillin-resistant Staphylococcus aureus infection models in mice

Evaluation of analogs of mutacin 1140 in systemic and cutaneous methicillin-resistant Staphylococcus aureus infection models in mice

Mutacin 1140 (Mu1140) is a potent antibiotic against Gram-positive bacteria, such as Staphylococcus aureus. The antibiotic is produced by the oral bacterium Streptococcus mutans and is a member of the epidermin family of type AI lantibiotics. The antibiotic exerts its inhibitory activity by binding...

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Bibliographic Details
Main Authors: Min Ju, Thushinari Joseph, Nopakorn Hansanant, Mengxin Geng, McKinley Williams, Andrew Cothrell, Andrew Riley Buhrow, Frank Austin, Leif Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Microbiology
Subjects:
methicillin-resistant Staphylococcus aureus, MRSA
antibacterial
mutacin 1140
efficacy
lantibiotics
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1067410/full

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