Discovery of New DNA Topoisomerase II Inhibitors using Structure Based Virtual Screening Method
DNA topoisomerases are proved therapeutic targets of anticancer and antibacterial drugs. Structures of topoisomerase–DNA and inhibitor ternary complexes have revealed the exact binding sites and mechanisms of topoisomerase poisons. There are two isoforms of Human Topoisomerase II; α and β. Both of t...
Main Authors: | Tugba Ertan-Bolelli, Kayhan Bolelli |
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Format: | Article |
Language: | English |
Published: |
Turkish Chemical Society
2019-05-01
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Series: | Journal of the Turkish Chemical Society, Section A: Chemistry |
Subjects: | |
Online Access: | http://dergipark.gov.tr/jotcsa/issue/42264/466457 |
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