Estimating tuberculosis drug resistance amplification rates in high-burden settings

Estimating tuberculosis drug resistance amplification rates in high-burden settings

Abstract Background Antimicrobial resistance develops following the accrual of mutations in the bacterial genome, and may variably impact organism fitness and hence, transmission risk. Classical representation of tuberculosis (TB) dynamics using a single or two strain (DS/MDR-TB) model typically doe...

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Bibliographic Details
Main Authors: Malancha Karmakar, Romain Ragonnet, David B. Ascher, James M. Trauer, Justin T. Denholm
Format: Article
Language:English
Published: BMC 2022-01-01
Series:BMC Infectious Diseases
Subjects:
Drug resistant tuberculosis
Epidemiological modelling
Fitness cost
Tuberculosis transmission dynamics
Resistance amplification
Online Access:https://doi.org/10.1186/s12879-022-07067-1

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