Dietary omega-3 deficiency from gestation increases spinal cord vulnerability to traumatic brain injury-induced damage.
Although traumatic brain injury (TBI) is often associated with gait deficits, the effects of TBI on spinal cord centers are poorly understood. We seek to determine the influence of TBI on the spinal cord and the potential of dietary omega-3 (n-3) fatty acids to counteract these effects. Male rodents...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3532480?pdf=render |
| _version_ | 1830487032171855872 |
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| author | Zhe Ying Cameron Feng Rahul Agrawal Yumei Zhuang Fernando Gomez-Pinilla |
| author_facet | Zhe Ying Cameron Feng Rahul Agrawal Yumei Zhuang Fernando Gomez-Pinilla |
| author_sort | Zhe Ying |
| collection | DOAJ |
| description | Although traumatic brain injury (TBI) is often associated with gait deficits, the effects of TBI on spinal cord centers are poorly understood. We seek to determine the influence of TBI on the spinal cord and the potential of dietary omega-3 (n-3) fatty acids to counteract these effects. Male rodents exposed to diets containing adequate or deficient levels of n-3 since gestation received a moderate fluid percussion injury when becoming 14 weeks old. TBI reduced levels of molecular systems important for synaptic plasticity (BDNF, TrkB, and CREB) and plasma membrane homeostasis (4-HNE, iPLA2, syntaxin-3) in the lumbar spinal cord. These effects of TBI were more dramatic in the animals exposed to the n-3 deficient diet. Results emphasize the comprehensive action of TBI across the neuroaxis, and the critical role of dietary n-3 as a means to build resistance against the effects of TBI. |
| first_indexed | 2024-12-21T18:53:32Z |
| format | Article |
| id | doaj.art-fa870368c0f746489bd51da44d4e3477 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T18:53:32Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-fa870368c0f746489bd51da44d4e34772022-12-21T18:53:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01712e5299810.1371/journal.pone.0052998Dietary omega-3 deficiency from gestation increases spinal cord vulnerability to traumatic brain injury-induced damage.Zhe YingCameron FengRahul AgrawalYumei ZhuangFernando Gomez-PinillaAlthough traumatic brain injury (TBI) is often associated with gait deficits, the effects of TBI on spinal cord centers are poorly understood. We seek to determine the influence of TBI on the spinal cord and the potential of dietary omega-3 (n-3) fatty acids to counteract these effects. Male rodents exposed to diets containing adequate or deficient levels of n-3 since gestation received a moderate fluid percussion injury when becoming 14 weeks old. TBI reduced levels of molecular systems important for synaptic plasticity (BDNF, TrkB, and CREB) and plasma membrane homeostasis (4-HNE, iPLA2, syntaxin-3) in the lumbar spinal cord. These effects of TBI were more dramatic in the animals exposed to the n-3 deficient diet. Results emphasize the comprehensive action of TBI across the neuroaxis, and the critical role of dietary n-3 as a means to build resistance against the effects of TBI.http://europepmc.org/articles/PMC3532480?pdf=render |
| spellingShingle | Zhe Ying Cameron Feng Rahul Agrawal Yumei Zhuang Fernando Gomez-Pinilla Dietary omega-3 deficiency from gestation increases spinal cord vulnerability to traumatic brain injury-induced damage. PLoS ONE |
| title | Dietary omega-3 deficiency from gestation increases spinal cord vulnerability to traumatic brain injury-induced damage. |
| title_full | Dietary omega-3 deficiency from gestation increases spinal cord vulnerability to traumatic brain injury-induced damage. |
| title_fullStr | Dietary omega-3 deficiency from gestation increases spinal cord vulnerability to traumatic brain injury-induced damage. |
| title_full_unstemmed | Dietary omega-3 deficiency from gestation increases spinal cord vulnerability to traumatic brain injury-induced damage. |
| title_short | Dietary omega-3 deficiency from gestation increases spinal cord vulnerability to traumatic brain injury-induced damage. |
| title_sort | dietary omega 3 deficiency from gestation increases spinal cord vulnerability to traumatic brain injury induced damage |
| url | http://europepmc.org/articles/PMC3532480?pdf=render |
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