Effect of intraoperative dexmedetomidine infusion during functional endoscopic sinus surgery: a prospective cohort study
Abstract Background Dexmedetomidine, an α2 agonist, has well-known anesthetic and analgesic-sparing effects. We designed this study to evaluate the effect of intraoperative dexmedetomidine infusion on intra operative blood loss and postoperative pain in functional endoscopic sinus surgery. Methods T...
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | Patient Safety in Surgery |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13037-020-00264-4 |
| _version_ | 1818214957704019968 |
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| author | Mohammad Reza Fazel Zeynab Sadat Ahmadi Hossein Akbari Fahimeh Abam |
| author_facet | Mohammad Reza Fazel Zeynab Sadat Ahmadi Hossein Akbari Fahimeh Abam |
| author_sort | Mohammad Reza Fazel |
| collection | DOAJ |
| description | Abstract Background Dexmedetomidine, an α2 agonist, has well-known anesthetic and analgesic-sparing effects. We designed this study to evaluate the effect of intraoperative dexmedetomidine infusion on intra operative blood loss and postoperative pain in functional endoscopic sinus surgery. Methods This prospective cohort study included 90 patients planning to undergo endoscopic sinus surgery, who were randomly divided into three groups. 2 to 2.5 mg/kg of propofol was used in all groups to induce anesthesia. One group received dexmedetomidine 0.2 μg/kg per hour infusion whereas the other group received dexmedetomidine 0.5 μg/kg per hour infusion. The control group received normal saline infusion. Results The mean age of patients was 41.02 ± 11.93. 33 patients in the dexmedetomidine 0.2 μg/kg/h group, 30 patients in the dexmedetomidine 0.5 μg/kg/h group and 27 patients in the placebo group. The lowest amount of bleeding was related to the dexmedetomidine 0.5 μg/kg/h group. The volume of bleeding between the three groups was significantly different (p = 0.012). The satisfaction of the surgeon in the dexmedetomidine 0.5 μg/kg/h group was more than other groups. There was a significant relationship between the satisfaction of the surgeon and the treatment groups (p < 0.001). The lowest duration of surgery was related to the dexmedetomidine 0.2 μg/kg/h group. The most Trinitroglycerin (TNG) consumption was in the placebo group and the highest dose of labetalol was in the dexmedetomidine 0.5 μg/kg/h group. There was no significant difference in the TNG and labetalol consumption between three groups. The lowest consumption of morphine and pethidine in the dexmedetomidine 0.5 μg/kg/h group. Conclusions Infusion of dexmedetomidine 0.5 μg/kg/h decreased blood loss and consumption of morphine and pethidine in patients who underwent endoscopic sinus surgery. |
| first_indexed | 2024-12-12T06:28:26Z |
| format | Article |
| id | doaj.art-fa870642fc2f43fdb6c8905d1f6ca719 |
| institution | Directory Open Access Journal |
| issn | 1754-9493 |
| language | English |
| last_indexed | 2024-12-12T06:28:26Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Patient Safety in Surgery |
| spelling | doaj.art-fa870642fc2f43fdb6c8905d1f6ca7192022-12-22T00:34:42ZengBMCPatient Safety in Surgery1754-94932020-10-011411710.1186/s13037-020-00264-4Effect of intraoperative dexmedetomidine infusion during functional endoscopic sinus surgery: a prospective cohort studyMohammad Reza Fazel0Zeynab Sadat Ahmadi1Hossein Akbari2Fahimeh Abam3Department of Radiology, Faculty of Medicine, Kashan University of Medical SciencesResearch Center of Biochemistry and Nutrition in Metabolic Disorder, Kashan University of Medical SciencesDepartment of Radiology, Faculty of Medicine, Kashan University of Medical SciencesDepartment of Radiology, Faculty of Medicine, Kashan University of Medical SciencesAbstract Background Dexmedetomidine, an α2 agonist, has well-known anesthetic and analgesic-sparing effects. We designed this study to evaluate the effect of intraoperative dexmedetomidine infusion on intra operative blood loss and postoperative pain in functional endoscopic sinus surgery. Methods This prospective cohort study included 90 patients planning to undergo endoscopic sinus surgery, who were randomly divided into three groups. 2 to 2.5 mg/kg of propofol was used in all groups to induce anesthesia. One group received dexmedetomidine 0.2 μg/kg per hour infusion whereas the other group received dexmedetomidine 0.5 μg/kg per hour infusion. The control group received normal saline infusion. Results The mean age of patients was 41.02 ± 11.93. 33 patients in the dexmedetomidine 0.2 μg/kg/h group, 30 patients in the dexmedetomidine 0.5 μg/kg/h group and 27 patients in the placebo group. The lowest amount of bleeding was related to the dexmedetomidine 0.5 μg/kg/h group. The volume of bleeding between the three groups was significantly different (p = 0.012). The satisfaction of the surgeon in the dexmedetomidine 0.5 μg/kg/h group was more than other groups. There was a significant relationship between the satisfaction of the surgeon and the treatment groups (p < 0.001). The lowest duration of surgery was related to the dexmedetomidine 0.2 μg/kg/h group. The most Trinitroglycerin (TNG) consumption was in the placebo group and the highest dose of labetalol was in the dexmedetomidine 0.5 μg/kg/h group. There was no significant difference in the TNG and labetalol consumption between three groups. The lowest consumption of morphine and pethidine in the dexmedetomidine 0.5 μg/kg/h group. Conclusions Infusion of dexmedetomidine 0.5 μg/kg/h decreased blood loss and consumption of morphine and pethidine in patients who underwent endoscopic sinus surgery.http://link.springer.com/article/10.1186/s13037-020-00264-4DexmedetomidineFunctional endoscopic sinus surgeryPainBlood loss |
| spellingShingle | Mohammad Reza Fazel Zeynab Sadat Ahmadi Hossein Akbari Fahimeh Abam Effect of intraoperative dexmedetomidine infusion during functional endoscopic sinus surgery: a prospective cohort study Patient Safety in Surgery Dexmedetomidine Functional endoscopic sinus surgery Pain Blood loss |
| title | Effect of intraoperative dexmedetomidine infusion during functional endoscopic sinus surgery: a prospective cohort study |
| title_full | Effect of intraoperative dexmedetomidine infusion during functional endoscopic sinus surgery: a prospective cohort study |
| title_fullStr | Effect of intraoperative dexmedetomidine infusion during functional endoscopic sinus surgery: a prospective cohort study |
| title_full_unstemmed | Effect of intraoperative dexmedetomidine infusion during functional endoscopic sinus surgery: a prospective cohort study |
| title_short | Effect of intraoperative dexmedetomidine infusion during functional endoscopic sinus surgery: a prospective cohort study |
| title_sort | effect of intraoperative dexmedetomidine infusion during functional endoscopic sinus surgery a prospective cohort study |
| topic | Dexmedetomidine Functional endoscopic sinus surgery Pain Blood loss |
| url | http://link.springer.com/article/10.1186/s13037-020-00264-4 |
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