Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood
Abstract Genetic effects on alcohol use can vary over time but are often examined using longitudinal models that predict a distal outcome at a single time point. The vast majority of these studies predominately examine effects using White, European American (EA) samples or examine the etiology of ge...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-01923-x |
| _version_ | 1818824859365408768 |
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| author | Kit K. Elam Thao Ha Zoe Neale Fazil Aliev Danielle Dick Kathryn Lemery-Chalfant |
| author_facet | Kit K. Elam Thao Ha Zoe Neale Fazil Aliev Danielle Dick Kathryn Lemery-Chalfant |
| author_sort | Kit K. Elam |
| collection | DOAJ |
| description | Abstract Genetic effects on alcohol use can vary over time but are often examined using longitudinal models that predict a distal outcome at a single time point. The vast majority of these studies predominately examine effects using White, European American (EA) samples or examine the etiology of genetic variants identified from EA samples in other racial/ethnic populations, leading to inconclusive findings about genetic effects on alcohol use. The current study examined how genetic influences on alcohol use varied by age across a 15 year period within a diverse ethnic/racial sample of adolescents. Using a multi-ethnic approach, polygenic risk scores were created for African American (AA, n = 192) and EA samples (n = 271) based on racially/ethnically aligned genome wide association studies. Age-varying associations between polygenic scores and alcohol use were examined from age 16 to 30 using time-varying effect models separately for AA and EA samples. Polygenic risk for alcohol use was found to be associated with alcohol use from age 22–27 in the AA sample and from age 24.50 to 29 in the EA sample. Results are discussed relative to the intersection of alcohol use and developmental genetic effects in diverse populations. |
| first_indexed | 2024-12-19T00:02:34Z |
| format | Article |
| id | doaj.art-fa872435f86b4b46a37139c6e0b979e8 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T00:02:34Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-fa872435f86b4b46a37139c6e0b979e82022-12-21T20:46:24ZengNature PortfolioScientific Reports2045-23222021-11-011111910.1038/s41598-021-01923-xAge varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthoodKit K. Elam0Thao Ha1Zoe Neale2Fazil Aliev3Danielle Dick4Kathryn Lemery-Chalfant5Department of Applied Health Science, Indiana UniversityDepartment of Psychology, Arizona State UniversityDepartment of Psychology, Virgina Commonwealth UniversityDepartment of Psychology, Virgina Commonwealth UniversityDepartment of Psychology, Virgina Commonwealth UniversityDepartment of Psychology, Arizona State UniversityAbstract Genetic effects on alcohol use can vary over time but are often examined using longitudinal models that predict a distal outcome at a single time point. The vast majority of these studies predominately examine effects using White, European American (EA) samples or examine the etiology of genetic variants identified from EA samples in other racial/ethnic populations, leading to inconclusive findings about genetic effects on alcohol use. The current study examined how genetic influences on alcohol use varied by age across a 15 year period within a diverse ethnic/racial sample of adolescents. Using a multi-ethnic approach, polygenic risk scores were created for African American (AA, n = 192) and EA samples (n = 271) based on racially/ethnically aligned genome wide association studies. Age-varying associations between polygenic scores and alcohol use were examined from age 16 to 30 using time-varying effect models separately for AA and EA samples. Polygenic risk for alcohol use was found to be associated with alcohol use from age 22–27 in the AA sample and from age 24.50 to 29 in the EA sample. Results are discussed relative to the intersection of alcohol use and developmental genetic effects in diverse populations.https://doi.org/10.1038/s41598-021-01923-x |
| spellingShingle | Kit K. Elam Thao Ha Zoe Neale Fazil Aliev Danielle Dick Kathryn Lemery-Chalfant Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood Scientific Reports |
| title | Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood |
| title_full | Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood |
| title_fullStr | Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood |
| title_full_unstemmed | Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood |
| title_short | Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood |
| title_sort | age varying polygenic effects on alcohol use in african americans and european americans from adolescence to adulthood |
| url | https://doi.org/10.1038/s41598-021-01923-x |
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