Estradiol increases risk of topoisomerase IIβ-mediated DNA strand breaks to initiate Xp11.2 translocation renal cell carcinoma

Estradiol increases risk of topoisomerase IIβ-mediated DNA strand breaks to initiate Xp11.2 translocation renal cell carcinoma

Abstract Background Xp11.2 translocation renal cell carcinoma (tRCC) is defined by translocation of the transcription factor E3 (TFE3) gene located on chromosome Xp11.2. Due to the high incidence in women, 17β-estradiol (E2) may be a factor influencing TFE3 breaks, and the topoisomerase II (TOP2) po...

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Bibliographic Details
Main Authors: Qiancheng Shi, Ning Liu, Lei Yang, Yi Chen, Yanwen Lu, Hongqian Guo, Xiaodong Han, Dongmei Li, Weidong Gan
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Cell Communication and Signaling
Subjects:
Renal cell carcinoma
Xp11.2
Estradiol
Estrogen receptor
Topoisomerase
TFE3
Online Access:https://doi.org/10.1186/s12964-021-00790-3

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