Effects of Endocrine-Disrupting Heavy Metals on Human Health
Heavy metals play an important endocrine-disrupting role in the health consequences. However, the endocrine-disrupting mechanism of heavy metals is unclear. There are long-term and low-level metal/element exposure scenes for the human body in real life. Therefore, animal models exposed to high doses...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/11/4/322 |
| _version_ | 1797603399576846336 |
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| author | Dongling Liu Qianhan Shi Cuiqing Liu Qinghua Sun Xiang Zeng |
| author_facet | Dongling Liu Qianhan Shi Cuiqing Liu Qinghua Sun Xiang Zeng |
| author_sort | Dongling Liu |
| collection | DOAJ |
| description | Heavy metals play an important endocrine-disrupting role in the health consequences. However, the endocrine-disrupting mechanism of heavy metals is unclear. There are long-term and low-level metal/element exposure scenes for the human body in real life. Therefore, animal models exposed to high doses of heavy metals may not provide key information to elucidate the underlying pathogeny of human diseases. This review collects current knowledge regarding the endocrine-disrupting roles of heavy metals such as lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), nickel (Ni), copper (Cu), zinc (Zn), and manganese (Mn), summarizes the possible molecular mechanisms of these endocrine-disrupting chemicals (EDCs), and briefly evaluates their endocrine toxicity on animals and humans. |
| first_indexed | 2024-03-11T04:28:39Z |
| format | Article |
| id | doaj.art-fa8a02ad90ea41898fd9ac7d0b17e808 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-11T04:28:39Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-fa8a02ad90ea41898fd9ac7d0b17e8082023-11-17T21:37:14ZengMDPI AGToxics2305-63042023-03-0111432210.3390/toxics11040322Effects of Endocrine-Disrupting Heavy Metals on Human HealthDongling Liu0Qianhan Shi1Cuiqing Liu2Qinghua Sun3Xiang Zeng4School of Basic Medical Science, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, ChinaSchool of Public Health, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, ChinaSchool of Public Health, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, ChinaSchool of Public Health, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, ChinaSchool of Public Health, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, ChinaHeavy metals play an important endocrine-disrupting role in the health consequences. However, the endocrine-disrupting mechanism of heavy metals is unclear. There are long-term and low-level metal/element exposure scenes for the human body in real life. Therefore, animal models exposed to high doses of heavy metals may not provide key information to elucidate the underlying pathogeny of human diseases. This review collects current knowledge regarding the endocrine-disrupting roles of heavy metals such as lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), nickel (Ni), copper (Cu), zinc (Zn), and manganese (Mn), summarizes the possible molecular mechanisms of these endocrine-disrupting chemicals (EDCs), and briefly evaluates their endocrine toxicity on animals and humans.https://www.mdpi.com/2305-6304/11/4/322endocrine disruptionheavy metalselementsthyroid hormoneestrogenhealth |
| spellingShingle | Dongling Liu Qianhan Shi Cuiqing Liu Qinghua Sun Xiang Zeng Effects of Endocrine-Disrupting Heavy Metals on Human Health Toxics endocrine disruption heavy metals elements thyroid hormone estrogen health |
| title | Effects of Endocrine-Disrupting Heavy Metals on Human Health |
| title_full | Effects of Endocrine-Disrupting Heavy Metals on Human Health |
| title_fullStr | Effects of Endocrine-Disrupting Heavy Metals on Human Health |
| title_full_unstemmed | Effects of Endocrine-Disrupting Heavy Metals on Human Health |
| title_short | Effects of Endocrine-Disrupting Heavy Metals on Human Health |
| title_sort | effects of endocrine disrupting heavy metals on human health |
| topic | endocrine disruption heavy metals elements thyroid hormone estrogen health |
| url | https://www.mdpi.com/2305-6304/11/4/322 |
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