Regulation of gene transcription by fatty acids
Dietary fat is well recognised as an important macronutrient that has major effects on growth, development and health of all animals including humans. The amount and type of fat in the diet impacts on many aspects of metabolism including lipoprotein pathways, lipid synthesis and oxidation, adipocyte...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2007-01-01
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| Series: | Animal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1751731107000675 |
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| author | A.M. Salter E.J. Tarling |
| author_facet | A.M. Salter E.J. Tarling |
| author_sort | A.M. Salter |
| collection | DOAJ |
| description | Dietary fat is well recognised as an important macronutrient that has major effects on growth, development and health of all animals including humans. The amount and type of fat in the diet impacts on many aspects of metabolism including lipoprotein pathways, lipid synthesis and oxidation, adipocyte differentiation and cholesterol metabolism. It has become increasingly apparent that many of these effects may be due to direct modulation of expression of key genes through the interaction of fatty acids with certain transcription factors. Peroxisome proliferator-activated receptors (PPARs), the liver X receptors (LXRs), hepatic nuclear factor 4 (HNF-4) and sterol regulatory binding proteins (SREBPs) represent four such factors. This review focuses on emerging evidence that the activity of these transcription factors are regulated by fatty acids and the interactions between them may be responsible for many of the effects of fatty acids on metabolism and the development of chronic disease. |
| first_indexed | 2024-12-19T10:49:11Z |
| format | Article |
| id | doaj.art-fa8b798681514d2685c947a34c089ed8 |
| institution | Directory Open Access Journal |
| issn | 1751-7311 |
| language | English |
| last_indexed | 2024-12-19T10:49:11Z |
| publishDate | 2007-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Animal |
| spelling | doaj.art-fa8b798681514d2685c947a34c089ed82022-12-21T20:25:07ZengElsevierAnimal1751-73112007-01-011913141320Regulation of gene transcription by fatty acidsA.M. Salter0E.J. Tarling1Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough DE74 2FW, UKDivision of Nutritional Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough DE74 2FW, UKDietary fat is well recognised as an important macronutrient that has major effects on growth, development and health of all animals including humans. The amount and type of fat in the diet impacts on many aspects of metabolism including lipoprotein pathways, lipid synthesis and oxidation, adipocyte differentiation and cholesterol metabolism. It has become increasingly apparent that many of these effects may be due to direct modulation of expression of key genes through the interaction of fatty acids with certain transcription factors. Peroxisome proliferator-activated receptors (PPARs), the liver X receptors (LXRs), hepatic nuclear factor 4 (HNF-4) and sterol regulatory binding proteins (SREBPs) represent four such factors. This review focuses on emerging evidence that the activity of these transcription factors are regulated by fatty acids and the interactions between them may be responsible for many of the effects of fatty acids on metabolism and the development of chronic disease.http://www.sciencedirect.com/science/article/pii/S1751731107000675gene expressiongeneslipidstranscription factors |
| spellingShingle | A.M. Salter E.J. Tarling Regulation of gene transcription by fatty acids Animal gene expression genes lipids transcription factors |
| title | Regulation of gene transcription by fatty acids |
| title_full | Regulation of gene transcription by fatty acids |
| title_fullStr | Regulation of gene transcription by fatty acids |
| title_full_unstemmed | Regulation of gene transcription by fatty acids |
| title_short | Regulation of gene transcription by fatty acids |
| title_sort | regulation of gene transcription by fatty acids |
| topic | gene expression genes lipids transcription factors |
| url | http://www.sciencedirect.com/science/article/pii/S1751731107000675 |
| work_keys_str_mv | AT amsalter regulationofgenetranscriptionbyfattyacids AT ejtarling regulationofgenetranscriptionbyfattyacids |