Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy.
Ultrathin bronchoscopy has been reported to have a higher diagnostic yield than thin bronchoscopy for small peripheral lung lesions in transbronchial biopsy under radial endobronchial ultrasonography (EBUS). However, data comparing the number of tumor cells in non-small cell lung cancer (NSCLC) are...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0290609 |
| _version_ | 1797690898588368896 |
|---|---|
| author | Atsuhiko Yatani Naoko Katsurada Takafumi Fukui Jun Yamada Hiroki Satoh Chihiro Mimura Daisuke Hazama Masatsugu Yamamoto Naoe Jimbo Tomonori Tanaka Motoko Tachihara |
| author_facet | Atsuhiko Yatani Naoko Katsurada Takafumi Fukui Jun Yamada Hiroki Satoh Chihiro Mimura Daisuke Hazama Masatsugu Yamamoto Naoe Jimbo Tomonori Tanaka Motoko Tachihara |
| author_sort | Atsuhiko Yatani |
| collection | DOAJ |
| description | Ultrathin bronchoscopy has been reported to have a higher diagnostic yield than thin bronchoscopy for small peripheral lung lesions in transbronchial biopsy under radial endobronchial ultrasonography (EBUS). However, data comparing the number of tumor cells in non-small cell lung cancer (NSCLC) are limited. We retrospectively compared the number of NSCLC tumor cells in peripheral lung lesions obtained using an ultrathin bronchoscope and a thin bronchoscope with radial EBUS between April 2020 and October 2021. In all patients, we used virtual bronchoscopic navigation (VBN) software, and guide sheaths were used in thin bronchoscopy cases. A total of 175 patients were enrolled in this study. Ultrathin bronchoscopy cases (n = 69) had lesions with a smaller diameter that are more peripherally located compared to thin bronchoscopy cases (n = 106) (median, 25.0 vs. 26.5 mm, mean bronchial generations accessed by bronchoscopy; 4.4±1.2 vs. 3.8±1.0, respectively; p<0.010). There were no significant differences in the overall diagnostic yield (ultrathin vs. thin bronchoscopy cases, 68.1% vs. 72.6%, p = 0.610) or diagnostic yield in only lung cancer cases (78.6% vs. 78.5%, p = 1.000). In histologically NSCLC cases (n = 102), the maximum number of tumor cells per slide as the primary endpoint was similar (average, 307.6±246.7 vs. 328.7±314.9, p = 0.710). The success rate of the Oncomine™ analysis did not differ significantly (80.0% vs. 55.6%, p = 0.247). The yield of NSCLC tumor cells was not different between the samples obtained by the ultrathin bronchoscope and those obtained by the thin bronchoscope. |
| first_indexed | 2024-03-12T02:05:45Z |
| format | Article |
| id | doaj.art-fa8d07fe552a40beb714ba54e43d185b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-12T02:05:45Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-fa8d07fe552a40beb714ba54e43d185b2023-09-07T05:31:26ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01188e029060910.1371/journal.pone.0290609Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy.Atsuhiko YataniNaoko KatsuradaTakafumi FukuiJun YamadaHiroki SatohChihiro MimuraDaisuke HazamaMasatsugu YamamotoNaoe JimboTomonori TanakaMotoko TachiharaUltrathin bronchoscopy has been reported to have a higher diagnostic yield than thin bronchoscopy for small peripheral lung lesions in transbronchial biopsy under radial endobronchial ultrasonography (EBUS). However, data comparing the number of tumor cells in non-small cell lung cancer (NSCLC) are limited. We retrospectively compared the number of NSCLC tumor cells in peripheral lung lesions obtained using an ultrathin bronchoscope and a thin bronchoscope with radial EBUS between April 2020 and October 2021. In all patients, we used virtual bronchoscopic navigation (VBN) software, and guide sheaths were used in thin bronchoscopy cases. A total of 175 patients were enrolled in this study. Ultrathin bronchoscopy cases (n = 69) had lesions with a smaller diameter that are more peripherally located compared to thin bronchoscopy cases (n = 106) (median, 25.0 vs. 26.5 mm, mean bronchial generations accessed by bronchoscopy; 4.4±1.2 vs. 3.8±1.0, respectively; p<0.010). There were no significant differences in the overall diagnostic yield (ultrathin vs. thin bronchoscopy cases, 68.1% vs. 72.6%, p = 0.610) or diagnostic yield in only lung cancer cases (78.6% vs. 78.5%, p = 1.000). In histologically NSCLC cases (n = 102), the maximum number of tumor cells per slide as the primary endpoint was similar (average, 307.6±246.7 vs. 328.7±314.9, p = 0.710). The success rate of the Oncomine™ analysis did not differ significantly (80.0% vs. 55.6%, p = 0.247). The yield of NSCLC tumor cells was not different between the samples obtained by the ultrathin bronchoscope and those obtained by the thin bronchoscope.https://doi.org/10.1371/journal.pone.0290609 |
| spellingShingle | Atsuhiko Yatani Naoko Katsurada Takafumi Fukui Jun Yamada Hiroki Satoh Chihiro Mimura Daisuke Hazama Masatsugu Yamamoto Naoe Jimbo Tomonori Tanaka Motoko Tachihara Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy. PLoS ONE |
| title | Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy. |
| title_full | Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy. |
| title_fullStr | Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy. |
| title_full_unstemmed | Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy. |
| title_short | Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy. |
| title_sort | diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions a comparison with thin bronchoscopy |
| url | https://doi.org/10.1371/journal.pone.0290609 |
| work_keys_str_mv | AT atsuhikoyatani diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT naokokatsurada diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT takafumifukui diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT junyamada diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT hirokisatoh diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT chihiromimura diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT daisukehazama diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT masatsuguyamamoto diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT naoejimbo diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT tomonoritanaka diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy AT motokotachihara diagnosticyieldandthenumberoftumorcellsofultrathinbronchoscopyforperipherallunglesionsacomparisonwiththinbronchoscopy |