The Optimal Permeation of Cyclic Boronates to Cross the Outer Membrane via the Porin Pathway

The Optimal Permeation of Cyclic Boronates to Cross the Outer Membrane via the Porin Pathway

We investigated the diffusion of three cyclic boronates formulated as beta-lactamase inhibitors through the porin OmpF to evaluate their potential to cross OM via the porin pathway. The three nonbeta-lactam molecules diffuse through the porin eyelet region with the same mechanism observed for beta-l...

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Bibliographic Details
Main Authors: Gian Marco Tuveri, Matteo Ceccarelli, Alessandro Pira, Igor V. Bodrenko
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Antibiotics
Subjects:
cyclic boronates
beta-lactamase inhibitors
porins
permeation
diffusion current
molecular dynamics simulations
Online Access:https://www.mdpi.com/2079-6382/11/7/840

Internet

https://www.mdpi.com/2079-6382/11/7/840

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