Attenuated initial serum ferritin concentration in critically ill coronavirus disease 2019 geriatric patients with comorbid psychiatric conditions
We examined the effects of psychiatric comorbidity, sex, and ICU admission on serum ferritin concentration in 628 elderly patients (79.7 ± 8.5 years) with positive SARS-CoV-2 PCR test. Hospitalization was required in 96% of patients and 17% required ICU admission. Patients with COVID-19 and psychiat...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1035986/full |
| _version_ | 1797985000982839296 |
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| author | Osama A. Abulseoud Osama A. Abulseoud Asmaa Yehia Claudine J. Egol Victor N. Nettey Mohamed Aly Yihuai Qu Aaron B. Skolnik Marie F. Grill Ayan Sen Terry D. Schneekloth |
| author_facet | Osama A. Abulseoud Osama A. Abulseoud Asmaa Yehia Claudine J. Egol Victor N. Nettey Mohamed Aly Yihuai Qu Aaron B. Skolnik Marie F. Grill Ayan Sen Terry D. Schneekloth |
| author_sort | Osama A. Abulseoud |
| collection | DOAJ |
| description | We examined the effects of psychiatric comorbidity, sex, and ICU admission on serum ferritin concentration in 628 elderly patients (79.7 ± 8.5 years) with positive SARS-CoV-2 PCR test. Hospitalization was required in 96% of patients and 17% required ICU admission. Patients with COVID-19 and psychiatric comorbidities (n = 212) compared to patients without psychiatric comorbidities (n = 416) had significantly lower ferritin concentration (570.4 ± 900.1 vs. 744.1 ± 965, P = 0.029), a greater incidence of delirium (22.6 vs. 14.4%, P = 0.013) and higher mortality (35.3 vs. 27.6%, P = 0.015). Furthermore, we found significant effects for sex (P = 0.002) and ICU admission (P = 0.007). Among patients without comorbid psychiatric conditions, males had significantly higher ferritin compared to females (1,098.3 ± 78.4 vs. 651.5 ± 94.4, P < 0.001). ICU patients without comorbid psychiatric conditions had significantly higher serum ferritin compared to ICU patients with comorbid psychiatric conditions: (1,126.6 ± 110.7 vs. 668.6 ± 156.5, P < 0.001). Our results suggest that the presence of comorbid psychiatric conditions in elderly patients with COVID-19 is associated with higher rates of delirium and mortality and lower ferritin levels during severe illness. Whether high serum ferritin is protective during severe infection requires further investigation. |
| first_indexed | 2024-04-11T07:11:47Z |
| format | Article |
| id | doaj.art-fa8ee63820d54f94ab2377b3bfe02449 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-11T07:11:47Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-fa8ee63820d54f94ab2377b3bfe024492022-12-22T04:38:12ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-11-011310.3389/fpsyt.2022.10359861035986Attenuated initial serum ferritin concentration in critically ill coronavirus disease 2019 geriatric patients with comorbid psychiatric conditionsOsama A. Abulseoud0Osama A. Abulseoud1Asmaa Yehia2Claudine J. Egol3Victor N. Nettey4Mohamed Aly5Yihuai Qu6Aaron B. Skolnik7Marie F. Grill8Ayan Sen9Terry D. Schneekloth10Department of Psychiatry and Psychology, Mayo Clinic Arizona, Phoenix, AZ, United StatesDepartment of Neuroscience, Mayo Clinic Graduate School of Biomedical Sciences, Collaborative Research Building (CRB), Scottsdale, AZ, United StatesDepartment of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura, EgyptDepartment of Psychiatry and Psychology, Mayo Clinic Arizona, Phoenix, AZ, United StatesDepartment of Psychiatry and Psychology, Mayo Clinic Arizona, Phoenix, AZ, United StatesDepartment of Cardiothoracic Surgery, Mayo Clinic Arizona, Phoenix, AZ, United StatesAlix School of Medicine at Mayo Clinic, Phoenix, AZ, United StatesDepartment of Critical Care, Mayo Clinic Arizona, Phoenix, AZ, United StatesDepartment of Neurology, Mayo Clinic Arizona, Phoenix, AZ, United StatesDepartment of Critical Care, Mayo Clinic Arizona, Phoenix, AZ, United StatesDepartment of Psychiatry and Psychology, Mayo Clinic Arizona, Phoenix, AZ, United StatesWe examined the effects of psychiatric comorbidity, sex, and ICU admission on serum ferritin concentration in 628 elderly patients (79.7 ± 8.5 years) with positive SARS-CoV-2 PCR test. Hospitalization was required in 96% of patients and 17% required ICU admission. Patients with COVID-19 and psychiatric comorbidities (n = 212) compared to patients without psychiatric comorbidities (n = 416) had significantly lower ferritin concentration (570.4 ± 900.1 vs. 744.1 ± 965, P = 0.029), a greater incidence of delirium (22.6 vs. 14.4%, P = 0.013) and higher mortality (35.3 vs. 27.6%, P = 0.015). Furthermore, we found significant effects for sex (P = 0.002) and ICU admission (P = 0.007). Among patients without comorbid psychiatric conditions, males had significantly higher ferritin compared to females (1,098.3 ± 78.4 vs. 651.5 ± 94.4, P < 0.001). ICU patients without comorbid psychiatric conditions had significantly higher serum ferritin compared to ICU patients with comorbid psychiatric conditions: (1,126.6 ± 110.7 vs. 668.6 ± 156.5, P < 0.001). Our results suggest that the presence of comorbid psychiatric conditions in elderly patients with COVID-19 is associated with higher rates of delirium and mortality and lower ferritin levels during severe illness. Whether high serum ferritin is protective during severe infection requires further investigation.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1035986/fullferritinCOVID-19deliriumcritical illness *mortalitygeriatricpsychiatric disorders |
| spellingShingle | Osama A. Abulseoud Osama A. Abulseoud Asmaa Yehia Claudine J. Egol Victor N. Nettey Mohamed Aly Yihuai Qu Aaron B. Skolnik Marie F. Grill Ayan Sen Terry D. Schneekloth Attenuated initial serum ferritin concentration in critically ill coronavirus disease 2019 geriatric patients with comorbid psychiatric conditions Frontiers in Psychiatry ferritin COVID-19 delirium critical illness *mortality geriatric psychiatric disorders |
| title | Attenuated initial serum ferritin concentration in critically ill coronavirus disease 2019 geriatric patients with comorbid psychiatric conditions |
| title_full | Attenuated initial serum ferritin concentration in critically ill coronavirus disease 2019 geriatric patients with comorbid psychiatric conditions |
| title_fullStr | Attenuated initial serum ferritin concentration in critically ill coronavirus disease 2019 geriatric patients with comorbid psychiatric conditions |
| title_full_unstemmed | Attenuated initial serum ferritin concentration in critically ill coronavirus disease 2019 geriatric patients with comorbid psychiatric conditions |
| title_short | Attenuated initial serum ferritin concentration in critically ill coronavirus disease 2019 geriatric patients with comorbid psychiatric conditions |
| title_sort | attenuated initial serum ferritin concentration in critically ill coronavirus disease 2019 geriatric patients with comorbid psychiatric conditions |
| topic | ferritin COVID-19 delirium critical illness *mortality geriatric psychiatric disorders |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1035986/full |
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