Treatment of severe idiopathic hypoparathyroidism: a case report
Hypoparathyroidism is a rare disorder characterized by parathyroid hormone (PTH) insufficiency, the development of hypocalcemia and alteration of bone tissue remodeling. The goal of treatment is to normalize the indicators of calcium-phosphorus metabolism and leveling of clinical manifestations....
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2018-12-01
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| Series: | Остеопороз и остеопатии |
| Subjects: | |
| Online Access: | https://osteo-endojournals.ru/osteo/article/viewFile/9878/7489 |
| _version_ | 1818622712029904896 |
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| author | Diliara Sh. Umiarova Tatiana A. Grebennikova Natalya V. Tarbaeva Zhanna E. Belaya |
| author_facet | Diliara Sh. Umiarova Tatiana A. Grebennikova Natalya V. Tarbaeva Zhanna E. Belaya |
| author_sort | Diliara Sh. Umiarova |
| collection | DOAJ |
| description | Hypoparathyroidism is a rare disorder characterized by parathyroid hormone (PTH) insufficiency, the development of hypocalcemia and alteration of bone tissue remodeling.
The goal of treatment is to normalize the indicators of calcium-phosphorus metabolism and leveling of clinical manifestations. Standard treatment of hypoparathyroidism consists of oral calcium and active forms of vitamin D, in doses necessary to maintain calcium levels at the lower limit of the reference interval.
Nevertheless, treatment of the disease exerts certain difficulties in clinical practice. At the same time, compensation of the hypoparathyroidism is necessary to prevent ectopic calcification. Daily subcutaneous delivery of PTH (184) and PTH (134) has emerged as a promising therapeutic tool. However, its use should be restricted to patients insufficiently controlled with the standard treatment with active vitamin D and calcium.
We present a clinical case of idiopathic hypoparathyroidism with severe clinical presentation of hypocalcaemia and ectopic calcification. Idiopathic hypoparathyroidism is a consequence of autoimmune destruction of the parathyroid glands and is exhibited by excluding all known causes of hypoparathyroidism.
PTH (134) treatment allowed reducing the dose of calcium and vitamin D and achieving compensation of the disease. |
| first_indexed | 2024-12-16T18:29:31Z |
| format | Article |
| id | doaj.art-fa8f1c16139943028e2ebd5e33e2a550 |
| institution | Directory Open Access Journal |
| issn | 2072-2680 2311-0716 |
| language | English |
| last_indexed | 2024-12-16T18:29:31Z |
| publishDate | 2018-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Остеопороз и остеопатии |
| spelling | doaj.art-fa8f1c16139943028e2ebd5e33e2a5502022-12-21T22:21:20ZengEndocrinology Research CentreОстеопороз и остеопатии2072-26802311-07162018-12-01212364010.14341/osteo98788605Treatment of severe idiopathic hypoparathyroidism: a case reportDiliara Sh. Umiarova0Tatiana A. Grebennikova1Natalya V. Tarbaeva2Zhanna E. Belaya3Endocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreHypoparathyroidism is a rare disorder characterized by parathyroid hormone (PTH) insufficiency, the development of hypocalcemia and alteration of bone tissue remodeling. The goal of treatment is to normalize the indicators of calcium-phosphorus metabolism and leveling of clinical manifestations. Standard treatment of hypoparathyroidism consists of oral calcium and active forms of vitamin D, in doses necessary to maintain calcium levels at the lower limit of the reference interval. Nevertheless, treatment of the disease exerts certain difficulties in clinical practice. At the same time, compensation of the hypoparathyroidism is necessary to prevent ectopic calcification. Daily subcutaneous delivery of PTH (184) and PTH (134) has emerged as a promising therapeutic tool. However, its use should be restricted to patients insufficiently controlled with the standard treatment with active vitamin D and calcium. We present a clinical case of idiopathic hypoparathyroidism with severe clinical presentation of hypocalcaemia and ectopic calcification. Idiopathic hypoparathyroidism is a consequence of autoimmune destruction of the parathyroid glands and is exhibited by excluding all known causes of hypoparathyroidism. PTH (134) treatment allowed reducing the dose of calcium and vitamin D and achieving compensation of the disease.https://osteo-endojournals.ru/osteo/article/viewFile/9878/7489hypoparathyroidismhypocalcaemiahyperphosphatemiaectopic calcificationteriparatideсase report |
| spellingShingle | Diliara Sh. Umiarova Tatiana A. Grebennikova Natalya V. Tarbaeva Zhanna E. Belaya Treatment of severe idiopathic hypoparathyroidism: a case report Остеопороз и остеопатии hypoparathyroidism hypocalcaemia hyperphosphatemia ectopic calcification teriparatide сase report |
| title | Treatment of severe idiopathic hypoparathyroidism: a case report |
| title_full | Treatment of severe idiopathic hypoparathyroidism: a case report |
| title_fullStr | Treatment of severe idiopathic hypoparathyroidism: a case report |
| title_full_unstemmed | Treatment of severe idiopathic hypoparathyroidism: a case report |
| title_short | Treatment of severe idiopathic hypoparathyroidism: a case report |
| title_sort | treatment of severe idiopathic hypoparathyroidism a case report |
| topic | hypoparathyroidism hypocalcaemia hyperphosphatemia ectopic calcification teriparatide сase report |
| url | https://osteo-endojournals.ru/osteo/article/viewFile/9878/7489 |
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