Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy
Targeting altered tumour metabolism is an emerging therapeutic strategy for cancer treatment. The metabolic reprogramming that accompanies the development of malignancy creates targetable differences between cancer cells and normal cells, which may be exploited for therapy. There is also emerging ev...
| Váldodahkkit: | , , , , , , |
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| Materiálatiipa: | Artihkal |
| Giella: | English |
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MDPI AG
2020-10-01
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| Ráidu: | Molecules |
| Fáttát: | |
| Liŋkkat: | https://www.mdpi.com/1420-3049/25/20/4831 |
| _version_ | 1827703885610876928 |
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| author | Jiaqi Li Jie Qing Eu Li Ren Kong Lingzhi Wang Yaw Chyn Lim Boon Cher Goh Andrea L. A. Wong |
| author_facet | Jiaqi Li Jie Qing Eu Li Ren Kong Lingzhi Wang Yaw Chyn Lim Boon Cher Goh Andrea L. A. Wong |
| author_sort | Jiaqi Li |
| collection | DOAJ |
| description | Targeting altered tumour metabolism is an emerging therapeutic strategy for cancer treatment. The metabolic reprogramming that accompanies the development of malignancy creates targetable differences between cancer cells and normal cells, which may be exploited for therapy. There is also emerging evidence regarding the role of stromal components, creating an intricate metabolic network consisting of cancer cells, cancer-associated fibroblasts, endothelial cells, immune cells, and cancer stem cells. This metabolic rewiring and crosstalk with the tumour microenvironment play a key role in cell proliferation, metastasis, and the development of treatment resistance. In this review, we will discuss therapeutic opportunities, which arise from dysregulated metabolism and metabolic crosstalk, highlighting strategies that may aid in the precision targeting of altered tumour metabolism with a focus on combinatorial therapeutic strategies. |
| first_indexed | 2024-03-10T15:29:09Z |
| format | Article |
| id | doaj.art-fa8f63fe72d24b51a0510ea9aec3d75e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T15:29:09Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-fa8f63fe72d24b51a0510ea9aec3d75e2023-11-20T17:52:20ZengMDPI AGMolecules1420-30492020-10-012520483110.3390/molecules25204831Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer TherapyJiaqi Li0Jie Qing Eu1Li Ren Kong2Lingzhi Wang3Yaw Chyn Lim4Boon Cher Goh5Andrea L. A. Wong6School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UKCancer Science Institute of Singapore, National University of Singapore, Singapore 117599, SingaporeCancer Science Institute of Singapore, National University of Singapore, Singapore 117599, SingaporeCancer Science Institute of Singapore, National University of Singapore, Singapore 117599, SingaporeCancer Science Institute of Singapore, National University of Singapore, Singapore 117599, SingaporeCancer Science Institute of Singapore, National University of Singapore, Singapore 117599, SingaporeCancer Science Institute of Singapore, National University of Singapore, Singapore 117599, SingaporeTargeting altered tumour metabolism is an emerging therapeutic strategy for cancer treatment. The metabolic reprogramming that accompanies the development of malignancy creates targetable differences between cancer cells and normal cells, which may be exploited for therapy. There is also emerging evidence regarding the role of stromal components, creating an intricate metabolic network consisting of cancer cells, cancer-associated fibroblasts, endothelial cells, immune cells, and cancer stem cells. This metabolic rewiring and crosstalk with the tumour microenvironment play a key role in cell proliferation, metastasis, and the development of treatment resistance. In this review, we will discuss therapeutic opportunities, which arise from dysregulated metabolism and metabolic crosstalk, highlighting strategies that may aid in the precision targeting of altered tumour metabolism with a focus on combinatorial therapeutic strategies.https://www.mdpi.com/1420-3049/25/20/4831cancer cell metabolismtumour microenvironmentmetabolic reprogrammingtargeted therapyimmunotherapy |
| spellingShingle | Jiaqi Li Jie Qing Eu Li Ren Kong Lingzhi Wang Yaw Chyn Lim Boon Cher Goh Andrea L. A. Wong Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy Molecules cancer cell metabolism tumour microenvironment metabolic reprogramming targeted therapy immunotherapy |
| title | Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy |
| title_full | Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy |
| title_fullStr | Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy |
| title_full_unstemmed | Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy |
| title_short | Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy |
| title_sort | targeting metabolism in cancer cells and the tumour microenvironment for cancer therapy |
| topic | cancer cell metabolism tumour microenvironment metabolic reprogramming targeted therapy immunotherapy |
| url | https://www.mdpi.com/1420-3049/25/20/4831 |
| work_keys_str_mv | AT jiaqili targetingmetabolismincancercellsandthetumourmicroenvironmentforcancertherapy AT jieqingeu targetingmetabolismincancercellsandthetumourmicroenvironmentforcancertherapy AT lirenkong targetingmetabolismincancercellsandthetumourmicroenvironmentforcancertherapy AT lingzhiwang targetingmetabolismincancercellsandthetumourmicroenvironmentforcancertherapy AT yawchynlim targetingmetabolismincancercellsandthetumourmicroenvironmentforcancertherapy AT boonchergoh targetingmetabolismincancercellsandthetumourmicroenvironmentforcancertherapy AT andrealawong targetingmetabolismincancercellsandthetumourmicroenvironmentforcancertherapy |