Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review
Sarcopenia is a multifactorial condition related to the loss of muscle mass and strength due to aging, eating habits, physical inactivity, or even caused by another disease. Affected individuals have a higher risk of falls and may be associated with heart disease, respiratory diseases, cognitive imp...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/1/136 |
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| author | Rodrigo Haber Mellen Otávio Simões Girotto Eduarda Boni Marques Lucas Fornari Laurindo Paulo Cesar Grippa Claudemir Gregório Mendes Lorena Natalino Haber Garcia Marcelo Dib Bechara Sandra Maria Barbalho Renata Vargas Sinatora Jesselina Francisco dos Santos Haber Uri Adrian P. Flato Patricia Cincotto dos Santos Bueno Claudia Rucco Penteado Detregiachi Karina Quesada |
| author_facet | Rodrigo Haber Mellen Otávio Simões Girotto Eduarda Boni Marques Lucas Fornari Laurindo Paulo Cesar Grippa Claudemir Gregório Mendes Lorena Natalino Haber Garcia Marcelo Dib Bechara Sandra Maria Barbalho Renata Vargas Sinatora Jesselina Francisco dos Santos Haber Uri Adrian P. Flato Patricia Cincotto dos Santos Bueno Claudia Rucco Penteado Detregiachi Karina Quesada |
| author_sort | Rodrigo Haber Mellen |
| collection | DOAJ |
| description | Sarcopenia is a multifactorial condition related to the loss of muscle mass and strength due to aging, eating habits, physical inactivity, or even caused by another disease. Affected individuals have a higher risk of falls and may be associated with heart disease, respiratory diseases, cognitive impairment, and consequently an increased risk of hospitalization, in addition to causing an economic impact due to the high cost of care during the stay in hospitals. The standardization of appropriate treatment for patients with sarcopenia that could help reduce pathology-related morbidity is necessary. For these reasons, this study aimed to perform a systematic review of the role of nutrition and drugs that could ameliorate the health and quality of life of sarcopenic patients and PRISMA guidelines were followed. Lifestyle interventions have shown a profound impact on sarcopenia treatment but using supplements and different drugs can also impact skeletal muscle maintenance. Creatine, leucine, branched-chain amino acids, omega 3, and vitamin D can show benefits. Although with controversial results, medications such as Metformin, GLP-1, losartan, statin, growth hormone, and dipeptidyl peptidase 4 inhibitors have also been considered and can alter the sarcopenic’s metabolic parameters, protect against cardiovascular diseases and outcomes, while protecting muscles. |
| first_indexed | 2024-03-09T13:29:45Z |
| format | Article |
| id | doaj.art-fa902ba71506432e9a93bcaa10f8e9b2 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T13:29:45Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-fa902ba71506432e9a93bcaa10f8e9b22023-11-30T21:19:56ZengMDPI AGBiomedicines2227-90592023-01-0111113610.3390/biomedicines11010136Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic ReviewRodrigo Haber Mellen0Otávio Simões Girotto1Eduarda Boni Marques2Lucas Fornari Laurindo3Paulo Cesar Grippa4Claudemir Gregório Mendes5Lorena Natalino Haber Garcia6Marcelo Dib Bechara7Sandra Maria Barbalho8Renata Vargas Sinatora9Jesselina Francisco dos Santos Haber10Uri Adrian P. Flato11Patricia Cincotto dos Santos Bueno12Claudia Rucco Penteado Detregiachi13Karina Quesada14Department of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), São Paulo 17525-902, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), São Paulo 17525-902, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), São Paulo 17525-902, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), São Paulo 17525-902, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation—University of Marília (UNIMAR), São Paulo 17525-902, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), São Paulo 17525-902, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), São Paulo 17525-902, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), São Paulo 17525-902, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), São Paulo 17525-902, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), São Paulo 17525-902, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), São Paulo 17525-902, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), São Paulo 17525-902, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), São Paulo 17525-902, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation—University of Marília (UNIMAR), São Paulo 17525-902, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, University of Marília (UNIMAR), São Paulo 17525-902, BrazilSarcopenia is a multifactorial condition related to the loss of muscle mass and strength due to aging, eating habits, physical inactivity, or even caused by another disease. Affected individuals have a higher risk of falls and may be associated with heart disease, respiratory diseases, cognitive impairment, and consequently an increased risk of hospitalization, in addition to causing an economic impact due to the high cost of care during the stay in hospitals. The standardization of appropriate treatment for patients with sarcopenia that could help reduce pathology-related morbidity is necessary. For these reasons, this study aimed to perform a systematic review of the role of nutrition and drugs that could ameliorate the health and quality of life of sarcopenic patients and PRISMA guidelines were followed. Lifestyle interventions have shown a profound impact on sarcopenia treatment but using supplements and different drugs can also impact skeletal muscle maintenance. Creatine, leucine, branched-chain amino acids, omega 3, and vitamin D can show benefits. Although with controversial results, medications such as Metformin, GLP-1, losartan, statin, growth hormone, and dipeptidyl peptidase 4 inhibitors have also been considered and can alter the sarcopenic’s metabolic parameters, protect against cardiovascular diseases and outcomes, while protecting muscles.https://www.mdpi.com/2227-9059/11/1/136sarcopeniainflammationamino acidsdrugs |
| spellingShingle | Rodrigo Haber Mellen Otávio Simões Girotto Eduarda Boni Marques Lucas Fornari Laurindo Paulo Cesar Grippa Claudemir Gregório Mendes Lorena Natalino Haber Garcia Marcelo Dib Bechara Sandra Maria Barbalho Renata Vargas Sinatora Jesselina Francisco dos Santos Haber Uri Adrian P. Flato Patricia Cincotto dos Santos Bueno Claudia Rucco Penteado Detregiachi Karina Quesada Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review Biomedicines sarcopenia inflammation amino acids drugs |
| title | Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review |
| title_full | Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review |
| title_fullStr | Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review |
| title_full_unstemmed | Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review |
| title_short | Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review |
| title_sort | insights into pathogenesis nutritional and drug approach in sarcopenia a systematic review |
| topic | sarcopenia inflammation amino acids drugs |
| url | https://www.mdpi.com/2227-9059/11/1/136 |
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