Impaired cardiorespiratory and neuromuscular fitness in children and adolescents with juvenile idiopathic arthritis: a cross-sectional case–control study in the era of biologic drug therapies
Abstract Background In recent years, biologic drug therapies have altered the course of juvenile idiopathic arthritis (JIA) possibly also improving the patients’ physical fitness. However, studies measuring both cardiorespiratory and muscular fitness in children with JIA are sparse and have failed t...
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Pediatric Rheumatology Online Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12969-023-00808-9 |
| _version_ | 1797865371350335488 |
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| author | Kati Räsänen Kati Markula-Patjas Saija Kantanen Kalle Sipilä Timo A. Lakka Pekka Arikoski Eija Piippo-Savolainen |
| author_facet | Kati Räsänen Kati Markula-Patjas Saija Kantanen Kalle Sipilä Timo A. Lakka Pekka Arikoski Eija Piippo-Savolainen |
| author_sort | Kati Räsänen |
| collection | DOAJ |
| description | Abstract Background In recent years, biologic drug therapies have altered the course of juvenile idiopathic arthritis (JIA) possibly also improving the patients’ physical fitness. However, studies measuring both cardiorespiratory and muscular fitness in children with JIA are sparse and have failed to show consistent results. Our aim was to assess both cardiorespiratory and neuromuscular fitness and contributing factors in children and adolescents with JIA in the era of biologic drug therapies. Methods This cross-sectional study consisted of 73 JIA patients (25 boys, 48 girls) aged 6.8- 17.5 years and 73 healthy age- and sex-matched controls, investigated in 2017–2019. Cardiorespiratory fitness was assessed by maximal ergospirometry and neuromuscular fitness by speed, agility, balance, and muscle strength tests. Results Means (± SD) of maximal workload (Wmax/kg) and peak oxygen uptake (VO2peak/kg,) were lower in JIA patients than in controls (Wmax/kg: 2.80 ± 0.54 vs. 3.14 ± 0.50 Watts, p < 0.01; VO2peak/kg: 38.7 ± 7.53 vs. 45.8 ± 6.59 ml/min/kg, p < 0.01). Shuttle-run, sit-up and standing long jump test results were lower in JIA patients than in controls (p < 0.01). Mean (± SD) daily activity was lower (89.0 ± 44.7 vs. 112.7 ± 62.1 min/day, p < 0.05), and sedentary time was higher (427 ± 213 vs. 343 ± 211 min/day, p < 0.05) in JIA patients compared to controls. Physical activity and cardiorespiratory or neuromuscular fitness were not associated with disease activity. Conclusions JIA patients were physically less active and had lower cardiorespiratory and neuromuscular fitness than their same aged controls with no JIA. Therefore, JIA patients should be encouraged to engage in physical activities as a part of their multidisciplinary treatment protocols to prevent adverse health risks of low physical activity and fitness. |
| first_indexed | 2024-04-09T23:06:57Z |
| format | Article |
| id | doaj.art-fa9243d8fad9494297b6b928943bc097 |
| institution | Directory Open Access Journal |
| issn | 1546-0096 |
| language | English |
| last_indexed | 2024-04-09T23:06:57Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Pediatric Rheumatology Online Journal |
| spelling | doaj.art-fa9243d8fad9494297b6b928943bc0972023-03-22T10:40:40ZengBMCPediatric Rheumatology Online Journal1546-00962023-03-0121111110.1186/s12969-023-00808-9Impaired cardiorespiratory and neuromuscular fitness in children and adolescents with juvenile idiopathic arthritis: a cross-sectional case–control study in the era of biologic drug therapiesKati Räsänen0Kati Markula-Patjas1Saija Kantanen2Kalle Sipilä3Timo A. Lakka4Pekka Arikoski5Eija Piippo-Savolainen6Pediatric Research Unit, University of Eastern Finland and Kuopio University HospitalCenter for Child Health Research, Tampere University and Department of Pediatrics, Tampere University HospitalCenter for Child Health Research, Tampere University and Department of Pediatrics, Tampere University HospitalDepartment of Clinical Physiology and Nuclear Medicine, Faculty of Medicine and Health Technology, Tampere University and Tampere University HospitalInstitute of Biomedicine, School of Medicine, University of Eastern FinlandPediatric Research Unit, University of Eastern Finland and Kuopio University HospitalPediatric Research Unit, University of Eastern Finland and Kuopio University HospitalAbstract Background In recent years, biologic drug therapies have altered the course of juvenile idiopathic arthritis (JIA) possibly also improving the patients’ physical fitness. However, studies measuring both cardiorespiratory and muscular fitness in children with JIA are sparse and have failed to show consistent results. Our aim was to assess both cardiorespiratory and neuromuscular fitness and contributing factors in children and adolescents with JIA in the era of biologic drug therapies. Methods This cross-sectional study consisted of 73 JIA patients (25 boys, 48 girls) aged 6.8- 17.5 years and 73 healthy age- and sex-matched controls, investigated in 2017–2019. Cardiorespiratory fitness was assessed by maximal ergospirometry and neuromuscular fitness by speed, agility, balance, and muscle strength tests. Results Means (± SD) of maximal workload (Wmax/kg) and peak oxygen uptake (VO2peak/kg,) were lower in JIA patients than in controls (Wmax/kg: 2.80 ± 0.54 vs. 3.14 ± 0.50 Watts, p < 0.01; VO2peak/kg: 38.7 ± 7.53 vs. 45.8 ± 6.59 ml/min/kg, p < 0.01). Shuttle-run, sit-up and standing long jump test results were lower in JIA patients than in controls (p < 0.01). Mean (± SD) daily activity was lower (89.0 ± 44.7 vs. 112.7 ± 62.1 min/day, p < 0.05), and sedentary time was higher (427 ± 213 vs. 343 ± 211 min/day, p < 0.05) in JIA patients compared to controls. Physical activity and cardiorespiratory or neuromuscular fitness were not associated with disease activity. Conclusions JIA patients were physically less active and had lower cardiorespiratory and neuromuscular fitness than their same aged controls with no JIA. Therefore, JIA patients should be encouraged to engage in physical activities as a part of their multidisciplinary treatment protocols to prevent adverse health risks of low physical activity and fitness.https://doi.org/10.1186/s12969-023-00808-9Juvenile idiopathic arthritisDisease activityPhysical activityCardiorespiratory fitnessNeuromuscular fitness |
| spellingShingle | Kati Räsänen Kati Markula-Patjas Saija Kantanen Kalle Sipilä Timo A. Lakka Pekka Arikoski Eija Piippo-Savolainen Impaired cardiorespiratory and neuromuscular fitness in children and adolescents with juvenile idiopathic arthritis: a cross-sectional case–control study in the era of biologic drug therapies Pediatric Rheumatology Online Journal Juvenile idiopathic arthritis Disease activity Physical activity Cardiorespiratory fitness Neuromuscular fitness |
| title | Impaired cardiorespiratory and neuromuscular fitness in children and adolescents with juvenile idiopathic arthritis: a cross-sectional case–control study in the era of biologic drug therapies |
| title_full | Impaired cardiorespiratory and neuromuscular fitness in children and adolescents with juvenile idiopathic arthritis: a cross-sectional case–control study in the era of biologic drug therapies |
| title_fullStr | Impaired cardiorespiratory and neuromuscular fitness in children and adolescents with juvenile idiopathic arthritis: a cross-sectional case–control study in the era of biologic drug therapies |
| title_full_unstemmed | Impaired cardiorespiratory and neuromuscular fitness in children and adolescents with juvenile idiopathic arthritis: a cross-sectional case–control study in the era of biologic drug therapies |
| title_short | Impaired cardiorespiratory and neuromuscular fitness in children and adolescents with juvenile idiopathic arthritis: a cross-sectional case–control study in the era of biologic drug therapies |
| title_sort | impaired cardiorespiratory and neuromuscular fitness in children and adolescents with juvenile idiopathic arthritis a cross sectional case control study in the era of biologic drug therapies |
| topic | Juvenile idiopathic arthritis Disease activity Physical activity Cardiorespiratory fitness Neuromuscular fitness |
| url | https://doi.org/10.1186/s12969-023-00808-9 |
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