Current understanding of genetic associations with delayed hypersensitivity reactions induced by antibiotics and anti-osteoporotic drugs
Drug-induced delayed hypersensitivity reactions (DHRs) is still a clinical and healthcare burden in every country. Increasing reports of DHRs have caught our attention to explore the genetic relationship, especially life-threatening severe cutaneous adverse drug reactions (SCARs), including acute ge...
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Frontiers Media S.A.
2023-04-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1183491/full |
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| author | Chih-Hsuan Wung Chuang-Wei Wang Chuang-Wei Wang Chuang-Wei Wang Chuang-Wei Wang Kuo-Chu Lai Kuo-Chu Lai Kuo-Chu Lai Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Wei-Ti Chen Wei-Ti Chen Wei-Ti Chen Shuen-Iu Hung Shuen-Iu Hung Shuen-Iu Hung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Taiwan Severe Cutaneous Adverse Reaction Consortium |
| author_facet | Chih-Hsuan Wung Chuang-Wei Wang Chuang-Wei Wang Chuang-Wei Wang Chuang-Wei Wang Kuo-Chu Lai Kuo-Chu Lai Kuo-Chu Lai Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Wei-Ti Chen Wei-Ti Chen Wei-Ti Chen Shuen-Iu Hung Shuen-Iu Hung Shuen-Iu Hung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Taiwan Severe Cutaneous Adverse Reaction Consortium |
| author_sort | Chih-Hsuan Wung |
| collection | DOAJ |
| description | Drug-induced delayed hypersensitivity reactions (DHRs) is still a clinical and healthcare burden in every country. Increasing reports of DHRs have caught our attention to explore the genetic relationship, especially life-threatening severe cutaneous adverse drug reactions (SCARs), including acute generalized exanthematous pustulosis (AGEP), drug reactions with eosinophilia and systemic symptoms (DRESS), Stevens–Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). In recent years, many studies have investigated the immune mechanism and genetic markers of DHRs. Besides, several studies have stated the associations between antibiotics-as well as anti-osteoporotic drugs (AOD)-induced SCARs and specific human leukocyte antigens (HLA) alleles. Strong associations between drugs and HLA alleles such as co-trimoxazole-induced DRESS and HLA-B*13:01 (Odds ratio (OR) = 45), dapsone-DRESS and HLA-B*13:01 (OR = 122.1), vancomycin-DRESS and HLA-A*32:01 (OR = 403), clindamycin-DHRs and HLA-B*15:27 (OR = 55.6), and strontium ranelate (SR)-SJS/TEN and HLA-A*33:03 (OR = 25.97) are listed. We summarized the immune mechanism of SCARs, update the latest knowledge of pharmacogenomics of antibiotics- and AOD-induced SCARs, and indicate the potential clinical use of these genetic markers for SCARs prevention in this mini review article. |
| first_indexed | 2024-04-09T15:53:37Z |
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| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-09T15:53:37Z |
| publishDate | 2023-04-01 |
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| series | Frontiers in Pharmacology |
| spelling | doaj.art-fa92ed091e0247a9bf442fb92c13bf472023-04-26T05:10:41ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-04-011410.3389/fphar.2023.11834911183491Current understanding of genetic associations with delayed hypersensitivity reactions induced by antibiotics and anti-osteoporotic drugsChih-Hsuan Wung0Chuang-Wei Wang1Chuang-Wei Wang2Chuang-Wei Wang3Chuang-Wei Wang4Kuo-Chu Lai5Kuo-Chu Lai6Kuo-Chu Lai7Chun-Bing Chen8Chun-Bing Chen9Chun-Bing Chen10Chun-Bing Chen11Chun-Bing Chen12Chun-Bing Chen13Chun-Bing Chen14Chun-Bing Chen15Wei-Ti Chen16Wei-Ti Chen17Wei-Ti Chen18Shuen-Iu Hung19Shuen-Iu Hung20Shuen-Iu Hung21Wen-Hung Chung22Wen-Hung Chung23Wen-Hung Chung24Wen-Hung Chung25Wen-Hung Chung26Wen-Hung Chung27Wen-Hung Chung28Wen-Hung Chung29Wen-Hung Chung30Wen-Hung Chung31Wen-Hung Chung32Taiwan Severe Cutaneous Adverse Reaction ConsortiumChang Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei and Keelung, TaiwanCancer Vaccine and Immune Cell Therapy Core Laboratory, Department of Medical Research, Chang Gung Memorial Hospital, Taoyuan, TaiwanChang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, TaiwanDepartment of Dermatology, Xiamen Chang Gung Hospital, Xiamen, ChinaDepartment of Physiology and Pharmacology, College of Medicine, Chang Gung University, Taoyuan, TaiwanGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanDivision of Hematology and Oncology, Department of Internal Medicine, New Taipei Municipal TuCheng Hospital (Built and Operated by Chang Gung Medical Foundation), New Taipei City, TaiwanDepartment of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei and Keelung, TaiwanCancer Vaccine and Immune Cell Therapy Core Laboratory, Department of Medical Research, Chang Gung Memorial Hospital, Taoyuan, TaiwanChang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, TaiwanDepartment of Dermatology, Xiamen Chang Gung Hospital, Xiamen, ChinaCollege of Medicine, Chang Gung University, Taoyuan, Taiwan0Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan1Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou, Taiwan2Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei and Keelung, TaiwanDepartment of Dermatology, Xiamen Chang Gung Hospital, Xiamen, ChinaCollege of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei and Keelung, TaiwanCancer Vaccine and Immune Cell Therapy Core Laboratory, Department of Medical Research, Chang Gung Memorial Hospital, Taoyuan, Taiwan3Institute of Pharmacology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei and Keelung, TaiwanCancer Vaccine and Immune Cell Therapy Core Laboratory, Department of Medical Research, Chang Gung Memorial Hospital, Taoyuan, TaiwanChang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, TaiwanDepartment of Dermatology, Xiamen Chang Gung Hospital, Xiamen, ChinaCollege of Medicine, Chang Gung University, Taoyuan, Taiwan0Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan1Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou, Taiwan2Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan4Department of Dermatology, Beijing Tsinghua Chang Gung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China5Department of Dermatology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China6Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, TaiwanDrug-induced delayed hypersensitivity reactions (DHRs) is still a clinical and healthcare burden in every country. Increasing reports of DHRs have caught our attention to explore the genetic relationship, especially life-threatening severe cutaneous adverse drug reactions (SCARs), including acute generalized exanthematous pustulosis (AGEP), drug reactions with eosinophilia and systemic symptoms (DRESS), Stevens–Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). In recent years, many studies have investigated the immune mechanism and genetic markers of DHRs. Besides, several studies have stated the associations between antibiotics-as well as anti-osteoporotic drugs (AOD)-induced SCARs and specific human leukocyte antigens (HLA) alleles. Strong associations between drugs and HLA alleles such as co-trimoxazole-induced DRESS and HLA-B*13:01 (Odds ratio (OR) = 45), dapsone-DRESS and HLA-B*13:01 (OR = 122.1), vancomycin-DRESS and HLA-A*32:01 (OR = 403), clindamycin-DHRs and HLA-B*15:27 (OR = 55.6), and strontium ranelate (SR)-SJS/TEN and HLA-A*33:03 (OR = 25.97) are listed. We summarized the immune mechanism of SCARs, update the latest knowledge of pharmacogenomics of antibiotics- and AOD-induced SCARs, and indicate the potential clinical use of these genetic markers for SCARs prevention in this mini review article.https://www.frontiersin.org/articles/10.3389/fphar.2023.1183491/fulldelayed hypersensitivity reactionshuman leukocyte antigensStevens-Johnson syndrometoxic epidermal necrosisdrug reactions with eosinophilia and systemic symptoms |
| spellingShingle | Chih-Hsuan Wung Chuang-Wei Wang Chuang-Wei Wang Chuang-Wei Wang Chuang-Wei Wang Kuo-Chu Lai Kuo-Chu Lai Kuo-Chu Lai Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Wei-Ti Chen Wei-Ti Chen Wei-Ti Chen Shuen-Iu Hung Shuen-Iu Hung Shuen-Iu Hung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Taiwan Severe Cutaneous Adverse Reaction Consortium Current understanding of genetic associations with delayed hypersensitivity reactions induced by antibiotics and anti-osteoporotic drugs Frontiers in Pharmacology delayed hypersensitivity reactions human leukocyte antigens Stevens-Johnson syndrome toxic epidermal necrosis drug reactions with eosinophilia and systemic symptoms |
| title | Current understanding of genetic associations with delayed hypersensitivity reactions induced by antibiotics and anti-osteoporotic drugs |
| title_full | Current understanding of genetic associations with delayed hypersensitivity reactions induced by antibiotics and anti-osteoporotic drugs |
| title_fullStr | Current understanding of genetic associations with delayed hypersensitivity reactions induced by antibiotics and anti-osteoporotic drugs |
| title_full_unstemmed | Current understanding of genetic associations with delayed hypersensitivity reactions induced by antibiotics and anti-osteoporotic drugs |
| title_short | Current understanding of genetic associations with delayed hypersensitivity reactions induced by antibiotics and anti-osteoporotic drugs |
| title_sort | current understanding of genetic associations with delayed hypersensitivity reactions induced by antibiotics and anti osteoporotic drugs |
| topic | delayed hypersensitivity reactions human leukocyte antigens Stevens-Johnson syndrome toxic epidermal necrosis drug reactions with eosinophilia and systemic symptoms |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1183491/full |
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