TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease
A hallmark of celiac disease is the gluten-dependent production of antibodies specific for deamidated gluten peptides (DGP) and the enzyme transglutaminase 2 (TG2). Both types of antibodies are believed to result from B cells receiving help from gluten-specific CD4+ T cells and differentiating into...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565743/?tool=EBI |
| _version_ | 1818918297804996608 |
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| author | Christian B. Lindstad Alisa E. Dewan Jorunn Stamnaes Ludvig M. Sollid M. Fleur du Pré |
| author_facet | Christian B. Lindstad Alisa E. Dewan Jorunn Stamnaes Ludvig M. Sollid M. Fleur du Pré |
| author_sort | Christian B. Lindstad |
| collection | DOAJ |
| description | A hallmark of celiac disease is the gluten-dependent production of antibodies specific for deamidated gluten peptides (DGP) and the enzyme transglutaminase 2 (TG2). Both types of antibodies are believed to result from B cells receiving help from gluten-specific CD4+ T cells and differentiating into antibody-producing plasma cells. We have here studied the collaboration between DGP- and TG2-specific B cells with gluten-specific CD4+ T cells using transgenic mice expressing celiac patient-derived T-cell and B-cell receptors, as well as between B-cell transfectants and patient-derived gluten-specific T-cell clones. We show that multivalent TG2-gluten complexes are efficient antigens for both TG2-specific and DGP-specific B cells and allow both types of B cells to receive help from gluten-specific T cells of many different specificities. |
| first_indexed | 2024-12-20T00:47:44Z |
| format | Article |
| id | doaj.art-fa939a27166143e9a3304aef314a1786 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T00:47:44Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-fa939a27166143e9a3304aef314a17862022-12-21T19:59:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011611TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac diseaseChristian B. LindstadAlisa E. DewanJorunn StamnaesLudvig M. SollidM. Fleur du PréA hallmark of celiac disease is the gluten-dependent production of antibodies specific for deamidated gluten peptides (DGP) and the enzyme transglutaminase 2 (TG2). Both types of antibodies are believed to result from B cells receiving help from gluten-specific CD4+ T cells and differentiating into antibody-producing plasma cells. We have here studied the collaboration between DGP- and TG2-specific B cells with gluten-specific CD4+ T cells using transgenic mice expressing celiac patient-derived T-cell and B-cell receptors, as well as between B-cell transfectants and patient-derived gluten-specific T-cell clones. We show that multivalent TG2-gluten complexes are efficient antigens for both TG2-specific and DGP-specific B cells and allow both types of B cells to receive help from gluten-specific T cells of many different specificities.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565743/?tool=EBI |
| spellingShingle | Christian B. Lindstad Alisa E. Dewan Jorunn Stamnaes Ludvig M. Sollid M. Fleur du Pré TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease PLoS ONE |
| title | TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease |
| title_full | TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease |
| title_fullStr | TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease |
| title_full_unstemmed | TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease |
| title_short | TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease |
| title_sort | tg2 gluten complexes as antigens for gluten specific and transglutaminase 2 specific b cells in celiac disease |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565743/?tool=EBI |
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