A retrospective drug use evaluation of cabergoline for lactation inhibition at a tertiary care teaching hospital in Qatar
Doua AlSaad,1 Samah ElSalem,1 Palli Valapila Abdulrouf,1 Binny Thomas,1,2 Tayseer Alsaad,3 Afif Ahmed,1 Moza AlHail4 1Department of Pharmacy, Women’s Hospital, Hamad Medical Corporation, Doha, Qatar; 2Department of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, UK; 3Depar...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-02-01
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| Series: | Therapeutics and Clinical Risk Management |
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| Online Access: | https://www.dovepress.com/a-retrospective-drug-use-evaluation-of-cabergoline-for-lactation-inhib-peer-reviewed-article-TCRM |
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| author | AlSaad D ElSalem S Abdulrouf PV Thomas B Alsaad T Ahmad A AlHail M |
| author_facet | AlSaad D ElSalem S Abdulrouf PV Thomas B Alsaad T Ahmad A AlHail M |
| author_sort | AlSaad D |
| collection | DOAJ |
| description | Doua AlSaad,1 Samah ElSalem,1 Palli Valapila Abdulrouf,1 Binny Thomas,1,2 Tayseer Alsaad,3 Afif Ahmed,1 Moza AlHail4 1Department of Pharmacy, Women’s Hospital, Hamad Medical Corporation, Doha, Qatar; 2Department of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, UK; 3Department of Pediatrics, Hamad General Hospital, 4Clinical Support Service Unit, Hamad Medical Corporation, Doha, Qatar Background: Breastfeeding is considered as gold standard for infant nutrition and should be interrupted only when a compelling indication exists. Certain medical conditions such as abortion, stillbirth, HIV infection, or infant galactosemia and certain medications such as chemotherapy necessitate lactation inhibition to protect the health of mother and infant. Drug use evaluation (DUE) studies are done to explore the current practice in a setting and help to identify areas in which further information and education may be needed by clinicians.Objective: The aim of this study was to conduct a DUE of cabergoline to assess indications for lactation inhibition, dosage regimen, and its safety.Method: A retrospective cross-sectional DUE study was conducted over a period of 4 months from September 1, 2013, till December 31, 2013, at the Women’s Hospital, Qatar. All cabergoline prescriptions written for lactation inhibition within 10 days of delivery or abortion were included in the study. A descriptive data analysis was undertaken.Results: Of the 85 patients included, stillbirth (50.6%) was considered as the main reason for lactation inhibition, followed by abortion (27.1%) and neonatal death (12.9%). The remaining 9.4% of the patients had live baby, and the majority of them were prescribed cabergoline for lactation inhibition because their maternal medical conditions required the use of drugs with insufficient safety data (n=6). Seventy-four percent of patients received cabergoline at accurate time and dose. However, 14% of the patients had preexisting hypertensive disorder and 58.3% of them were diagnosed as uncontrolled hypertension.Conclusion: The current DUE study found that cabergoline was mainly used to inhibit lactation for patients with stillbirth, abortion, and neonatal death. In mothers who use medications for other medical conditions, benefits and risks of breastfeeding should be carefully balanced before prescribing cabergoline. Current prescribing pattern can be further enhanced through informing health care providers regarding appropriate cabergoline dosage regimen and its safety in patients with uncontrolled hypertension. Keywords: lactation inhibition, cabergoline, drug use evaluation, breastfeeding inhibition |
| first_indexed | 2024-12-17T19:24:02Z |
| format | Article |
| id | doaj.art-fa945b925f674b34a373be9a027850d5 |
| institution | Directory Open Access Journal |
| issn | 1178-203X |
| language | English |
| last_indexed | 2024-12-17T19:24:02Z |
| publishDate | 2016-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Therapeutics and Clinical Risk Management |
| spelling | doaj.art-fa945b925f674b34a373be9a027850d52022-12-21T21:35:26ZengDove Medical PressTherapeutics and Clinical Risk Management1178-203X2016-02-012016Issue 115516025525A retrospective drug use evaluation of cabergoline for lactation inhibition at a tertiary care teaching hospital in QatarAlSaad DElSalem SAbdulrouf PVThomas BAlsaad TAhmad AAlHail MDoua AlSaad,1 Samah ElSalem,1 Palli Valapila Abdulrouf,1 Binny Thomas,1,2 Tayseer Alsaad,3 Afif Ahmed,1 Moza AlHail4 1Department of Pharmacy, Women’s Hospital, Hamad Medical Corporation, Doha, Qatar; 2Department of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, UK; 3Department of Pediatrics, Hamad General Hospital, 4Clinical Support Service Unit, Hamad Medical Corporation, Doha, Qatar Background: Breastfeeding is considered as gold standard for infant nutrition and should be interrupted only when a compelling indication exists. Certain medical conditions such as abortion, stillbirth, HIV infection, or infant galactosemia and certain medications such as chemotherapy necessitate lactation inhibition to protect the health of mother and infant. Drug use evaluation (DUE) studies are done to explore the current practice in a setting and help to identify areas in which further information and education may be needed by clinicians.Objective: The aim of this study was to conduct a DUE of cabergoline to assess indications for lactation inhibition, dosage regimen, and its safety.Method: A retrospective cross-sectional DUE study was conducted over a period of 4 months from September 1, 2013, till December 31, 2013, at the Women’s Hospital, Qatar. All cabergoline prescriptions written for lactation inhibition within 10 days of delivery or abortion were included in the study. A descriptive data analysis was undertaken.Results: Of the 85 patients included, stillbirth (50.6%) was considered as the main reason for lactation inhibition, followed by abortion (27.1%) and neonatal death (12.9%). The remaining 9.4% of the patients had live baby, and the majority of them were prescribed cabergoline for lactation inhibition because their maternal medical conditions required the use of drugs with insufficient safety data (n=6). Seventy-four percent of patients received cabergoline at accurate time and dose. However, 14% of the patients had preexisting hypertensive disorder and 58.3% of them were diagnosed as uncontrolled hypertension.Conclusion: The current DUE study found that cabergoline was mainly used to inhibit lactation for patients with stillbirth, abortion, and neonatal death. In mothers who use medications for other medical conditions, benefits and risks of breastfeeding should be carefully balanced before prescribing cabergoline. Current prescribing pattern can be further enhanced through informing health care providers regarding appropriate cabergoline dosage regimen and its safety in patients with uncontrolled hypertension. Keywords: lactation inhibition, cabergoline, drug use evaluation, breastfeeding inhibitionhttps://www.dovepress.com/a-retrospective-drug-use-evaluation-of-cabergoline-for-lactation-inhib-peer-reviewed-article-TCRMLactation inhibitioncabergolinedrug use evaluation |
| spellingShingle | AlSaad D ElSalem S Abdulrouf PV Thomas B Alsaad T Ahmad A AlHail M A retrospective drug use evaluation of cabergoline for lactation inhibition at a tertiary care teaching hospital in Qatar Therapeutics and Clinical Risk Management Lactation inhibition cabergoline drug use evaluation |
| title | A retrospective drug use evaluation of cabergoline for lactation inhibition at a tertiary care teaching hospital in Qatar |
| title_full | A retrospective drug use evaluation of cabergoline for lactation inhibition at a tertiary care teaching hospital in Qatar |
| title_fullStr | A retrospective drug use evaluation of cabergoline for lactation inhibition at a tertiary care teaching hospital in Qatar |
| title_full_unstemmed | A retrospective drug use evaluation of cabergoline for lactation inhibition at a tertiary care teaching hospital in Qatar |
| title_short | A retrospective drug use evaluation of cabergoline for lactation inhibition at a tertiary care teaching hospital in Qatar |
| title_sort | retrospective drug use evaluation of cabergoline for lactation inhibition at a tertiary care teaching hospital in qatar |
| topic | Lactation inhibition cabergoline drug use evaluation |
| url | https://www.dovepress.com/a-retrospective-drug-use-evaluation-of-cabergoline-for-lactation-inhib-peer-reviewed-article-TCRM |
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