Au–ZnO Conjugated Black Phosphorus as a Near-Infrared Light-Triggering and Recurrence-Suppressing Nanoantibiotic Platform against <i>Staphylococcus aureus</i>
Antibiotic therapy is the gold standard for bacterial infections treatment. However, the rapid increase in multidrug-resistant (MDR) bacterial infections and its recent use for secondary bacterial infections in many COVID-19 patients has considerably weakened its treatment efficacy. These shortcomin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/1/52 |
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| author | Atanu Naskar Sohee Lee Kwang-sun Kim |
| author_facet | Atanu Naskar Sohee Lee Kwang-sun Kim |
| author_sort | Atanu Naskar |
| collection | DOAJ |
| description | Antibiotic therapy is the gold standard for bacterial infections treatment. However, the rapid increase in multidrug-resistant (MDR) bacterial infections and its recent use for secondary bacterial infections in many COVID-19 patients has considerably weakened its treatment efficacy. These shortcomings motivated researchers to develop new antibacterial materials, such as nanoparticle-based antibacterial platform with the ability to increase the chances of killing MDR strains and prevent their drug resistance. Herein, we report a new black phosphorus (BP)-based non-damaging near-infrared light-responsive platform conjugated with ZnO and Au nanoparticles as a synergistic antibacterial agent against <i>Staphylococcus aureus</i> species. First, BP nanosheets containing Au nanoparticles were assembled in situ with the ZnO nanoparticles prepared by a low-temperature solution synthesis method. Subsequently, the antibacterial activities of the resulting Au–ZnO–BP nanocomposite against the non-resistant, methicillin-resistant, and erythromycin-resistant <i>S. aureus</i> species were determined, after its photothermal efficacy was assessed. The synthesized nanocomposite exhibited excellent anti-<i>S. aureus</i> activity and good photothermal characteristics. The non-resistant <i>S. aureus</i> species did not produce drug-resistant bacteria after the treatment of multiple consecutive passages under the pressure of the proposed nanoantibiotic, but rapidly developed resistance to erythromycin. This work clearly demonstrates the excellent photothermal antibacterial properties of Au–ZnO–BP nanocomposite against the MDR <i>S. aureus</i> species. |
| first_indexed | 2024-03-10T13:32:30Z |
| format | Article |
| id | doaj.art-fa9502f1774447989110130c48d69a95 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T13:32:30Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-fa9502f1774447989110130c48d69a952023-11-21T07:48:15ZengMDPI AGPharmaceutics1999-49232021-01-011315210.3390/pharmaceutics13010052Au–ZnO Conjugated Black Phosphorus as a Near-Infrared Light-Triggering and Recurrence-Suppressing Nanoantibiotic Platform against <i>Staphylococcus aureus</i>Atanu Naskar0Sohee Lee1Kwang-sun Kim2Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, KoreaDepartment of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, KoreaDepartment of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, KoreaAntibiotic therapy is the gold standard for bacterial infections treatment. However, the rapid increase in multidrug-resistant (MDR) bacterial infections and its recent use for secondary bacterial infections in many COVID-19 patients has considerably weakened its treatment efficacy. These shortcomings motivated researchers to develop new antibacterial materials, such as nanoparticle-based antibacterial platform with the ability to increase the chances of killing MDR strains and prevent their drug resistance. Herein, we report a new black phosphorus (BP)-based non-damaging near-infrared light-responsive platform conjugated with ZnO and Au nanoparticles as a synergistic antibacterial agent against <i>Staphylococcus aureus</i> species. First, BP nanosheets containing Au nanoparticles were assembled in situ with the ZnO nanoparticles prepared by a low-temperature solution synthesis method. Subsequently, the antibacterial activities of the resulting Au–ZnO–BP nanocomposite against the non-resistant, methicillin-resistant, and erythromycin-resistant <i>S. aureus</i> species were determined, after its photothermal efficacy was assessed. The synthesized nanocomposite exhibited excellent anti-<i>S. aureus</i> activity and good photothermal characteristics. The non-resistant <i>S. aureus</i> species did not produce drug-resistant bacteria after the treatment of multiple consecutive passages under the pressure of the proposed nanoantibiotic, but rapidly developed resistance to erythromycin. This work clearly demonstrates the excellent photothermal antibacterial properties of Au–ZnO–BP nanocomposite against the MDR <i>S. aureus</i> species.https://www.mdpi.com/1999-4923/13/1/52low-temperature synthesisblack phosphorusantibacterial activityphotothermal therapydrug resistance |
| spellingShingle | Atanu Naskar Sohee Lee Kwang-sun Kim Au–ZnO Conjugated Black Phosphorus as a Near-Infrared Light-Triggering and Recurrence-Suppressing Nanoantibiotic Platform against <i>Staphylococcus aureus</i> Pharmaceutics low-temperature synthesis black phosphorus antibacterial activity photothermal therapy drug resistance |
| title | Au–ZnO Conjugated Black Phosphorus as a Near-Infrared Light-Triggering and Recurrence-Suppressing Nanoantibiotic Platform against <i>Staphylococcus aureus</i> |
| title_full | Au–ZnO Conjugated Black Phosphorus as a Near-Infrared Light-Triggering and Recurrence-Suppressing Nanoantibiotic Platform against <i>Staphylococcus aureus</i> |
| title_fullStr | Au–ZnO Conjugated Black Phosphorus as a Near-Infrared Light-Triggering and Recurrence-Suppressing Nanoantibiotic Platform against <i>Staphylococcus aureus</i> |
| title_full_unstemmed | Au–ZnO Conjugated Black Phosphorus as a Near-Infrared Light-Triggering and Recurrence-Suppressing Nanoantibiotic Platform against <i>Staphylococcus aureus</i> |
| title_short | Au–ZnO Conjugated Black Phosphorus as a Near-Infrared Light-Triggering and Recurrence-Suppressing Nanoantibiotic Platform against <i>Staphylococcus aureus</i> |
| title_sort | au zno conjugated black phosphorus as a near infrared light triggering and recurrence suppressing nanoantibiotic platform against i staphylococcus aureus i |
| topic | low-temperature synthesis black phosphorus antibacterial activity photothermal therapy drug resistance |
| url | https://www.mdpi.com/1999-4923/13/1/52 |
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