The Effect of Erythropoietin and Its Derivatives on Ischemic Stroke Therapy: A Comprehensive Review
Numerous studies explored the therapeutic effects of erythropoietin (EPO) on neurodegenerative diseases. Few studies provided comprehensive and latest knowledge of EPO treatment for ischemic stroke. In the present review, we introduced the structure, expression, function of EPO, and its receptors in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.743926/full |
| _version_ | 1828852987520352256 |
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| author | Yuanyuan Ma Zhiyuan Zhou Guo-Yuan Yang Jing Ding Xin Wang Xin Wang |
| author_facet | Yuanyuan Ma Zhiyuan Zhou Guo-Yuan Yang Jing Ding Xin Wang Xin Wang |
| author_sort | Yuanyuan Ma |
| collection | DOAJ |
| description | Numerous studies explored the therapeutic effects of erythropoietin (EPO) on neurodegenerative diseases. Few studies provided comprehensive and latest knowledge of EPO treatment for ischemic stroke. In the present review, we introduced the structure, expression, function of EPO, and its receptors in the central nervous system. Furthermore, we comprehensively discussed EPO treatment in pre-clinical studies, clinical trials, and its therapeutic mechanisms including suppressing inflammation. Finally, advanced studies of the therapy of EPO derivatives in ischemic stroke were also discussed. We wish to provide valuable information on EPO and EPO derivatives’ treatment for ischemic stroke for basic researchers and clinicians to accelerate the process of their clinical applications. |
| first_indexed | 2024-12-13T00:04:48Z |
| format | Article |
| id | doaj.art-fa99c273e9994848ae549a2b2db69fd8 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-13T00:04:48Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-fa99c273e9994848ae549a2b2db69fd82022-12-22T00:06:19ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-02-011310.3389/fphar.2022.743926743926The Effect of Erythropoietin and Its Derivatives on Ischemic Stroke Therapy: A Comprehensive ReviewYuanyuan Ma0Zhiyuan Zhou1Guo-Yuan Yang2Jing Ding3Xin Wang4Xin Wang5Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurology, Zhongshan Hospital, Fudan University, Shanghai, ChinaMed-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Neurology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of The State Key Laboratory of Medical Neurobiology, The Institutes of Brain Science and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, ChinaNumerous studies explored the therapeutic effects of erythropoietin (EPO) on neurodegenerative diseases. Few studies provided comprehensive and latest knowledge of EPO treatment for ischemic stroke. In the present review, we introduced the structure, expression, function of EPO, and its receptors in the central nervous system. Furthermore, we comprehensively discussed EPO treatment in pre-clinical studies, clinical trials, and its therapeutic mechanisms including suppressing inflammation. Finally, advanced studies of the therapy of EPO derivatives in ischemic stroke were also discussed. We wish to provide valuable information on EPO and EPO derivatives’ treatment for ischemic stroke for basic researchers and clinicians to accelerate the process of their clinical applications.https://www.frontiersin.org/articles/10.3389/fphar.2022.743926/fullbrainderivativeserythropoietinischemiatherapy |
| spellingShingle | Yuanyuan Ma Zhiyuan Zhou Guo-Yuan Yang Jing Ding Xin Wang Xin Wang The Effect of Erythropoietin and Its Derivatives on Ischemic Stroke Therapy: A Comprehensive Review Frontiers in Pharmacology brain derivatives erythropoietin ischemia therapy |
| title | The Effect of Erythropoietin and Its Derivatives on Ischemic Stroke Therapy: A Comprehensive Review |
| title_full | The Effect of Erythropoietin and Its Derivatives on Ischemic Stroke Therapy: A Comprehensive Review |
| title_fullStr | The Effect of Erythropoietin and Its Derivatives on Ischemic Stroke Therapy: A Comprehensive Review |
| title_full_unstemmed | The Effect of Erythropoietin and Its Derivatives on Ischemic Stroke Therapy: A Comprehensive Review |
| title_short | The Effect of Erythropoietin and Its Derivatives on Ischemic Stroke Therapy: A Comprehensive Review |
| title_sort | effect of erythropoietin and its derivatives on ischemic stroke therapy a comprehensive review |
| topic | brain derivatives erythropoietin ischemia therapy |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.743926/full |
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