Is there any relationship between PSA and increased peripheral CD4+CD25highFOX3+ Treg in prostate cancer patients?
Introduction: The aims of this study were fi rst, to determine whether peripheral levels of CD4+CD25highFoxp3+ regulatory T cells (Treg) are elevated in Prostate Cancer (PCa) patients, and second, to determine the direct correlation between peripheral Treg and total serum Prostate Specifi c Antigen...
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| Format: | Article |
| Language: | English |
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University of Sarajevo
2011-09-01
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| Series: | Journal of Health Sciences |
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| Online Access: | https://www.jhsci.ba/ojs/index.php/jhsci/article/view/27 |
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| author | Yigit Akin Sadi Koksoy Selcuk Yucel Tibet Erdogru Mehmet Baykara |
| author_facet | Yigit Akin Sadi Koksoy Selcuk Yucel Tibet Erdogru Mehmet Baykara |
| author_sort | Yigit Akin |
| collection | DOAJ |
| description | Introduction: The aims of this study were fi rst, to determine whether peripheral levels of CD4+CD25highFoxp3+ regulatory T cells (Treg) are elevated in Prostate Cancer (PCa) patients, and second, to determine the direct
correlation between peripheral Treg and total serum Prostate Specifi c Antigen (PSA) levels in these patients.
Methods: Peripheral Blood Mononuclear Cells from 56 subjects undergoing diagnostic prostate biopsies (PSA ≥ 2.5 ng/ml) were analyzed for Treg numbers. The association between the peripheral Treg and serum PSA values was fi rst determined in the entire population, including people with no prostate pathology and PCa and Benign Prostate Hyperplasia (BPH) patients, and second, in nine PCa patients before and after curative prostatectomy.
Results: This project was performed in Akdeniz University immunology laboratory and urology out patient clinic from 2008 to 2010. Peripheral Treg frequencies were signifi cantly increased in PCa patients (n = 19, 3.23 ± 1.59) compared with BPH patients (n = 27, 1.66 ± 0.80) and healthy subjects (n = 10, 1.08 ± 0.43) (p < 0.01). The percentage of Treg in BPH patients was also signifi cantly higher than that of healthy subjects (p < 0.01). Importantly, the increase in BPH and PCa patients paralleled the elevation in total serum PSA levels, demonstrating a strong positive correlation (r = 0.75; p < 0.01).
Conclusion: These results demonstrate that peripheral Treg densities are correlated with PSA in BPH and PCa patients, suggesting that PSA may have a role in Treg induction and/or maintenance in Treg in these people. |
| first_indexed | 2024-04-12T15:55:39Z |
| format | Article |
| id | doaj.art-fa9b5b0a74f94ef28c47ef68c63f1b10 |
| institution | Directory Open Access Journal |
| issn | 2232-7576 1986-8049 |
| language | English |
| last_indexed | 2024-04-12T15:55:39Z |
| publishDate | 2011-09-01 |
| publisher | University of Sarajevo |
| record_format | Article |
| series | Journal of Health Sciences |
| spelling | doaj.art-fa9b5b0a74f94ef28c47ef68c63f1b102022-12-22T03:26:22ZengUniversity of SarajevoJournal of Health Sciences2232-75761986-80492011-09-011210.17532/jhsci.2011.10427Is there any relationship between PSA and increased peripheral CD4+CD25highFOX3+ Treg in prostate cancer patients?Yigit Akin0Sadi Koksoy1Selcuk Yucel2Tibet Erdogru3Mehmet Baykara4Department of Urology, School of Medicine, Akdeniz University, Dumlupinar Bul. Kampus Tip fak. 07070, Antalya, Turkey.Department of Medical Microbiology, Akdeniz University, Dumlupinar Bul. Kampus Tip fak. 07070, Antalya, TurkeyDepartment of Urology, School of Medicine, Akdeniz University, Dumlupinar Bul. Kampus Tip fak. 07070, Antalya, Turkey.Department of Urology, School of Medicine, Akdeniz University, Dumlupinar Bul. Kampus Tip fak. 07070, Antalya, Turkey.Department of Urology, School of Medicine, Akdeniz University, Dumlupinar Bul. Kampus Tip fak. 07070, Antalya, Turkey.Introduction: The aims of this study were fi rst, to determine whether peripheral levels of CD4+CD25highFoxp3+ regulatory T cells (Treg) are elevated in Prostate Cancer (PCa) patients, and second, to determine the direct correlation between peripheral Treg and total serum Prostate Specifi c Antigen (PSA) levels in these patients. Methods: Peripheral Blood Mononuclear Cells from 56 subjects undergoing diagnostic prostate biopsies (PSA ≥ 2.5 ng/ml) were analyzed for Treg numbers. The association between the peripheral Treg and serum PSA values was fi rst determined in the entire population, including people with no prostate pathology and PCa and Benign Prostate Hyperplasia (BPH) patients, and second, in nine PCa patients before and after curative prostatectomy. Results: This project was performed in Akdeniz University immunology laboratory and urology out patient clinic from 2008 to 2010. Peripheral Treg frequencies were signifi cantly increased in PCa patients (n = 19, 3.23 ± 1.59) compared with BPH patients (n = 27, 1.66 ± 0.80) and healthy subjects (n = 10, 1.08 ± 0.43) (p < 0.01). The percentage of Treg in BPH patients was also signifi cantly higher than that of healthy subjects (p < 0.01). Importantly, the increase in BPH and PCa patients paralleled the elevation in total serum PSA levels, demonstrating a strong positive correlation (r = 0.75; p < 0.01). Conclusion: These results demonstrate that peripheral Treg densities are correlated with PSA in BPH and PCa patients, suggesting that PSA may have a role in Treg induction and/or maintenance in Treg in these people.https://www.jhsci.ba/ojs/index.php/jhsci/article/view/27CD4 CD25highFoxp3 Regulatory T cells (Treg)prostate cancerbenign prostate hyperplasiaPSATAA |
| spellingShingle | Yigit Akin Sadi Koksoy Selcuk Yucel Tibet Erdogru Mehmet Baykara Is there any relationship between PSA and increased peripheral CD4+CD25highFOX3+ Treg in prostate cancer patients? Journal of Health Sciences CD4 CD25highFoxp3 Regulatory T cells (Treg) prostate cancer benign prostate hyperplasia PSA TAA |
| title | Is there any relationship between PSA and increased peripheral CD4+CD25highFOX3+ Treg in prostate cancer patients? |
| title_full | Is there any relationship between PSA and increased peripheral CD4+CD25highFOX3+ Treg in prostate cancer patients? |
| title_fullStr | Is there any relationship between PSA and increased peripheral CD4+CD25highFOX3+ Treg in prostate cancer patients? |
| title_full_unstemmed | Is there any relationship between PSA and increased peripheral CD4+CD25highFOX3+ Treg in prostate cancer patients? |
| title_short | Is there any relationship between PSA and increased peripheral CD4+CD25highFOX3+ Treg in prostate cancer patients? |
| title_sort | is there any relationship between psa and increased peripheral cd4 cd25highfox3 treg in prostate cancer patients |
| topic | CD4 CD25highFoxp3 Regulatory T cells (Treg) prostate cancer benign prostate hyperplasia PSA TAA |
| url | https://www.jhsci.ba/ojs/index.php/jhsci/article/view/27 |
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