Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders
Human brain organoids cultured from human pluripotent stem cells provide a promising platform to recapitulate histological features of the human brain and model neural disorders. However, unlike animal models, brain organoids lack a reproducible topographic organization, which limits their applicati...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2020.00133/full |
| _version_ | 1818684518154895360 |
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| author | Augustin Chen Augustin Chen Augustin Chen Zhenming Guo Zhenming Guo Zhenming Guo Lipao Fang Lipao Fang Lipao Fang Shan Bian Shan Bian |
| author_facet | Augustin Chen Augustin Chen Augustin Chen Zhenming Guo Zhenming Guo Zhenming Guo Lipao Fang Lipao Fang Lipao Fang Shan Bian Shan Bian |
| author_sort | Augustin Chen |
| collection | DOAJ |
| description | Human brain organoids cultured from human pluripotent stem cells provide a promising platform to recapitulate histological features of the human brain and model neural disorders. However, unlike animal models, brain organoids lack a reproducible topographic organization, which limits their application in modeling intricate biology, such as the interaction between different brain regions. To overcome these drawbacks, brain organoids have been pre-patterned into specific brain regions and fused to form an assembloid that represents reproducible models recapitulating more complex biological processes of human brain development and neurological diseases. This approach has been applied to model interneuron migration, neuronal projections, tumor invasion, oligodendrogenesis, forebrain axis establishment, and brain vascularization. In this review article, we will summarize the usage of this technology to understand the fundamental biology underpinning human brain development and disorders. |
| first_indexed | 2024-12-17T10:51:54Z |
| format | Article |
| id | doaj.art-fa9c1a996f6a4293adedbef5df16597c |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-17T10:51:54Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-fa9c1a996f6a4293adedbef5df16597c2022-12-21T21:51:58ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022020-05-011410.3389/fncel.2020.00133535239Application of Fused Organoid Models to Study Human Brain Development and Neural DisordersAugustin Chen0Augustin Chen1Augustin Chen2Zhenming Guo3Zhenming Guo4Zhenming Guo5Lipao Fang6Lipao Fang7Lipao Fang8Shan Bian9Shan Bian10Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, ChinaFrontier Science Center for Stem Cell Research, Tongji University, Shanghai, ChinaMolecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, Homburg, GermanyInstitute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, ChinaFrontier Science Center for Stem Cell Research, Tongji University, Shanghai, ChinaBio-X Institute, Shanghai Jiao Tong University, Shanghai, ChinaInstitute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, ChinaFrontier Science Center for Stem Cell Research, Tongji University, Shanghai, ChinaMolecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, Homburg, GermanyInstitute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, ChinaFrontier Science Center for Stem Cell Research, Tongji University, Shanghai, ChinaHuman brain organoids cultured from human pluripotent stem cells provide a promising platform to recapitulate histological features of the human brain and model neural disorders. However, unlike animal models, brain organoids lack a reproducible topographic organization, which limits their application in modeling intricate biology, such as the interaction between different brain regions. To overcome these drawbacks, brain organoids have been pre-patterned into specific brain regions and fused to form an assembloid that represents reproducible models recapitulating more complex biological processes of human brain development and neurological diseases. This approach has been applied to model interneuron migration, neuronal projections, tumor invasion, oligodendrogenesis, forebrain axis establishment, and brain vascularization. In this review article, we will summarize the usage of this technology to understand the fundamental biology underpinning human brain development and disorders.https://www.frontiersin.org/article/10.3389/fncel.2020.00133/fullbrain organoidfusion modelsstem cellsbrain developementneural disorder |
| spellingShingle | Augustin Chen Augustin Chen Augustin Chen Zhenming Guo Zhenming Guo Zhenming Guo Lipao Fang Lipao Fang Lipao Fang Shan Bian Shan Bian Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders Frontiers in Cellular Neuroscience brain organoid fusion models stem cells brain developement neural disorder |
| title | Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders |
| title_full | Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders |
| title_fullStr | Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders |
| title_full_unstemmed | Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders |
| title_short | Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders |
| title_sort | application of fused organoid models to study human brain development and neural disorders |
| topic | brain organoid fusion models stem cells brain developement neural disorder |
| url | https://www.frontiersin.org/article/10.3389/fncel.2020.00133/full |
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