Micro- and Nanosized Carriers for Nose-to-Brain Drug Delivery in Neurodegenerative Disorders
Neurodegenerative disorders (NDs) have become a serious health problem worldwide due to the rapid increase in the number of people that are affected and the constantly aging population. Among all NDs, Alzheimer’s and Parkinson’s disease are the most common, and many efforts have been made in the dev...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/7/1706 |
| _version_ | 1797407342171521024 |
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| author | Radka Boyuklieva Bissera Pilicheva |
| author_facet | Radka Boyuklieva Bissera Pilicheva |
| author_sort | Radka Boyuklieva |
| collection | DOAJ |
| description | Neurodegenerative disorders (NDs) have become a serious health problem worldwide due to the rapid increase in the number of people that are affected and the constantly aging population. Among all NDs, Alzheimer’s and Parkinson’s disease are the most common, and many efforts have been made in the development of effective and reliable therapeutic strategies. The intranasal route of drug administration offers numerous advantages, such as bypassing the blood–brain barrier and providing a direct entrance to the brain through the olfactory and trigeminal neurons. The present review summarizes the available information on recent advances in micro- and nanoscale nose-to-brain drug-delivery systems as a novel strategy for the treatment of Alzheimer’s and Parkinson’s disease. Specifically, polymer- and lipid-base micro- and nanoparticles have been studied as a feasible approach to increase the brain bioavailability of certain drugs. Furthermore, nanocomposites are discussed as a suitable formulation for administration into the nasal cavity. |
| first_indexed | 2024-03-09T03:39:58Z |
| format | Article |
| id | doaj.art-fa9d3b14596742d98fb426cac7f66878 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T03:39:58Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-fa9d3b14596742d98fb426cac7f668782023-12-03T14:42:38ZengMDPI AGBiomedicines2227-90592022-07-01107170610.3390/biomedicines10071706Micro- and Nanosized Carriers for Nose-to-Brain Drug Delivery in Neurodegenerative DisordersRadka Boyuklieva0Bissera Pilicheva1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, BulgariaDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, BulgariaNeurodegenerative disorders (NDs) have become a serious health problem worldwide due to the rapid increase in the number of people that are affected and the constantly aging population. Among all NDs, Alzheimer’s and Parkinson’s disease are the most common, and many efforts have been made in the development of effective and reliable therapeutic strategies. The intranasal route of drug administration offers numerous advantages, such as bypassing the blood–brain barrier and providing a direct entrance to the brain through the olfactory and trigeminal neurons. The present review summarizes the available information on recent advances in micro- and nanoscale nose-to-brain drug-delivery systems as a novel strategy for the treatment of Alzheimer’s and Parkinson’s disease. Specifically, polymer- and lipid-base micro- and nanoparticles have been studied as a feasible approach to increase the brain bioavailability of certain drugs. Furthermore, nanocomposites are discussed as a suitable formulation for administration into the nasal cavity.https://www.mdpi.com/2227-9059/10/7/1706microparticlesnanoparticlesneurodegenerative disordersAlzheimer’s diseaseParkinson’s diseasenose-to-brain |
| spellingShingle | Radka Boyuklieva Bissera Pilicheva Micro- and Nanosized Carriers for Nose-to-Brain Drug Delivery in Neurodegenerative Disorders Biomedicines microparticles nanoparticles neurodegenerative disorders Alzheimer’s disease Parkinson’s disease nose-to-brain |
| title | Micro- and Nanosized Carriers for Nose-to-Brain Drug Delivery in Neurodegenerative Disorders |
| title_full | Micro- and Nanosized Carriers for Nose-to-Brain Drug Delivery in Neurodegenerative Disorders |
| title_fullStr | Micro- and Nanosized Carriers for Nose-to-Brain Drug Delivery in Neurodegenerative Disorders |
| title_full_unstemmed | Micro- and Nanosized Carriers for Nose-to-Brain Drug Delivery in Neurodegenerative Disorders |
| title_short | Micro- and Nanosized Carriers for Nose-to-Brain Drug Delivery in Neurodegenerative Disorders |
| title_sort | micro and nanosized carriers for nose to brain drug delivery in neurodegenerative disorders |
| topic | microparticles nanoparticles neurodegenerative disorders Alzheimer’s disease Parkinson’s disease nose-to-brain |
| url | https://www.mdpi.com/2227-9059/10/7/1706 |
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