N Terminal-Pro B Type Natriuretic Peptide (NT- PRO BNP) levels and severity of disease in elderly with heart failure
Background: Heart failure is a major health problem in the world. It is associated with high morbidity and high mortality especially in elderly patients. Most studies reported using N terminal pro-B type natriuretic peptide (NT-proBNP) in diagnosis of heart failure, but about of these tests in deter...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine
2020-12-01
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| Series: | JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) |
| Subjects: | |
| Online Access: | https://journal.uii.ac.id/JKKI/article/view/16510 |
| _version_ | 1827906241801748480 |
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| author | Erlina Marfianti Ana Fauziyati Barmawi Hisyam |
| author_facet | Erlina Marfianti Ana Fauziyati Barmawi Hisyam |
| author_sort | Erlina Marfianti |
| collection | DOAJ |
| description | Background: Heart failure is a major health problem in the world. It is associated with high morbidity and high mortality especially in elderly patients. Most studies reported using N terminal pro-B type natriuretic peptide (NT-proBNP) in diagnosis of heart failure, but about of these tests in determining classification of severity of heart failure in the elderly remain unclear.
Objective: To determine the differences NT-pro BNP levels based on the severity of diease of heart failure in elderly patients.
Methods: This is an observational study with cross sectional design. Subjects were patients with diagnosed heart failure and aged = 60 years. Patients were divided into two groups, mild and severe heart failure groups according to severity of heart failure in New York Heart Association (NYHA) class. The NT Pro-BNP levels were measured for all subjects in both groups. Data was analyzed with using unpaired t test and was considered significant if p <0.05.
Results: This study involved 24 subjects, consisting of 2 gorups, there were mild heart failure groups (NYHA class I-II) and groups of patients with severe heart failure (NYHA III-IV). The mean age of the subjects was 64.50 ± 4.65 years with a minimum age of 60 years and a maximum of 78 years. The NT pro-BNP levels in the severe heart failure group (1.2587.58 ± 574.85 pg / ml) was higher than the mild heart failure group (867.83 ± 333.27 pg / ml), it was statistically significant with p = 0.040.
Conclusion: The levels of NT-pro BNP serum in elderly patients with severe heart failure (NYHA III-IV) were significantly higher than in patients with mild heart failure (NYHA I-II). |
| first_indexed | 2024-03-13T00:53:45Z |
| format | Article |
| id | doaj.art-fa9e16835da74a84bec31778b7975c17 |
| institution | Directory Open Access Journal |
| issn | 2085-4145 2527-2950 |
| language | English |
| last_indexed | 2024-03-13T00:53:45Z |
| publishDate | 2020-12-01 |
| publisher | Faculty of Medicine |
| record_format | Article |
| series | JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) |
| spelling | doaj.art-fa9e16835da74a84bec31778b7975c172023-07-07T07:41:36ZengFaculty of MedicineJKKI (Jurnal Kedokteran dan Kesehatan Indonesia)2085-41452527-29502020-12-0127628310.20885/JKKI.Vol11.Iss3.art913143N Terminal-Pro B Type Natriuretic Peptide (NT- PRO BNP) levels and severity of disease in elderly with heart failureErlina Marfianti0Ana Fauziyati1Barmawi Hisyam2Department of Internal Medicine, Faculty of Medicine, Universitas Islam Indonesia, YogyakartaDepartment of Internal Medicine, Faculty of Medicine, Universitas Islam Indonesia, YogyakartaDepartment of Internal Medicine, Faculty of Medicine, Universitas Islam Indonesia, YogyakartaBackground: Heart failure is a major health problem in the world. It is associated with high morbidity and high mortality especially in elderly patients. Most studies reported using N terminal pro-B type natriuretic peptide (NT-proBNP) in diagnosis of heart failure, but about of these tests in determining classification of severity of heart failure in the elderly remain unclear. Objective: To determine the differences NT-pro BNP levels based on the severity of diease of heart failure in elderly patients. Methods: This is an observational study with cross sectional design. Subjects were patients with diagnosed heart failure and aged = 60 years. Patients were divided into two groups, mild and severe heart failure groups according to severity of heart failure in New York Heart Association (NYHA) class. The NT Pro-BNP levels were measured for all subjects in both groups. Data was analyzed with using unpaired t test and was considered significant if p <0.05. Results: This study involved 24 subjects, consisting of 2 gorups, there were mild heart failure groups (NYHA class I-II) and groups of patients with severe heart failure (NYHA III-IV). The mean age of the subjects was 64.50 ± 4.65 years with a minimum age of 60 years and a maximum of 78 years. The NT pro-BNP levels in the severe heart failure group (1.2587.58 ± 574.85 pg / ml) was higher than the mild heart failure group (867.83 ± 333.27 pg / ml), it was statistically significant with p = 0.040. Conclusion: The levels of NT-pro BNP serum in elderly patients with severe heart failure (NYHA III-IV) were significantly higher than in patients with mild heart failure (NYHA I-II).https://journal.uii.ac.id/JKKI/article/view/16510nt pro bnp levelsseverity of diseaseheart failureelderly |
| spellingShingle | Erlina Marfianti Ana Fauziyati Barmawi Hisyam N Terminal-Pro B Type Natriuretic Peptide (NT- PRO BNP) levels and severity of disease in elderly with heart failure JKKI (Jurnal Kedokteran dan Kesehatan Indonesia) nt pro bnp levels severity of disease heart failure elderly |
| title | N Terminal-Pro B Type Natriuretic Peptide (NT- PRO BNP) levels and severity of disease in elderly with heart failure |
| title_full | N Terminal-Pro B Type Natriuretic Peptide (NT- PRO BNP) levels and severity of disease in elderly with heart failure |
| title_fullStr | N Terminal-Pro B Type Natriuretic Peptide (NT- PRO BNP) levels and severity of disease in elderly with heart failure |
| title_full_unstemmed | N Terminal-Pro B Type Natriuretic Peptide (NT- PRO BNP) levels and severity of disease in elderly with heart failure |
| title_short | N Terminal-Pro B Type Natriuretic Peptide (NT- PRO BNP) levels and severity of disease in elderly with heart failure |
| title_sort | n terminal pro b type natriuretic peptide nt pro bnp levels and severity of disease in elderly with heart failure |
| topic | nt pro bnp levels severity of disease heart failure elderly |
| url | https://journal.uii.ac.id/JKKI/article/view/16510 |
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