O-GlcNAc Modification During Pregnancy: Focus on Placental Environment
Successful placentation is a key event for fetal development, which commences following embryo implantation into the uterine wall, eliciting decidualization, placentation, and remodeling of blood vessels to provide physiological exchange between embryo-fetus and mother. Several signaling pathways ar...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.01263/full |
| _version_ | 1818300631946887168 |
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| author | Victor Vitorino Lima Vanessa Dela Justina Rinaldo Rodrigues dos Passos Gustavo Tadeu Volpato Paula Cristina S. Souto Sebastian San Martin Fernanda Regina Giachini Fernanda Regina Giachini |
| author_facet | Victor Vitorino Lima Vanessa Dela Justina Rinaldo Rodrigues dos Passos Gustavo Tadeu Volpato Paula Cristina S. Souto Sebastian San Martin Fernanda Regina Giachini Fernanda Regina Giachini |
| author_sort | Victor Vitorino Lima |
| collection | DOAJ |
| description | Successful placentation is a key event for fetal development, which commences following embryo implantation into the uterine wall, eliciting decidualization, placentation, and remodeling of blood vessels to provide physiological exchange between embryo-fetus and mother. Several signaling pathways are recruited to modulate such important processes and specific proteins that regulate placental function are a target for the glycosylation with O-linked β-N-acetylglucosamine (O-GlcNAc), or O-GlcNAcylation. This is a reversible post-translational modification on nuclear and cytoplasmic proteins, mainly controlled by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). O-GlcNAcylation has been implicated as a modulator of proteins, both in physiological and pathological conditions and, more recently, O-GlcNAc has also been shown to be an important modulator in placental tissue. In this mini-review, the interplay between O-GlcNAcylation of proteins and placental function will be addressed, discussing the possible implications of this post-translational modification through placental development and pregnancy. |
| first_indexed | 2024-12-13T05:10:12Z |
| format | Article |
| id | doaj.art-faa03ff9326747b6acddc78f6e30fb10 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-13T05:10:12Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-faa03ff9326747b6acddc78f6e30fb102022-12-21T23:58:34ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-09-01910.3389/fphys.2018.01263405784O-GlcNAc Modification During Pregnancy: Focus on Placental EnvironmentVictor Vitorino Lima0Vanessa Dela Justina1Rinaldo Rodrigues dos Passos2Gustavo Tadeu Volpato3Paula Cristina S. Souto4Sebastian San Martin5Fernanda Regina Giachini6Fernanda Regina Giachini7Institute of Health and Biological Science, Federal University of Mato Grosso, Barra do Garças, BrazilInstitute of Biological Science, Federal University of Goias, Goiânia, BrazilInstitute of Health and Biological Science, Federal University of Mato Grosso, Barra do Garças, BrazilInstitute of Health and Biological Science, Federal University of Mato Grosso, Barra do Garças, BrazilInstitute of Health and Biological Science, Federal University of Mato Grosso, Barra do Garças, BrazilBiomedical Research Center, School of Medicine, Universidad de Valparaíso, Valparaíso, ChileInstitute of Health and Biological Science, Federal University of Mato Grosso, Barra do Garças, BrazilInstitute of Biological Science, Federal University of Goias, Goiânia, BrazilSuccessful placentation is a key event for fetal development, which commences following embryo implantation into the uterine wall, eliciting decidualization, placentation, and remodeling of blood vessels to provide physiological exchange between embryo-fetus and mother. Several signaling pathways are recruited to modulate such important processes and specific proteins that regulate placental function are a target for the glycosylation with O-linked β-N-acetylglucosamine (O-GlcNAc), or O-GlcNAcylation. This is a reversible post-translational modification on nuclear and cytoplasmic proteins, mainly controlled by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). O-GlcNAcylation has been implicated as a modulator of proteins, both in physiological and pathological conditions and, more recently, O-GlcNAc has also been shown to be an important modulator in placental tissue. In this mini-review, the interplay between O-GlcNAcylation of proteins and placental function will be addressed, discussing the possible implications of this post-translational modification through placental development and pregnancy.https://www.frontiersin.org/article/10.3389/fphys.2018.01263/fullplacental dysfunctionO-GlcNAcpost-translational modificationpregnancyplacentation |
| spellingShingle | Victor Vitorino Lima Vanessa Dela Justina Rinaldo Rodrigues dos Passos Gustavo Tadeu Volpato Paula Cristina S. Souto Sebastian San Martin Fernanda Regina Giachini Fernanda Regina Giachini O-GlcNAc Modification During Pregnancy: Focus on Placental Environment Frontiers in Physiology placental dysfunction O-GlcNAc post-translational modification pregnancy placentation |
| title | O-GlcNAc Modification During Pregnancy: Focus on Placental Environment |
| title_full | O-GlcNAc Modification During Pregnancy: Focus on Placental Environment |
| title_fullStr | O-GlcNAc Modification During Pregnancy: Focus on Placental Environment |
| title_full_unstemmed | O-GlcNAc Modification During Pregnancy: Focus on Placental Environment |
| title_short | O-GlcNAc Modification During Pregnancy: Focus on Placental Environment |
| title_sort | o glcnac modification during pregnancy focus on placental environment |
| topic | placental dysfunction O-GlcNAc post-translational modification pregnancy placentation |
| url | https://www.frontiersin.org/article/10.3389/fphys.2018.01263/full |
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