Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia
Heme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide (CO) and iron into circulation. These byproducts of heme degradation can have potent cytoprotective effects in the face of stressors such as hypoxia and ischemia-reperfusion events. The potential for exogenous use o...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-07-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.00886/full |
| _version_ | 1818302303729352704 |
|---|---|
| author | Michael S. Tift Rodrigo W. Alves de Souza Janick Weber Erica C. Heinrich Francisco C. Villafuerte Atul Malhotra Leo E. Otterbein Tatum S. Simonson |
| author_facet | Michael S. Tift Rodrigo W. Alves de Souza Janick Weber Erica C. Heinrich Francisco C. Villafuerte Atul Malhotra Leo E. Otterbein Tatum S. Simonson |
| author_sort | Michael S. Tift |
| collection | DOAJ |
| description | Heme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide (CO) and iron into circulation. These byproducts of heme degradation can have potent cytoprotective effects in the face of stressors such as hypoxia and ischemia-reperfusion events. The potential for exogenous use of CO as a therapeutic agent has received increasing attention throughout the past few decades. Further, HO and CO are noted as putatively adaptive in diving mammals and certain high-altitude human populations that are frequently exposed to hypoxia and/or ischemia-reperfusion events, suggesting that HO and endogenous CO afford an evolutionary advantage for hypoxia tolerance and are critical in cell survival and injury avoidance. Our goal is to describe the importance of examining HO and CO in several systems, the physiological links, and the genetic factors that underlie variation in the HO/CO pathway. Finally, we emphasize the ways in which evolutionary perspectives may enhance our understanding of the HO/CO pathway in the context of diverse clinical settings. |
| first_indexed | 2024-12-13T05:36:46Z |
| format | Article |
| id | doaj.art-faa39b6162fa4b2c9ad35d48e6a632cf |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-13T05:36:46Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-faa39b6162fa4b2c9ad35d48e6a632cf2022-12-21T23:57:55ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-07-011110.3389/fphys.2020.00886554688Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During HypoxiaMichael S. Tift0Rodrigo W. Alves de Souza1Janick Weber2Erica C. Heinrich3Francisco C. Villafuerte4Atul Malhotra5Leo E. Otterbein6Tatum S. Simonson7Department of Biology and Marine Biology, University of North Carolina Wilmington, Wilmington, NC, United StatesDepartment of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United StatesDepartment of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United StatesDivision of Biomedical Sciences, University of California Riverside, School of Medicine, Riverside, CA, United StatesLaboratorio de Fisiología Comparada, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, PeruDivision of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, School of Medicine, San Diego, CA, United StatesDepartment of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United StatesDivision of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, School of Medicine, San Diego, CA, United StatesHeme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide (CO) and iron into circulation. These byproducts of heme degradation can have potent cytoprotective effects in the face of stressors such as hypoxia and ischemia-reperfusion events. The potential for exogenous use of CO as a therapeutic agent has received increasing attention throughout the past few decades. Further, HO and CO are noted as putatively adaptive in diving mammals and certain high-altitude human populations that are frequently exposed to hypoxia and/or ischemia-reperfusion events, suggesting that HO and endogenous CO afford an evolutionary advantage for hypoxia tolerance and are critical in cell survival and injury avoidance. Our goal is to describe the importance of examining HO and CO in several systems, the physiological links, and the genetic factors that underlie variation in the HO/CO pathway. Finally, we emphasize the ways in which evolutionary perspectives may enhance our understanding of the HO/CO pathway in the context of diverse clinical settings.https://www.frontiersin.org/article/10.3389/fphys.2020.00886/fullcarbon monoxideheme oxygenasehypoxiaaltitudedivingevolution |
| spellingShingle | Michael S. Tift Rodrigo W. Alves de Souza Janick Weber Erica C. Heinrich Francisco C. Villafuerte Atul Malhotra Leo E. Otterbein Tatum S. Simonson Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia Frontiers in Physiology carbon monoxide heme oxygenase hypoxia altitude diving evolution |
| title | Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia |
| title_full | Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia |
| title_fullStr | Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia |
| title_full_unstemmed | Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia |
| title_short | Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia |
| title_sort | adaptive potential of the heme oxygenase carbon monoxide pathway during hypoxia |
| topic | carbon monoxide heme oxygenase hypoxia altitude diving evolution |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.00886/full |
| work_keys_str_mv | AT michaelstift adaptivepotentialofthehemeoxygenasecarbonmonoxidepathwayduringhypoxia AT rodrigowalvesdesouza adaptivepotentialofthehemeoxygenasecarbonmonoxidepathwayduringhypoxia AT janickweber adaptivepotentialofthehemeoxygenasecarbonmonoxidepathwayduringhypoxia AT ericacheinrich adaptivepotentialofthehemeoxygenasecarbonmonoxidepathwayduringhypoxia AT franciscocvillafuerte adaptivepotentialofthehemeoxygenasecarbonmonoxidepathwayduringhypoxia AT atulmalhotra adaptivepotentialofthehemeoxygenasecarbonmonoxidepathwayduringhypoxia AT leoeotterbein adaptivepotentialofthehemeoxygenasecarbonmonoxidepathwayduringhypoxia AT tatumssimonson adaptivepotentialofthehemeoxygenasecarbonmonoxidepathwayduringhypoxia |