Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia

Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia

Heme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide (CO) and iron into circulation. These byproducts of heme degradation can have potent cytoprotective effects in the face of stressors such as hypoxia and ischemia-reperfusion events. The potential for exogenous use o...

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Bibliographic Details
Main Authors: Michael S. Tift, Rodrigo W. Alves de Souza, Janick Weber, Erica C. Heinrich, Francisco C. Villafuerte, Atul Malhotra, Leo E. Otterbein, Tatum S. Simonson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Physiology
Subjects:
carbon monoxide
heme oxygenase
hypoxia
altitude
diving
evolution
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00886/full

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