Association of maternal exposure to endocrine disruptor chemicals with cardio-metabolic risk factors in children during childhood: a systematic review and meta-analysis of cohort studies
Abstract Background In the present systematic review and meta-analysis, the association of maternal exposure to the endocrine disrupting chemicals (EDCs) with cardio-metabolic risk factors in children during childhood for the first time. Method The PubMed, Scopus, EMBASE, and Web of Science database...
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | https://doi.org/10.1186/s13098-024-01320-0 |
| _version_ | 1797219704418336768 |
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| author | Mehran Rahimlou Mir Ali Mousavi Hossein Chiti Mazyar Peyda Seyedeh Neda Mousavi |
| author_facet | Mehran Rahimlou Mir Ali Mousavi Hossein Chiti Mazyar Peyda Seyedeh Neda Mousavi |
| author_sort | Mehran Rahimlou |
| collection | DOAJ |
| description | Abstract Background In the present systematic review and meta-analysis, the association of maternal exposure to the endocrine disrupting chemicals (EDCs) with cardio-metabolic risk factors in children during childhood for the first time. Method The PubMed, Scopus, EMBASE, and Web of Science databases were systematically searched, up to Feb 2023. In total 30 cohort studies had our inclusion criteria. A random-effects model was used for the variables that had considerable heterogeneity between studies. The Newcastle–Ottawa Scale (NOS) tool was used to classify the quality score of studies. All statistical analyses were conducted using Stata 14 and P-value < 0.05 considered as a significant level. Results In the meta-analysis, maternal exposure to the EDCs was weakly associated with higher SBP (Fisher_Z: 0.06, CI: 0.04, 0.08), BMI (Fisher_Z: 0.07, CI: 0.06, 0.08), and WC (Fisher_Z: 0.06, CI: 0.03, 0.08) z-scores in children. A significant linear association was found between maternal exposure to the bisphenol-A and pesticides with BMI and WC z-score in children (p < 0.001). Subgroup analysis showed significant linear association of BPA and pesticides, in the urine samples of mothers at the first trimester of pregnancy, with BMI and WC z-score in children from 2–8 years (p < 0.05). Conclusion Prenatal exposure to the EDCs in the uterine period could increase the risk of obesity in children. Maternal exposure to bisphenol-A and pesticides showed the strongest association with the obesity, especially visceral form, in the next generation. |
| first_indexed | 2024-04-24T12:37:53Z |
| format | Article |
| id | doaj.art-faa58dd6eac548108244dfe558d55ff7 |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-04-24T12:37:53Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-faa58dd6eac548108244dfe558d55ff72024-04-07T11:25:56ZengBMCDiabetology & Metabolic Syndrome1758-59962024-04-0116111610.1186/s13098-024-01320-0Association of maternal exposure to endocrine disruptor chemicals with cardio-metabolic risk factors in children during childhood: a systematic review and meta-analysis of cohort studiesMehran Rahimlou0Mir Ali Mousavi1Hossein Chiti2Mazyar Peyda3Seyedeh Neda Mousavi4Department of Nutrition, School of Public Health, Zanjan University of Medical SciencesDepartment of General Surgery, Ayatollah Mousavi Hospital, Zanjan University of Medical SciencesZanjan Metabolic Diseases Research Center, Zanjan University of Medical SciencesDepartment of Environmental Health Engineering, School of Public Health, Zanjan University of Medical SciencesZanjan Metabolic Diseases Research Center, Zanjan University of Medical SciencesAbstract Background In the present systematic review and meta-analysis, the association of maternal exposure to the endocrine disrupting chemicals (EDCs) with cardio-metabolic risk factors in children during childhood for the first time. Method The PubMed, Scopus, EMBASE, and Web of Science databases were systematically searched, up to Feb 2023. In total 30 cohort studies had our inclusion criteria. A random-effects model was used for the variables that had considerable heterogeneity between studies. The Newcastle–Ottawa Scale (NOS) tool was used to classify the quality score of studies. All statistical analyses were conducted using Stata 14 and P-value < 0.05 considered as a significant level. Results In the meta-analysis, maternal exposure to the EDCs was weakly associated with higher SBP (Fisher_Z: 0.06, CI: 0.04, 0.08), BMI (Fisher_Z: 0.07, CI: 0.06, 0.08), and WC (Fisher_Z: 0.06, CI: 0.03, 0.08) z-scores in children. A significant linear association was found between maternal exposure to the bisphenol-A and pesticides with BMI and WC z-score in children (p < 0.001). Subgroup analysis showed significant linear association of BPA and pesticides, in the urine samples of mothers at the first trimester of pregnancy, with BMI and WC z-score in children from 2–8 years (p < 0.05). Conclusion Prenatal exposure to the EDCs in the uterine period could increase the risk of obesity in children. Maternal exposure to bisphenol-A and pesticides showed the strongest association with the obesity, especially visceral form, in the next generation.https://doi.org/10.1186/s13098-024-01320-0Metabolic disordersEndocrine disruptor chemicalsSystematic reviewMeta-analysis |
| spellingShingle | Mehran Rahimlou Mir Ali Mousavi Hossein Chiti Mazyar Peyda Seyedeh Neda Mousavi Association of maternal exposure to endocrine disruptor chemicals with cardio-metabolic risk factors in children during childhood: a systematic review and meta-analysis of cohort studies Diabetology & Metabolic Syndrome Metabolic disorders Endocrine disruptor chemicals Systematic review Meta-analysis |
| title | Association of maternal exposure to endocrine disruptor chemicals with cardio-metabolic risk factors in children during childhood: a systematic review and meta-analysis of cohort studies |
| title_full | Association of maternal exposure to endocrine disruptor chemicals with cardio-metabolic risk factors in children during childhood: a systematic review and meta-analysis of cohort studies |
| title_fullStr | Association of maternal exposure to endocrine disruptor chemicals with cardio-metabolic risk factors in children during childhood: a systematic review and meta-analysis of cohort studies |
| title_full_unstemmed | Association of maternal exposure to endocrine disruptor chemicals with cardio-metabolic risk factors in children during childhood: a systematic review and meta-analysis of cohort studies |
| title_short | Association of maternal exposure to endocrine disruptor chemicals with cardio-metabolic risk factors in children during childhood: a systematic review and meta-analysis of cohort studies |
| title_sort | association of maternal exposure to endocrine disruptor chemicals with cardio metabolic risk factors in children during childhood a systematic review and meta analysis of cohort studies |
| topic | Metabolic disorders Endocrine disruptor chemicals Systematic review Meta-analysis |
| url | https://doi.org/10.1186/s13098-024-01320-0 |
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