Neutrophilic dermatoses in a seronegative rheumatoid arthritis patient: A case report
Abstract Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by symmetric and destructive polyarthritis with a broad‐spectrum clinical manifestation of various organs. RND is an unusual distinctive manifestation of RA and typically develops in severe RA. This report aims to pr...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.5249 |
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| author | Amel Awad IbnIdris Rodwan Abdel Gaffar. A. Mohammed Mohammed Elmujtba Adam Essa Atif Elhadi Abdalla Babker Ali Mohamed Abdelsatir Elnour Mohammed Elagib |
| author_facet | Amel Awad IbnIdris Rodwan Abdel Gaffar. A. Mohammed Mohammed Elmujtba Adam Essa Atif Elhadi Abdalla Babker Ali Mohamed Abdelsatir Elnour Mohammed Elagib |
| author_sort | Amel Awad IbnIdris Rodwan |
| collection | DOAJ |
| description | Abstract Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by symmetric and destructive polyarthritis with a broad‐spectrum clinical manifestation of various organs. RND is an unusual distinctive manifestation of RA and typically develops in severe RA. This report aims to present an unusual and a rare neutrophilic skin condition, in a seronegative RA Sudanese patient. A 51‐year‐old woman was diagnosed with RA three years ago and a history of bilateral polyarthritis, presented with a skin rash involving her extremities and abdomen. Clinical examination of her skin revealed the presence of maculopapular lesions affecting the extensor surfaces of the lower extremities and the lower part of the abdomen with hyperpigmentation. Hand X‐ray demonstrated periarticular osteopenia, and laboratory and immunological studies that include C‐reactive protein, erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), anticitrullinated peptide antibodies (ACPAs), and antinuclear factor in addition to skin biopsy were all suggested a diagnosis of neutrophilic dermatosis. The patient received steroids for the skin lesion still no significant improvement was seen, and then, cyclosporin 100 mg was administrated twice/ day with close monitoring, and two weeks later marked improvement was shown. |
| first_indexed | 2024-12-13T13:50:25Z |
| format | Article |
| id | doaj.art-faa6e4857ece4284baf8b040d5957a1b |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-12-13T13:50:25Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-faa6e4857ece4284baf8b040d5957a1b2022-12-21T23:43:15ZengWileyClinical Case Reports2050-09042022-01-01101n/an/a10.1002/ccr3.5249Neutrophilic dermatoses in a seronegative rheumatoid arthritis patient: A case reportAmel Awad IbnIdris Rodwan0Abdel Gaffar. A. Mohammed1Mohammed Elmujtba Adam Essa2Atif Elhadi Abdalla Babker3Ali Mohamed Abdelsatir4Elnour Mohammed Elagib5Department of Rheumatology Sudan Medical Specialization Council Khartoum SudanRheumatology Department Security Forces Hospital Makkah Saudi ArabiaDepartment of Clinical Medicine Medical and Cancer Research Institute Nyala SudanFaculty of Medicine University of Gezira Wad Madani SudanDepartment of Histopathology Khartoum Histocentre Khartoum SudanDepartment of Rheumatology Omdurman Military Hospital Khartoum SudanAbstract Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by symmetric and destructive polyarthritis with a broad‐spectrum clinical manifestation of various organs. RND is an unusual distinctive manifestation of RA and typically develops in severe RA. This report aims to present an unusual and a rare neutrophilic skin condition, in a seronegative RA Sudanese patient. A 51‐year‐old woman was diagnosed with RA three years ago and a history of bilateral polyarthritis, presented with a skin rash involving her extremities and abdomen. Clinical examination of her skin revealed the presence of maculopapular lesions affecting the extensor surfaces of the lower extremities and the lower part of the abdomen with hyperpigmentation. Hand X‐ray demonstrated periarticular osteopenia, and laboratory and immunological studies that include C‐reactive protein, erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), anticitrullinated peptide antibodies (ACPAs), and antinuclear factor in addition to skin biopsy were all suggested a diagnosis of neutrophilic dermatosis. The patient received steroids for the skin lesion still no significant improvement was seen, and then, cyclosporin 100 mg was administrated twice/ day with close monitoring, and two weeks later marked improvement was shown.https://doi.org/10.1002/ccr3.5249cyclosporineRNDseronegative RAskin lesionssteroids |
| spellingShingle | Amel Awad IbnIdris Rodwan Abdel Gaffar. A. Mohammed Mohammed Elmujtba Adam Essa Atif Elhadi Abdalla Babker Ali Mohamed Abdelsatir Elnour Mohammed Elagib Neutrophilic dermatoses in a seronegative rheumatoid arthritis patient: A case report Clinical Case Reports cyclosporine RND seronegative RA skin lesions steroids |
| title | Neutrophilic dermatoses in a seronegative rheumatoid arthritis patient: A case report |
| title_full | Neutrophilic dermatoses in a seronegative rheumatoid arthritis patient: A case report |
| title_fullStr | Neutrophilic dermatoses in a seronegative rheumatoid arthritis patient: A case report |
| title_full_unstemmed | Neutrophilic dermatoses in a seronegative rheumatoid arthritis patient: A case report |
| title_short | Neutrophilic dermatoses in a seronegative rheumatoid arthritis patient: A case report |
| title_sort | neutrophilic dermatoses in a seronegative rheumatoid arthritis patient a case report |
| topic | cyclosporine RND seronegative RA skin lesions steroids |
| url | https://doi.org/10.1002/ccr3.5249 |
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