Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation
T cell activation is critically controlled by T cell receptor (TCR) signalling. Here the authors show, using live cell imaging, atomic force microscopy and modelling simulation, a prompt separation of TCR and CD45 that negatively correlates with TCR activation, supporting a refined kinetic segregati...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03127-w |
| _version_ | 1818750655527911424 |
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| author | Yair Razvag Yair Neve-Oz Julia Sajman Meital Reches Eilon Sherman |
| author_facet | Yair Razvag Yair Neve-Oz Julia Sajman Meital Reches Eilon Sherman |
| author_sort | Yair Razvag |
| collection | DOAJ |
| description | T cell activation is critically controlled by T cell receptor (TCR) signalling. Here the authors show, using live cell imaging, atomic force microscopy and modelling simulation, a prompt separation of TCR and CD45 that negatively correlates with TCR activation, supporting a refined kinetic segregation model of TCR signalling. |
| first_indexed | 2024-12-18T04:23:08Z |
| format | Article |
| id | doaj.art-faa9064c87e14a9ba2dcce63fc9bc33e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:23:08Z |
| publishDate | 2018-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-faa9064c87e14a9ba2dcce63fc9bc33e2022-12-21T21:21:10ZengNature PortfolioNature Communications2041-17232018-02-019111710.1038/s41467-018-03127-wNanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activationYair Razvag0Yair Neve-Oz1Julia Sajman2Meital Reches3Eilon Sherman4Racah Institute of Physics, The Hebrew UniversityRacah Institute of Physics, The Hebrew UniversityRacah Institute of Physics, The Hebrew UniversityInstitute of Chemistry, The Hebrew UniversityRacah Institute of Physics, The Hebrew UniversityT cell activation is critically controlled by T cell receptor (TCR) signalling. Here the authors show, using live cell imaging, atomic force microscopy and modelling simulation, a prompt separation of TCR and CD45 that negatively correlates with TCR activation, supporting a refined kinetic segregation model of TCR signalling.https://doi.org/10.1038/s41467-018-03127-w |
| spellingShingle | Yair Razvag Yair Neve-Oz Julia Sajman Meital Reches Eilon Sherman Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation Nature Communications |
| title | Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation |
| title_full | Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation |
| title_fullStr | Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation |
| title_full_unstemmed | Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation |
| title_short | Nanoscale kinetic segregation of TCR and CD45 in engaged microvilli facilitates early T cell activation |
| title_sort | nanoscale kinetic segregation of tcr and cd45 in engaged microvilli facilitates early t cell activation |
| url | https://doi.org/10.1038/s41467-018-03127-w |
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