Prolactin promotes proliferation of germinal center B cells, formation of plasma cells, and elevated levels of IgG3 anti-dsDNA autoantibodies

Prolactin promotes proliferation of germinal center B cells, formation of plasma cells, and elevated levels of IgG3 anti-dsDNA autoantibodies

Systemic lupus erythematosus (SLE) mainly affects females at reproductive age, which has been associated with hormones, such as prolactin (PRL). Different studies suggest that PRL exacerbates the clinical manifestations of SLE both in patients and in mouse models (e.g., the MRL/lpr strain), increasi...

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Main Authors: Ricardo Carreón-Talavera, Paola Santana-Sánchez, Ezequiel Moisés Fuentes-Pananá, María Victoria Legorreta-Haquet, Luis Chávez-Sánchez, Patricia Sofia Gorocica-Rosete, Adriana Karina Chávez-Rueda
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
prolactin
systemic lupus erythematosus
B cells
germinal center
STAT1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1017115/full

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