Homotypic and heterotypic adhesion induced by odorant receptors and the β2-adrenergic receptor.
In the mouse olfactory system regulated expression of a large family of G Protein-Coupled Receptors (GPCRs), the Odorant Receptors (ORs), provides each sensory neuron with a single OR identity. In the wiring of the olfactory sensory neuron projections, a complex axon sorting process ensures the segr...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3846556?pdf=render |
| _version_ | 1818856880250814464 |
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| author | Marion Richard Sophie Jamet Coralie Fouquet Caroline Dubacq Nicole Boggetto Frédéric Pincet Christine Gourier Alain Trembleau |
| author_facet | Marion Richard Sophie Jamet Coralie Fouquet Caroline Dubacq Nicole Boggetto Frédéric Pincet Christine Gourier Alain Trembleau |
| author_sort | Marion Richard |
| collection | DOAJ |
| description | In the mouse olfactory system regulated expression of a large family of G Protein-Coupled Receptors (GPCRs), the Odorant Receptors (ORs), provides each sensory neuron with a single OR identity. In the wiring of the olfactory sensory neuron projections, a complex axon sorting process ensures the segregation of >1,000 subpopulations of axons of the same OR identity into homogeneously innervated glomeruli. ORs are critical determinants in axon sorting, and their presence on olfactory axons raises the intriguing possibility that they may participate in axonal wiring through direct or indirect trans-interactions mediating adhesion or repulsion between axons. In the present work, we used a biophysical assay to test the capacity of ORs to induce adhesion of cell doublets overexpressing these receptors. We also tested the β2 Adrenergic Receptor, a non-OR GPCR known to recapitulate the functions of ORs in olfactory axon sorting. We report here the first evidence for homo- and heterotypic adhesion between cells overexpressing the ORs MOR256-17 or M71, supporting the hypothesis that ORs may contribute to olfactory axon sorting by mediating differential adhesion between axons. |
| first_indexed | 2024-12-19T08:31:31Z |
| format | Article |
| id | doaj.art-fab0953eec28450088f2f38e5816d641 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T08:31:31Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-fab0953eec28450088f2f38e5816d6412022-12-21T20:29:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8010010.1371/journal.pone.0080100Homotypic and heterotypic adhesion induced by odorant receptors and the β2-adrenergic receptor.Marion RichardSophie JametCoralie FouquetCaroline DubacqNicole BoggettoFrédéric PincetChristine GourierAlain TrembleauIn the mouse olfactory system regulated expression of a large family of G Protein-Coupled Receptors (GPCRs), the Odorant Receptors (ORs), provides each sensory neuron with a single OR identity. In the wiring of the olfactory sensory neuron projections, a complex axon sorting process ensures the segregation of >1,000 subpopulations of axons of the same OR identity into homogeneously innervated glomeruli. ORs are critical determinants in axon sorting, and their presence on olfactory axons raises the intriguing possibility that they may participate in axonal wiring through direct or indirect trans-interactions mediating adhesion or repulsion between axons. In the present work, we used a biophysical assay to test the capacity of ORs to induce adhesion of cell doublets overexpressing these receptors. We also tested the β2 Adrenergic Receptor, a non-OR GPCR known to recapitulate the functions of ORs in olfactory axon sorting. We report here the first evidence for homo- and heterotypic adhesion between cells overexpressing the ORs MOR256-17 or M71, supporting the hypothesis that ORs may contribute to olfactory axon sorting by mediating differential adhesion between axons.http://europepmc.org/articles/PMC3846556?pdf=render |
| spellingShingle | Marion Richard Sophie Jamet Coralie Fouquet Caroline Dubacq Nicole Boggetto Frédéric Pincet Christine Gourier Alain Trembleau Homotypic and heterotypic adhesion induced by odorant receptors and the β2-adrenergic receptor. PLoS ONE |
| title | Homotypic and heterotypic adhesion induced by odorant receptors and the β2-adrenergic receptor. |
| title_full | Homotypic and heterotypic adhesion induced by odorant receptors and the β2-adrenergic receptor. |
| title_fullStr | Homotypic and heterotypic adhesion induced by odorant receptors and the β2-adrenergic receptor. |
| title_full_unstemmed | Homotypic and heterotypic adhesion induced by odorant receptors and the β2-adrenergic receptor. |
| title_short | Homotypic and heterotypic adhesion induced by odorant receptors and the β2-adrenergic receptor. |
| title_sort | homotypic and heterotypic adhesion induced by odorant receptors and the β2 adrenergic receptor |
| url | http://europepmc.org/articles/PMC3846556?pdf=render |
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