Predictive ability of Framingham risk score in Indian population - A retrospective study in a tertiary care hospital in patients with first acute coronary syndrome
Background: Framingham risk score (FRS) is a widely recognized tool used by clinicians worldwide to determine and estimate the 10-year risk of manifesting clinical cardiovascular disease (CVD) of an individual and classify them into different risk categories on the basis of which necessary intervent...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2022-08-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/45309 |
| _version_ | 1818506239900909568 |
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| author | Soumyasil Das Linkon Biswas Tathagata Mukherjee Koustav Biswas Subrata Kumar Pal |
| author_facet | Soumyasil Das Linkon Biswas Tathagata Mukherjee Koustav Biswas Subrata Kumar Pal |
| author_sort | Soumyasil Das |
| collection | DOAJ |
| description | Background: Framingham risk score (FRS) is a widely recognized tool used by clinicians worldwide to determine and estimate the 10-year risk of manifesting clinical cardiovascular disease (CVD) of an individual and classify them into different risk categories on the basis of which necessary intervention can be taken. However, there is certain evidence questioning its predictive ability for risk stratification among ethnic Indian and Asian population.
Aims and Objectives: In this study, we wanted to determine the predictive ability of FRS in the Indian population and to assess how the risk score is associated with certain variables which are not included in original FRS.
Materials and Methods: It was a single institutional, retrospective, and observational study in patients with evidence (by ECG or Cardiac biomarker test -Preferably Troponin T) of diagnosis of acute myocardial infarction for first time. Eligible patients were assessed for their previous clinical records to calculate risk score as per FSR-coronary heart disease 2002. Predictive ability of FRS and association with different risk factors was tested for statistical significance.
Results: The most of the study participants (63.8%) had low risk and only 4.8% of study population had high risk for developing CVD. Patients in the low risk group had significantly better high-density lipoprotein profile than other risk groups (P=0.001). Mean systolic blood pressure was significantly higher in high-risk population (155 vs. 131 vs. 138 mm of Hg; P=0.005). The left ventricular ejection fraction was significantly lower in high-risk group (39.2% vs. 53% vs. 52%, P=0.008). Serum creatinine level was also significantly higher in high-risk group (P=0.03).
Conclusion: This clearly showed underestimation of FRS in prediction of CVDs in our study. Perhaps FRS needs a calibration and modified form with inclusion of other risk factors and parameters to determine and predict the future risk of development of CVD more accurately in Indian population. |
| first_indexed | 2024-12-10T22:01:53Z |
| format | Article |
| id | doaj.art-fab16b2c0d444a2c9923d7f59697e7b9 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-12-10T22:01:53Z |
| publishDate | 2022-08-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-fab16b2c0d444a2c9923d7f59697e7b92022-12-22T01:31:53ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762022-08-01138133139https://doi.org/10.3126/ajms.v13i8.45309Predictive ability of Framingham risk score in Indian population - A retrospective study in a tertiary care hospital in patients with first acute coronary syndromeSoumyasil Das 0https://orcid.org/0000-0002-2461-7553Linkon Biswas 1https://orcid.org/0000-0003-0589-769XTathagata Mukherjee 2https://orcid.org/0000-0002-9905-8071Koustav Biswas 3https://orcid.org/0000-0002-8388-8628Subrata Kumar Pal 4https://orcid.org/0000-0001-6649-278XSenior Resident, Department of General Medicine, Malda Medical College and Hospital, West Bengal, India Senior Resident, Department of Radiotherapy, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India Senior Resident, Department of Nephrology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India Junior Resident, Department of Radiotherapy, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India Professor, Department of General Medicine, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal, India Background: Framingham risk score (FRS) is a widely recognized tool used by clinicians worldwide to determine and estimate the 10-year risk of manifesting clinical cardiovascular disease (CVD) of an individual and classify them into different risk categories on the basis of which necessary intervention can be taken. However, there is certain evidence questioning its predictive ability for risk stratification among ethnic Indian and Asian population. Aims and Objectives: In this study, we wanted to determine the predictive ability of FRS in the Indian population and to assess how the risk score is associated with certain variables which are not included in original FRS. Materials and Methods: It was a single institutional, retrospective, and observational study in patients with evidence (by ECG or Cardiac biomarker test -Preferably Troponin T) of diagnosis of acute myocardial infarction for first time. Eligible patients were assessed for their previous clinical records to calculate risk score as per FSR-coronary heart disease 2002. Predictive ability of FRS and association with different risk factors was tested for statistical significance. Results: The most of the study participants (63.8%) had low risk and only 4.8% of study population had high risk for developing CVD. Patients in the low risk group had significantly better high-density lipoprotein profile than other risk groups (P=0.001). Mean systolic blood pressure was significantly higher in high-risk population (155 vs. 131 vs. 138 mm of Hg; P=0.005). The left ventricular ejection fraction was significantly lower in high-risk group (39.2% vs. 53% vs. 52%, P=0.008). Serum creatinine level was also significantly higher in high-risk group (P=0.03). Conclusion: This clearly showed underestimation of FRS in prediction of CVDs in our study. Perhaps FRS needs a calibration and modified form with inclusion of other risk factors and parameters to determine and predict the future risk of development of CVD more accurately in Indian population.https://www.nepjol.info/index.php/AJMS/article/view/45309acute coronary syndrome; framingham risk score; indian population; predictive ability |
| spellingShingle | Soumyasil Das Linkon Biswas Tathagata Mukherjee Koustav Biswas Subrata Kumar Pal Predictive ability of Framingham risk score in Indian population - A retrospective study in a tertiary care hospital in patients with first acute coronary syndrome Asian Journal of Medical Sciences acute coronary syndrome; framingham risk score; indian population; predictive ability |
| title | Predictive ability of Framingham risk score in Indian population - A retrospective study in a tertiary care hospital in patients with first acute coronary syndrome |
| title_full | Predictive ability of Framingham risk score in Indian population - A retrospective study in a tertiary care hospital in patients with first acute coronary syndrome |
| title_fullStr | Predictive ability of Framingham risk score in Indian population - A retrospective study in a tertiary care hospital in patients with first acute coronary syndrome |
| title_full_unstemmed | Predictive ability of Framingham risk score in Indian population - A retrospective study in a tertiary care hospital in patients with first acute coronary syndrome |
| title_short | Predictive ability of Framingham risk score in Indian population - A retrospective study in a tertiary care hospital in patients with first acute coronary syndrome |
| title_sort | predictive ability of framingham risk score in indian population a retrospective study in a tertiary care hospital in patients with first acute coronary syndrome |
| topic | acute coronary syndrome; framingham risk score; indian population; predictive ability |
| url | https://www.nepjol.info/index.php/AJMS/article/view/45309 |
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