Crocins-rich tomato extracts showed enhanced protective effects in vitro
Crocins are high-value water soluble pigments that have long been recognized for their medicinal properties, and whose demand has increased worldwide in recent years. In the present study transgenic tomato fruits engineered for the production of crocins and hp3/Bsh tomato mutants with alterations in...
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Format: | Article |
Language: | English |
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Elsevier
2023-02-01
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Series: | Journal of Functional Foods |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623000324 |
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author | Lucía Morote María Lobato-Gómez Oussama Ahrazem Javier Argandoña Begoña Olmedilla-Alonso Alberto José López-Jiménez Gianfranco Diretto Rossana Cuciniello Paolo Bergamo Sarah Frusciante Enrique Niza Ángela Rubio-Moraga Stefania Crispi Antonio Granell Lourdes Gómez-Gómez |
author_facet | Lucía Morote María Lobato-Gómez Oussama Ahrazem Javier Argandoña Begoña Olmedilla-Alonso Alberto José López-Jiménez Gianfranco Diretto Rossana Cuciniello Paolo Bergamo Sarah Frusciante Enrique Niza Ángela Rubio-Moraga Stefania Crispi Antonio Granell Lourdes Gómez-Gómez |
author_sort | Lucía Morote |
collection | DOAJ |
description | Crocins are high-value water soluble pigments that have long been recognized for their medicinal properties, and whose demand has increased worldwide in recent years. In the present study transgenic tomato fruits engineered for the production of crocins and hp3/Bsh tomato mutants with alterations in the carotenoid metabolism, have been combined to increase the levels of crocins in tomato fruits. Tomato fruits from F4 plants showed high antioxidant capacity and the crocin-rich juice of the produced tomato fruit was protected neuroblastoma cells against oxidative insult, through its ability to activate factor 2 related to nuclear erythroid factor 2 (Nrf2). The bio-accessibility of crocins in the juice showed values similar to the ones observed with saffron. Overall, our results support that crocin-fortified tomatoes could result in higher crocin availability and have additional health-promoting effects and could provide better protection against oxidative stress related chronic diseases in humans. |
first_indexed | 2024-04-10T17:24:24Z |
format | Article |
id | doaj.art-fab2121bf5c240fa99838cc229d29b8a |
institution | Directory Open Access Journal |
issn | 1756-4646 |
language | English |
last_indexed | 2024-04-10T17:24:24Z |
publishDate | 2023-02-01 |
publisher | Elsevier |
record_format | Article |
series | Journal of Functional Foods |
spelling | doaj.art-fab2121bf5c240fa99838cc229d29b8a2023-02-05T04:15:40ZengElsevierJournal of Functional Foods1756-46462023-02-01101105432Crocins-rich tomato extracts showed enhanced protective effects in vitroLucía Morote0María Lobato-Gómez1Oussama Ahrazem2Javier Argandoña3Begoña Olmedilla-Alonso4Alberto José López-Jiménez5Gianfranco Diretto6Rossana Cuciniello7Paolo Bergamo8Sarah Frusciante9Enrique Niza10Ángela Rubio-Moraga11Stefania Crispi12Antonio Granell13Lourdes Gómez-Gómez14Instituto Botánico, Departamento de Ciencia y Tecnología Agroforestal y Genética, Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, SpainInstituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas-Universidad Politécnica de València, 46022 Valencia, SpainInstituto Botánico, Departamento de Ciencia y Tecnología Agroforestal y Genética, Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain; Escuela Técnica Superior de Ingeniería Agronómica, y de Montes, y Biotecnología, Departamento de Ciencia y Tecnología Agroforestal y Genética, Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, SpainEscuela Técnica Superior de Ingeniería Agronómica, y de Montes, y Biotecnología, Departamento de Ciencia y Tecnología Agroforestal y Genética, Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, SpainInstitute of Food Science, Technology and Nutrition (ICTAN-CSIC), Department of Metabolism and Nutrition, Spanish National Research Council (CSIC), Madrid, SpainInstituto Botánico, Departamento de Ciencia y Tecnología Agroforestal y Genética, Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain; Escuela Técnica Superior de Ingeniería Agronómica, y de Montes, y Biotecnología, Departamento de Ciencia y Tecnología Agroforestal y Genética, Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, SpainItalian National Agency for New Technologies, Energy, and Sustainable Development, Casaccia Research Centre, 00123 Rome, ItalyInstitute of Biosciences and BioResources-UOS Naples CNR, Via P. Castellino, 111-80131 Naples, Italy; IRCCS Neuromed, 86077 Pozzilli, IS, ItalyInstitute of Biosciences and BioResources-UOS Naples CNR, Via P. Castellino, 111-80131 Naples, ItalyItalian National Agency for New Technologies, Energy, and Sustainable Development, Casaccia Research Centre, 00123 Rome, ItalyInstituto Botánico, Departamento de Ciencia y Tecnología Agroforestal y Genética, Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain; Facultad de Farmacia, Departamento de Ciencia y Tecnología Agroforestal y Genética, Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, SpainInstituto Botánico, Departamento de Ciencia y Tecnología Agroforestal y Genética, Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain; Escuela Técnica Superior de Ingeniería Agronómica, y de Montes, y Biotecnología, Departamento de Ciencia y Tecnología Agroforestal y Genética, Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, SpainInstitute of Biosciences and BioResources-UOS Naples CNR, Via P. Castellino, 111-80131 Naples, ItalyInstituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas-Universidad Politécnica de València, 46022 Valencia, SpainInstituto Botánico, Departamento de Ciencia y Tecnología Agroforestal y Genética, Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain; Facultad de Farmacia, Departamento de Ciencia y Tecnología Agroforestal y Genética, Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain; Corresponding author.Crocins are high-value water soluble pigments that have long been recognized for their medicinal properties, and whose demand has increased worldwide in recent years. In the present study transgenic tomato fruits engineered for the production of crocins and hp3/Bsh tomato mutants with alterations in the carotenoid metabolism, have been combined to increase the levels of crocins in tomato fruits. Tomato fruits from F4 plants showed high antioxidant capacity and the crocin-rich juice of the produced tomato fruit was protected neuroblastoma cells against oxidative insult, through its ability to activate factor 2 related to nuclear erythroid factor 2 (Nrf2). The bio-accessibility of crocins in the juice showed values similar to the ones observed with saffron. Overall, our results support that crocin-fortified tomatoes could result in higher crocin availability and have additional health-promoting effects and could provide better protection against oxidative stress related chronic diseases in humans.http://www.sciencedirect.com/science/article/pii/S1756464623000324ApocarotenoidsCrocinsOxidative-stressSaffronTomato |
spellingShingle | Lucía Morote María Lobato-Gómez Oussama Ahrazem Javier Argandoña Begoña Olmedilla-Alonso Alberto José López-Jiménez Gianfranco Diretto Rossana Cuciniello Paolo Bergamo Sarah Frusciante Enrique Niza Ángela Rubio-Moraga Stefania Crispi Antonio Granell Lourdes Gómez-Gómez Crocins-rich tomato extracts showed enhanced protective effects in vitro Journal of Functional Foods Apocarotenoids Crocins Oxidative-stress Saffron Tomato |
title | Crocins-rich tomato extracts showed enhanced protective effects in vitro |
title_full | Crocins-rich tomato extracts showed enhanced protective effects in vitro |
title_fullStr | Crocins-rich tomato extracts showed enhanced protective effects in vitro |
title_full_unstemmed | Crocins-rich tomato extracts showed enhanced protective effects in vitro |
title_short | Crocins-rich tomato extracts showed enhanced protective effects in vitro |
title_sort | crocins rich tomato extracts showed enhanced protective effects in vitro |
topic | Apocarotenoids Crocins Oxidative-stress Saffron Tomato |
url | http://www.sciencedirect.com/science/article/pii/S1756464623000324 |
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