<i>Polygonum multiflorum</i> Thunb. Hot Water Extract Reverses High-Fat Diet-Induced Lipid Metabolism of White and Brown Adipose Tissues in Obese Mice
The purpose of the present study was to determine whether an anti-obesity effect of a <i>Polygonum multiflorum</i> Thunb. hot water extract (PW) was involved in the lipid metabolism of white adipose tissue (WAT) and brown adipose tissue (BAT) in high-fat diet (HFD)-induced C57BL/6N obese...
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MDPI AG
2021-07-01
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| Online Access: | https://www.mdpi.com/2223-7747/10/8/1509 |
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| author | Ra-Yeong Choi Mi-Kyung Lee |
| author_facet | Ra-Yeong Choi Mi-Kyung Lee |
| author_sort | Ra-Yeong Choi |
| collection | DOAJ |
| description | The purpose of the present study was to determine whether an anti-obesity effect of a <i>Polygonum multiflorum</i> Thunb. hot water extract (PW) was involved in the lipid metabolism of white adipose tissue (WAT) and brown adipose tissue (BAT) in high-fat diet (HFD)-induced C57BL/6N obese mice. Mice freely received a normal diet (NCD) or an HFD for 12 weeks; HFD-fed mice were orally given PW (100 or 300 mg/kg) or garcinia cambogia (GC, 200 mg/kg) once a day. After 12 weeks, PW (300 mg/kg) or GC significantly alleviated adiposity by reducing body weight, WAT weights, and food efficiency ratio. PW (300 mg/kg) improved hyperinsulinemia and enhanced insulin sensitivity. In addition, PW (300 mg/kg) significantly down-regulated expression of carbohydrate-responsive element-binding protein (ChREBP) and diacylglycerol O-acyltransferase 2 (DGAT2) genes in WAT compared with the untreated HFD group. HFD increased BAT gene levels such as adrenoceptor beta 3 (ADRB3), peroxisome proliferator-activated receptor γ (PPARγ), hormone-sensitive lipase (HSL), cluster of differentiation 36 (CD36), fatty acid-binding protein 4 (FABP4), PPARγ coactivator 1-α (PGC-1α), PPARα, and carnitine palmitoyltransferase 1B (CPT1B) compared with the NCD group; however, PW or GC effectively reversed those levels. These findings suggest that the anti-obesity activity of PW was mediated via suppression of lipogenesis in WAT, leading to the normalization of lipid metabolism in BAT. |
| first_indexed | 2024-03-10T08:28:51Z |
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| last_indexed | 2024-03-10T08:28:51Z |
| publishDate | 2021-07-01 |
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| series | Plants |
| spelling | doaj.art-fab2210828504a428b9a6638050f3c1f2023-11-22T09:17:20ZengMDPI AGPlants2223-77472021-07-01108150910.3390/plants10081509<i>Polygonum multiflorum</i> Thunb. Hot Water Extract Reverses High-Fat Diet-Induced Lipid Metabolism of White and Brown Adipose Tissues in Obese MiceRa-Yeong Choi0Mi-Kyung Lee1Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, KoreaDepartment of Food and Nutrition, Sunchon National University, Suncheon 57922, KoreaThe purpose of the present study was to determine whether an anti-obesity effect of a <i>Polygonum multiflorum</i> Thunb. hot water extract (PW) was involved in the lipid metabolism of white adipose tissue (WAT) and brown adipose tissue (BAT) in high-fat diet (HFD)-induced C57BL/6N obese mice. Mice freely received a normal diet (NCD) or an HFD for 12 weeks; HFD-fed mice were orally given PW (100 or 300 mg/kg) or garcinia cambogia (GC, 200 mg/kg) once a day. After 12 weeks, PW (300 mg/kg) or GC significantly alleviated adiposity by reducing body weight, WAT weights, and food efficiency ratio. PW (300 mg/kg) improved hyperinsulinemia and enhanced insulin sensitivity. In addition, PW (300 mg/kg) significantly down-regulated expression of carbohydrate-responsive element-binding protein (ChREBP) and diacylglycerol O-acyltransferase 2 (DGAT2) genes in WAT compared with the untreated HFD group. HFD increased BAT gene levels such as adrenoceptor beta 3 (ADRB3), peroxisome proliferator-activated receptor γ (PPARγ), hormone-sensitive lipase (HSL), cluster of differentiation 36 (CD36), fatty acid-binding protein 4 (FABP4), PPARγ coactivator 1-α (PGC-1α), PPARα, and carnitine palmitoyltransferase 1B (CPT1B) compared with the NCD group; however, PW or GC effectively reversed those levels. These findings suggest that the anti-obesity activity of PW was mediated via suppression of lipogenesis in WAT, leading to the normalization of lipid metabolism in BAT.https://www.mdpi.com/2223-7747/10/8/1509anti-obesityHeshouwu<i>Polygonum multiflorum</i> Thunb.white adipose tissuebrown adipose tissue |
| spellingShingle | Ra-Yeong Choi Mi-Kyung Lee <i>Polygonum multiflorum</i> Thunb. Hot Water Extract Reverses High-Fat Diet-Induced Lipid Metabolism of White and Brown Adipose Tissues in Obese Mice Plants anti-obesity Heshouwu <i>Polygonum multiflorum</i> Thunb. white adipose tissue brown adipose tissue |
| title | <i>Polygonum multiflorum</i> Thunb. Hot Water Extract Reverses High-Fat Diet-Induced Lipid Metabolism of White and Brown Adipose Tissues in Obese Mice |
| title_full | <i>Polygonum multiflorum</i> Thunb. Hot Water Extract Reverses High-Fat Diet-Induced Lipid Metabolism of White and Brown Adipose Tissues in Obese Mice |
| title_fullStr | <i>Polygonum multiflorum</i> Thunb. Hot Water Extract Reverses High-Fat Diet-Induced Lipid Metabolism of White and Brown Adipose Tissues in Obese Mice |
| title_full_unstemmed | <i>Polygonum multiflorum</i> Thunb. Hot Water Extract Reverses High-Fat Diet-Induced Lipid Metabolism of White and Brown Adipose Tissues in Obese Mice |
| title_short | <i>Polygonum multiflorum</i> Thunb. Hot Water Extract Reverses High-Fat Diet-Induced Lipid Metabolism of White and Brown Adipose Tissues in Obese Mice |
| title_sort | i polygonum multiflorum i thunb hot water extract reverses high fat diet induced lipid metabolism of white and brown adipose tissues in obese mice |
| topic | anti-obesity Heshouwu <i>Polygonum multiflorum</i> Thunb. white adipose tissue brown adipose tissue |
| url | https://www.mdpi.com/2223-7747/10/8/1509 |
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