Molecular Basis of Medullary Thyroid Carcinoma: The Role of RET Polymorphisms

Molecular Basis of Medullary Thyroid Carcinoma: The Role of RET Polymorphisms

Medullary thyroid carcinoma is a rare malignant tumor originating in parafollicular C cells. It accounts for 5 to 8% of all thyroid cancers. MTC develops in either sporadic (75%) or hereditary form (25%). Genetic and molecular studies have demonstrated the involvement of the RET proto-oncogene in he...

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Bibliographic Details
Main Authors: Ana Luiza Maia, Carla V. Ferreira, Mírian Romitti, Lucieli Ceolin, Débora R. Siqueira
Format: Article
Language:English
Published: MDPI AG 2011-12-01
Series:International Journal of Molecular Sciences
Subjects:
medullary thyroid carcinoma
RET polymorphisms
prognosis
Online Access:http://www.mdpi.com/1422-0067/13/1/221/

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