Potential role of lncRNA cyp2c91-protein interactions on diseases of the immune system
With unprecedented increase in next generation sequencing (NGS) technologies, there has been a persistent interest on transcript profiles of long noncoding RNAs (lncRNAs) and protein-coding genes forming an interaction network. Apart from protein-protein interaction (PPI), gene network models such a...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-07-01
|
| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00255/full |
| _version_ | 1819151335093698560 |
|---|---|
| author | Prashanth eSuravajhala Lisette J. A. Kogelman Gianluca eMazzoni Haja N Kadarmideen |
| author_facet | Prashanth eSuravajhala Lisette J. A. Kogelman Gianluca eMazzoni Haja N Kadarmideen |
| author_sort | Prashanth eSuravajhala |
| collection | DOAJ |
| description | With unprecedented increase in next generation sequencing (NGS) technologies, there has been a persistent interest on transcript profiles of long noncoding RNAs (lncRNAs) and protein-coding genes forming an interaction network. Apart from protein-protein interaction (PPI), gene network models such as Weighted Gene Co-expression Network Analysis are used to functionally annotate lncRNAs in identifying their potential disease associations. To address this, studies have led to characterizing transcript structures and understanding expression profiles mediating regulatory roles. In the current exploratory analysis, we show how a lncRNA - cyp2c91 contributes to the transcriptional regulation localized to cytoplasm thereby making refractory environment for transcription. By applying network methods and pathway analyses on genes related to a disease such as obesity and systemic lupus erythematosus, we show that we can gain deeper insight in biological processes such as the perturbances in immune system, and get a better understanding of the systems biology of diseases. |
| first_indexed | 2024-12-22T14:31:45Z |
| format | Article |
| id | doaj.art-fab5fe29b04b4300947968a77e11174c |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-22T14:31:45Z |
| publishDate | 2015-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-fab5fe29b04b4300947968a77e11174c2022-12-21T18:22:44ZengFrontiers Media S.A.Frontiers in Genetics1664-80212015-07-01610.3389/fgene.2015.00255146712Potential role of lncRNA cyp2c91-protein interactions on diseases of the immune systemPrashanth eSuravajhala0Lisette J. A. Kogelman1Gianluca eMazzoni2Haja N Kadarmideen3University of CopenhagenUniversity of CopenhagenUniversity of CopenhagenUniversity of CopenhagenWith unprecedented increase in next generation sequencing (NGS) technologies, there has been a persistent interest on transcript profiles of long noncoding RNAs (lncRNAs) and protein-coding genes forming an interaction network. Apart from protein-protein interaction (PPI), gene network models such as Weighted Gene Co-expression Network Analysis are used to functionally annotate lncRNAs in identifying their potential disease associations. To address this, studies have led to characterizing transcript structures and understanding expression profiles mediating regulatory roles. In the current exploratory analysis, we show how a lncRNA - cyp2c91 contributes to the transcriptional regulation localized to cytoplasm thereby making refractory environment for transcription. By applying network methods and pathway analyses on genes related to a disease such as obesity and systemic lupus erythematosus, we show that we can gain deeper insight in biological processes such as the perturbances in immune system, and get a better understanding of the systems biology of diseases.http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00255/fullSystems Biologyprotein interactionsdisease associationlong noncoding RNAWGCNA |
| spellingShingle | Prashanth eSuravajhala Lisette J. A. Kogelman Gianluca eMazzoni Haja N Kadarmideen Potential role of lncRNA cyp2c91-protein interactions on diseases of the immune system Frontiers in Genetics Systems Biology protein interactions disease association long noncoding RNA WGCNA |
| title | Potential role of lncRNA cyp2c91-protein interactions on diseases of the immune system |
| title_full | Potential role of lncRNA cyp2c91-protein interactions on diseases of the immune system |
| title_fullStr | Potential role of lncRNA cyp2c91-protein interactions on diseases of the immune system |
| title_full_unstemmed | Potential role of lncRNA cyp2c91-protein interactions on diseases of the immune system |
| title_short | Potential role of lncRNA cyp2c91-protein interactions on diseases of the immune system |
| title_sort | potential role of lncrna cyp2c91 protein interactions on diseases of the immune system |
| topic | Systems Biology protein interactions disease association long noncoding RNA WGCNA |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00255/full |
| work_keys_str_mv | AT prashanthesuravajhala potentialroleoflncrnacyp2c91proteininteractionsondiseasesoftheimmunesystem AT lisettejakogelman potentialroleoflncrnacyp2c91proteininteractionsondiseasesoftheimmunesystem AT gianlucaemazzoni potentialroleoflncrnacyp2c91proteininteractionsondiseasesoftheimmunesystem AT hajankadarmideen potentialroleoflncrnacyp2c91proteininteractionsondiseasesoftheimmunesystem |