Evidence for Endogenous Opioid Dependence Related to Latent Sensitization in a Rat Model of Chronic Inflammatory Pain

Evidence for Endogenous Opioid Dependence Related to Latent Sensitization in a Rat Model of Chronic Inflammatory Pain

Studies performed in a mouse model of chronic inflammatory pain induced by intraplantar injection of complete Freund’s adjuvant (CFA) have shown that constitutive activation of the endogenous opioid signaling, besides serving as a mechanism of endogenous analgesia that tonically represses pain sensi...

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Bibliographic Details
Main Authors:	Julio César Morales-Medina, Nicola Pugliese, Alessandro Di Cerbo, Claudia Zizzadoro, Tommaso Iannitti
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Series:	International Journal of Molecular Sciences
Subjects:	rodent models complete Freund’s adjuvant peripheral inflammation endogenous opioids species differences nociceptive reinstatement
Online Access:	https://www.mdpi.com/1422-0067/24/3/2812

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