Severity of acute respiratory distress syndrome resulting from tuberculosis correlates with bronchoalveolar lavage CXCL-8 expression

Tuberculosis (TB) has previously been linked to acute respiratory distress syndrome (ARDS). Here this study investigates the link between inflammation and TB in ARDS by measuring inflammatory cytokine and chemokine levels in bronchoalveolar lavage (BAL) from 90 patients with TB or ARDS alone and in...

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Main Authors: I M Adcock, S M.R Hashemian, E Mortaz, M R Masjedi, G Folkerts
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2015-01-01
Series:International Journal of Mycobacteriology
Subjects:
Online Access:http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=5;spage=71;epage=71;aulast=Adcock;type=0
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author I M Adcock
S M.R Hashemian
E Mortaz
M R Masjedi
G Folkerts
author_facet I M Adcock
S M.R Hashemian
E Mortaz
M R Masjedi
G Folkerts
author_sort I M Adcock
collection DOAJ
description Tuberculosis (TB) has previously been linked to acute respiratory distress syndrome (ARDS). Here this study investigates the link between inflammation and TB in ARDS by measuring inflammatory cytokine and chemokine levels in bronchoalveolar lavage (BAL) from 90 patients with TB or ARDS alone and in patients with TB-induced ARDS (ARDS+TB). BAL was collected by fiber-optic bronchoscopy, and the concentrations of interleukin (IL)-6, CXCL8, TNF α and IL-1β were measured by ELISA. CXCL8 levels in BAL were significantly higher in the ARDS+TB group compared with TB and ARDS alone groups. Disease severity in the ARDS+TB group as determined by Murray score correlated with BAL CXCL8 and neutrophils, but not with IL-6, IL-1β and TNF α concentrations. In addition, CXCL8 levels and neutrophils were increased in non-miliary TB versus miliary TB. This difference in CXCL8 was lost in the presence of ARDS. It was concluded from this study that CXCL8 may play an important role in the pathogenesis of this form of ARDS. This further suggests that CXCL8 inhibitors or blockers may be useful to control the onset and/or development of these combined diseases.
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spelling doaj.art-fab830c85c1c4faaa8ea14f84c4191272022-12-22T00:12:57ZengWolters Kluwer Medknow PublicationsInternational Journal of Mycobacteriology2212-55312212-554X2015-01-01457171Severity of acute respiratory distress syndrome resulting from tuberculosis correlates with bronchoalveolar lavage CXCL-8 expressionI M AdcockS M.R HashemianE MortazM R MasjediG FolkertsTuberculosis (TB) has previously been linked to acute respiratory distress syndrome (ARDS). Here this study investigates the link between inflammation and TB in ARDS by measuring inflammatory cytokine and chemokine levels in bronchoalveolar lavage (BAL) from 90 patients with TB or ARDS alone and in patients with TB-induced ARDS (ARDS+TB). BAL was collected by fiber-optic bronchoscopy, and the concentrations of interleukin (IL)-6, CXCL8, TNF α and IL-1β were measured by ELISA. CXCL8 levels in BAL were significantly higher in the ARDS+TB group compared with TB and ARDS alone groups. Disease severity in the ARDS+TB group as determined by Murray score correlated with BAL CXCL8 and neutrophils, but not with IL-6, IL-1β and TNF α concentrations. In addition, CXCL8 levels and neutrophils were increased in non-miliary TB versus miliary TB. This difference in CXCL8 was lost in the presence of ARDS. It was concluded from this study that CXCL8 may play an important role in the pathogenesis of this form of ARDS. This further suggests that CXCL8 inhibitors or blockers may be useful to control the onset and/or development of these combined diseases.http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=5;spage=71;epage=71;aulast=Adcock;type=0TBAcute respiratory distress syndromeInflammationCXCL8
spellingShingle I M Adcock
S M.R Hashemian
E Mortaz
M R Masjedi
G Folkerts
Severity of acute respiratory distress syndrome resulting from tuberculosis correlates with bronchoalveolar lavage CXCL-8 expression
International Journal of Mycobacteriology
TB
Acute respiratory distress syndrome
Inflammation
CXCL8
title Severity of acute respiratory distress syndrome resulting from tuberculosis correlates with bronchoalveolar lavage CXCL-8 expression
title_full Severity of acute respiratory distress syndrome resulting from tuberculosis correlates with bronchoalveolar lavage CXCL-8 expression
title_fullStr Severity of acute respiratory distress syndrome resulting from tuberculosis correlates with bronchoalveolar lavage CXCL-8 expression
title_full_unstemmed Severity of acute respiratory distress syndrome resulting from tuberculosis correlates with bronchoalveolar lavage CXCL-8 expression
title_short Severity of acute respiratory distress syndrome resulting from tuberculosis correlates with bronchoalveolar lavage CXCL-8 expression
title_sort severity of acute respiratory distress syndrome resulting from tuberculosis correlates with bronchoalveolar lavage cxcl 8 expression
topic TB
Acute respiratory distress syndrome
Inflammation
CXCL8
url http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=5;spage=71;epage=71;aulast=Adcock;type=0
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AT emortaz severityofacuterespiratorydistresssyndromeresultingfromtuberculosiscorrelateswithbronchoalveolarlavagecxcl8expression
AT mrmasjedi severityofacuterespiratorydistresssyndromeresultingfromtuberculosiscorrelateswithbronchoalveolarlavagecxcl8expression
AT gfolkerts severityofacuterespiratorydistresssyndromeresultingfromtuberculosiscorrelateswithbronchoalveolarlavagecxcl8expression