Differential Immune Response Following Intranasal and Intradermal Infection with <i>Francisella tularensis:</i> Implications for Vaccine Development
<i>Francisella tularensis</i> (<i>Ft)</i> is a Gram-negative, facultative intracellular coccobacillus that is the etiological agent of tularemia. Interestingly, the disease tularemia has variable clinical presentations that are dependent upon the route of infection with <i...
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MDPI AG
2021-04-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/5/973 |
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| author | McKayla J. Nicol David R. Williamson David E. Place Girish S. Kirimanjeswara |
| author_facet | McKayla J. Nicol David R. Williamson David E. Place Girish S. Kirimanjeswara |
| author_sort | McKayla J. Nicol |
| collection | DOAJ |
| description | <i>Francisella tularensis</i> (<i>Ft)</i> is a Gram-negative, facultative intracellular coccobacillus that is the etiological agent of tularemia. Interestingly, the disease tularemia has variable clinical presentations that are dependent upon the route of infection with <i>Ft</i>. Two of the most likely routes of <i>Ft</i> infection include intranasal and intradermal, which result in pneumonic and ulceroglandular tularemia, respectively. While there are several differences between these two forms of tularemia, the most notable disparity is between mortality rates: the mortality rate following pneumonic tularemia is over ten times that of the ulceroglandular disease. Understanding the differences between intradermal and intranasal <i>Ft</i> infections is important not only for clinical diagnoses and treatment but also for the development of a safe and effective vaccine. However, the immune correlates of protection against <i>Ft</i>, especially within the context of infection by disparate routes, are not yet fully understood. Recent advances in different animal models have revealed new insights in the complex interplay of innate and adaptive immune responses, indicating dissimilar patterns in both responses following infection with <i>Ft</i> via different routes. Further investigation of these differences will be crucial to predicting disease outcomes and inducing protective immunity via vaccination or natural infection. |
| first_indexed | 2024-03-10T11:48:45Z |
| format | Article |
| id | doaj.art-fabaf6de62a14343873545fb11de1836 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T11:48:45Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-fabaf6de62a14343873545fb11de18362023-11-21T17:55:27ZengMDPI AGMicroorganisms2076-26072021-04-019597310.3390/microorganisms9050973Differential Immune Response Following Intranasal and Intradermal Infection with <i>Francisella tularensis:</i> Implications for Vaccine DevelopmentMcKayla J. Nicol0David R. Williamson1David E. Place2Girish S. Kirimanjeswara3Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USADepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USADepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USADepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA<i>Francisella tularensis</i> (<i>Ft)</i> is a Gram-negative, facultative intracellular coccobacillus that is the etiological agent of tularemia. Interestingly, the disease tularemia has variable clinical presentations that are dependent upon the route of infection with <i>Ft</i>. Two of the most likely routes of <i>Ft</i> infection include intranasal and intradermal, which result in pneumonic and ulceroglandular tularemia, respectively. While there are several differences between these two forms of tularemia, the most notable disparity is between mortality rates: the mortality rate following pneumonic tularemia is over ten times that of the ulceroglandular disease. Understanding the differences between intradermal and intranasal <i>Ft</i> infections is important not only for clinical diagnoses and treatment but also for the development of a safe and effective vaccine. However, the immune correlates of protection against <i>Ft</i>, especially within the context of infection by disparate routes, are not yet fully understood. Recent advances in different animal models have revealed new insights in the complex interplay of innate and adaptive immune responses, indicating dissimilar patterns in both responses following infection with <i>Ft</i> via different routes. Further investigation of these differences will be crucial to predicting disease outcomes and inducing protective immunity via vaccination or natural infection.https://www.mdpi.com/2076-2607/9/5/973<i>Francisella tularensis</i>disparate routes of infectionvaccine developmentimmune response |
| spellingShingle | McKayla J. Nicol David R. Williamson David E. Place Girish S. Kirimanjeswara Differential Immune Response Following Intranasal and Intradermal Infection with <i>Francisella tularensis:</i> Implications for Vaccine Development Microorganisms <i>Francisella tularensis</i> disparate routes of infection vaccine development immune response |
| title | Differential Immune Response Following Intranasal and Intradermal Infection with <i>Francisella tularensis:</i> Implications for Vaccine Development |
| title_full | Differential Immune Response Following Intranasal and Intradermal Infection with <i>Francisella tularensis:</i> Implications for Vaccine Development |
| title_fullStr | Differential Immune Response Following Intranasal and Intradermal Infection with <i>Francisella tularensis:</i> Implications for Vaccine Development |
| title_full_unstemmed | Differential Immune Response Following Intranasal and Intradermal Infection with <i>Francisella tularensis:</i> Implications for Vaccine Development |
| title_short | Differential Immune Response Following Intranasal and Intradermal Infection with <i>Francisella tularensis:</i> Implications for Vaccine Development |
| title_sort | differential immune response following intranasal and intradermal infection with i francisella tularensis i implications for vaccine development |
| topic | <i>Francisella tularensis</i> disparate routes of infection vaccine development immune response |
| url | https://www.mdpi.com/2076-2607/9/5/973 |
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