The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells.
<h4>Conclusions</h4>These findings provide further evidence that DLL1 exerts carcinogenic effects in BC cells. The dissimilar effects of DLL1 downregulation observed amongst MCF-7, BT474, and MDA-MB-231 cells is likely due to their distinctive genetic and biologic characteristics, sugges...
Main Authors: | Joana Sales-Dias, Gabriela Silva, Márcia Lamy, Andreia Ferreira, Ana Barbas |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019-01-01
|
Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0217002 |
Similar Items
-
Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo
by: Geffers, I, et al.
Published: (2007) -
Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo.
by: Kristina Preuße, et al.
Published: (2015-06-01) -
The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro
by: Lena Tveriakhina, et al.
Published: (2018-10-01) -
Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine
by: Hiromichi Shimizu, et al.
Published: (2014-05-01) -
Targeting the Notch signaling pathway and the Notch ligand, DLL3, in small cell lung cancer
by: Huan Zhang, et al.
Published: (2023-03-01)