Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases
Recently, second near-infrared (NIR-II) fluorescent imaging has been widely applied in biomedical diagnosis, due to its high spatiotemporal resolution and deep tissue penetration. In contrast to the “always on” NIR-II fluorescent probes, the activatable NIR-II fluorescent probes have specific target...
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| Format: | Article |
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MDPI AG
2021-11-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/11/11/436 |
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| author | Dong Li Jie Pan Shuyu Xu Shiying Fu Chengchao Chu Gang Liu |
| author_facet | Dong Li Jie Pan Shuyu Xu Shiying Fu Chengchao Chu Gang Liu |
| author_sort | Dong Li |
| collection | DOAJ |
| description | Recently, second near-infrared (NIR-II) fluorescent imaging has been widely applied in biomedical diagnosis, due to its high spatiotemporal resolution and deep tissue penetration. In contrast to the “always on” NIR-II fluorescent probes, the activatable NIR-II fluorescent probes have specific targeting to biological tissues, showing a higher imaging signal-to-background ratio and a lower detection limit. Therefore, it is of great significance to utilize disease-associated endogenous stimuli (such as pH values, enzyme existence, hypoxia condition and so on) to activate the NIR-II probes and achieve switchable fluorescent signals for specific deep bioimaging. This review introduces recent strategies and mechanisms for activatable NIR-II fluorescent probes and their applications in biosensing and bioimaging. Moreover, the potential challenges and perspectives of activatable NIR-II fluorescent probes are also discussed. |
| first_indexed | 2024-03-10T05:40:50Z |
| format | Article |
| id | doaj.art-fabde69a6514423eb78079b23046c8a7 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-10T05:40:50Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-fabde69a6514423eb78079b23046c8a72023-11-22T22:36:08ZengMDPI AGBiosensors2079-63742021-11-01111143610.3390/bios11110436Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for DiseasesDong Li0Jie Pan1Shuyu Xu2Shiying Fu3Chengchao Chu4Gang Liu5State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging, Translational Medicine School of Public Health, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging, Translational Medicine School of Public Health, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging, Translational Medicine School of Public Health, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging, Translational Medicine School of Public Health, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging, Translational Medicine School of Public Health, Xiamen University, Xiamen 361102, ChinaState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging, Translational Medicine School of Public Health, Xiamen University, Xiamen 361102, ChinaRecently, second near-infrared (NIR-II) fluorescent imaging has been widely applied in biomedical diagnosis, due to its high spatiotemporal resolution and deep tissue penetration. In contrast to the “always on” NIR-II fluorescent probes, the activatable NIR-II fluorescent probes have specific targeting to biological tissues, showing a higher imaging signal-to-background ratio and a lower detection limit. Therefore, it is of great significance to utilize disease-associated endogenous stimuli (such as pH values, enzyme existence, hypoxia condition and so on) to activate the NIR-II probes and achieve switchable fluorescent signals for specific deep bioimaging. This review introduces recent strategies and mechanisms for activatable NIR-II fluorescent probes and their applications in biosensing and bioimaging. Moreover, the potential challenges and perspectives of activatable NIR-II fluorescent probes are also discussed.https://www.mdpi.com/2079-6374/11/11/436NIR-II fluorescent probesactivatable strategyNIR-II fluorescence imagingbiomarkerbiosensing |
| spellingShingle | Dong Li Jie Pan Shuyu Xu Shiying Fu Chengchao Chu Gang Liu Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases Biosensors NIR-II fluorescent probes activatable strategy NIR-II fluorescence imaging biomarker biosensing |
| title | Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases |
| title_full | Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases |
| title_fullStr | Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases |
| title_full_unstemmed | Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases |
| title_short | Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases |
| title_sort | activatable second near infrared fluorescent probes a new accurate diagnosis strategy for diseases |
| topic | NIR-II fluorescent probes activatable strategy NIR-II fluorescence imaging biomarker biosensing |
| url | https://www.mdpi.com/2079-6374/11/11/436 |
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