Huang-Lian-Jie-Du Decoction Attenuates Atherosclerosis and Increases Plaque Stability in High-Fat Diet-Induced ApoE-/- Mice by Inhibiting M1 Macrophage Polarization and Promoting M2 Macrophage Polarization

Huang-Lian-Jie-Du Decoction Attenuates Atherosclerosis and Increases Plaque Stability in High-Fat Diet-Induced ApoE-/- Mice by Inhibiting M1 Macrophage Polarization and Promoting M2 Macrophage Polarization

Macrophage polarization plays a vital impact in triggering atherosclerosis (AS) progression and regression. Huang-Lian-Jie-Du Decoction (HLJDD), a famous traditional Chinese decoction, displays notable anti-inflammatory and lipid-lowering effects in different animal models. However, its effects and...

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Bibliographic Details
Main Authors: Yinhe Cai, Junmao Wen, Siwen Ma, Zhexing Mai, Qunzhang Zhan, Yijun Wang, Yueyao Zhang, He Chen, Haiyi Li, Wei Wu, Rong Li, Chuanjin Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Physiology
Subjects:
Huang-Lian-Jie-Du decoction
atherosclerosis
plaque stability
macrophages polarization
ApoE−/− mice
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.666449/full

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