Is Melanoma Progression Affected by Thyroid Diseases?
Clinical and epidemiological evidence indicate a relationship between thyroid diseases and melanoma. In particular, the hypothyroidism condition appears to promote melanoma spread, which suggests a protective role of thyroid hormones against disease progression. In addition, experimental data sugges...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/17/10036 |
| _version_ | 1797495041717960704 |
|---|---|
| author | Salvatore Ulisse Enke Baldini Daniele Pironi Federica Gagliardi Domenico Tripodi Augusto Lauro Sabino Carbotta Danilo Tarroni Matteo D’Armiento Aldo Morrone Flavio Forte Flaminia Frattaroli Severino Persechino Teresa Odorisio Vito D’Andrea Eleonora Lori Salvatore Sorrenti |
| author_facet | Salvatore Ulisse Enke Baldini Daniele Pironi Federica Gagliardi Domenico Tripodi Augusto Lauro Sabino Carbotta Danilo Tarroni Matteo D’Armiento Aldo Morrone Flavio Forte Flaminia Frattaroli Severino Persechino Teresa Odorisio Vito D’Andrea Eleonora Lori Salvatore Sorrenti |
| author_sort | Salvatore Ulisse |
| collection | DOAJ |
| description | Clinical and epidemiological evidence indicate a relationship between thyroid diseases and melanoma. In particular, the hypothyroidism condition appears to promote melanoma spread, which suggests a protective role of thyroid hormones against disease progression. In addition, experimental data suggest that, in addition to thyroid hormones, other hormonal players of the hypothalamic–pituitary–thyroid (HPT) axis, namely the thyrotropin releasing hormone and the thyrotropin, are likely to affect melanoma cells behavior. This information warrants further clinical and experimental studies in order to build a precise pattern of action of the HPT hormones on melanoma cells. An improved knowledge of the involved molecular mechanism(s) could lead to a better and possibly personalized clinical management of these patients. |
| first_indexed | 2024-03-10T01:42:51Z |
| format | Article |
| id | doaj.art-fabf38cf0b2447daaa690214833a7151 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:42:51Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fabf38cf0b2447daaa690214833a71512023-11-23T13:21:43ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-0123171003610.3390/ijms231710036Is Melanoma Progression Affected by Thyroid Diseases?Salvatore Ulisse0Enke Baldini1Daniele Pironi2Federica Gagliardi3Domenico Tripodi4Augusto Lauro5Sabino Carbotta6Danilo Tarroni7Matteo D’Armiento8Aldo Morrone9Flavio Forte10Flaminia Frattaroli11Severino Persechino12Teresa Odorisio13Vito D’Andrea14Eleonora Lori15Salvatore Sorrenti16Department of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyScientific Direction, IRCCS San Gallicano Dermatological Institute, 00144 Rome, ItalyScientific Direction, IRCCS San Gallicano Dermatological Institute, 00144 Rome, ItalyUrology Department, M.G. Vannini Hospital, 00177 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Neurosciences, Mental Health and Sensory Organs, “Sapienza” University of Rome, 00161 Rome, ItalyLaboratory of Molecular and Cell Biology, Istituto Dermopatico dell’Immacolata, IDI-IRCCS, 00167 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Surgical Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyClinical and epidemiological evidence indicate a relationship between thyroid diseases and melanoma. In particular, the hypothyroidism condition appears to promote melanoma spread, which suggests a protective role of thyroid hormones against disease progression. In addition, experimental data suggest that, in addition to thyroid hormones, other hormonal players of the hypothalamic–pituitary–thyroid (HPT) axis, namely the thyrotropin releasing hormone and the thyrotropin, are likely to affect melanoma cells behavior. This information warrants further clinical and experimental studies in order to build a precise pattern of action of the HPT hormones on melanoma cells. An improved knowledge of the involved molecular mechanism(s) could lead to a better and possibly personalized clinical management of these patients.https://www.mdpi.com/1422-0067/23/17/10036thyroid diseasescancermelanomapapillary thyroid cancerBRAF mutationsthyroid hormone |
| spellingShingle | Salvatore Ulisse Enke Baldini Daniele Pironi Federica Gagliardi Domenico Tripodi Augusto Lauro Sabino Carbotta Danilo Tarroni Matteo D’Armiento Aldo Morrone Flavio Forte Flaminia Frattaroli Severino Persechino Teresa Odorisio Vito D’Andrea Eleonora Lori Salvatore Sorrenti Is Melanoma Progression Affected by Thyroid Diseases? International Journal of Molecular Sciences thyroid diseases cancer melanoma papillary thyroid cancer BRAF mutations thyroid hormone |
| title | Is Melanoma Progression Affected by Thyroid Diseases? |
| title_full | Is Melanoma Progression Affected by Thyroid Diseases? |
| title_fullStr | Is Melanoma Progression Affected by Thyroid Diseases? |
| title_full_unstemmed | Is Melanoma Progression Affected by Thyroid Diseases? |
| title_short | Is Melanoma Progression Affected by Thyroid Diseases? |
| title_sort | is melanoma progression affected by thyroid diseases |
| topic | thyroid diseases cancer melanoma papillary thyroid cancer BRAF mutations thyroid hormone |
| url | https://www.mdpi.com/1422-0067/23/17/10036 |
| work_keys_str_mv | AT salvatoreulisse ismelanomaprogressionaffectedbythyroiddiseases AT enkebaldini ismelanomaprogressionaffectedbythyroiddiseases AT danielepironi ismelanomaprogressionaffectedbythyroiddiseases AT federicagagliardi ismelanomaprogressionaffectedbythyroiddiseases AT domenicotripodi ismelanomaprogressionaffectedbythyroiddiseases AT augustolauro ismelanomaprogressionaffectedbythyroiddiseases AT sabinocarbotta ismelanomaprogressionaffectedbythyroiddiseases AT danilotarroni ismelanomaprogressionaffectedbythyroiddiseases AT matteodarmiento ismelanomaprogressionaffectedbythyroiddiseases AT aldomorrone ismelanomaprogressionaffectedbythyroiddiseases AT flavioforte ismelanomaprogressionaffectedbythyroiddiseases AT flaminiafrattaroli ismelanomaprogressionaffectedbythyroiddiseases AT severinopersechino ismelanomaprogressionaffectedbythyroiddiseases AT teresaodorisio ismelanomaprogressionaffectedbythyroiddiseases AT vitodandrea ismelanomaprogressionaffectedbythyroiddiseases AT eleonoralori ismelanomaprogressionaffectedbythyroiddiseases AT salvatoresorrenti ismelanomaprogressionaffectedbythyroiddiseases |